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Conference Paper: The effects of gelomyrtol forte® on human ciliary beat frequency in bronchiectasis subjects in vitro

TitleThe effects of gelomyrtol forte® on human ciliary beat frequency in bronchiectasis subjects in vitro
Authors
Issue Date2005
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
The 10th Congress of the APSR & the 1st Congress of the APSR/ACCP, Guangzhou, China, 11-14 November 2005. In Respirology, 2005, v. 10 n. S3, p. A126 Abstract no. 169 How to Cite?
AbstractAim Ciliary beat is the major determinant of mucociliary clearance mechanism, which maintains the sterility of the lower respiratory tract and thereby respiratory health against inhaled pathogens. Gelomyrtol Forte (GF) is phytomedicine, claimed to exhibit seretomucolytic functions and anecodotally used to treat COPD and sinusitis. Our lab have demonstrated that GF causes an increase in ciliary beat frequency (CBF) in healthy subjects in vitro. Its effects have not been studied in bronchiectasis subjects who have a lower basal ciliary beat frequency (CBF) when compared with healthy subjects. Methods We have examined the effects on GF on CBF of human respiratory mucosa of 12 bronchiectasis patients. The mucosa was obtained without anaesthetic from the inferior turbinate and suspended in M199 which contained 0 and 250 ng/mL of GF. Ciliary beat frequency (CBF) for each GF concentration was examined using a phase contrast microscope and a photometric system linked to a digital converter as per standard established protocol in our laboratory at 0.2 and 4 h. Results The following table shows our data. Paired Samples t-test between 0 hr, 2 hr and 4 hr on all groups showed a significant increase in CBF after incubation (0 ng/mL GF and 250 ng/mL, p < 0.001). The increase in CBF was most obvious in the time interval between 0 hr and 2 hour. Also, CBF was significantly higher in samples which were incubated with GF at 250 ng/mL than at 0 ng/mL. (2 hr p = 0.008, 4 hr p = 0.019). Conclusion Our results suggest that Gelomyrtol Forte could have a mucokinetic action in bronchiectasis subjects.
DescriptionPoster presentation
Persistent Identifierhttp://hdl.handle.net/10722/95455
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157

 

DC FieldValueLanguage
dc.contributor.authorKwok, RPen_HK
dc.contributor.authorLeung, YHen_HK
dc.contributor.authorSun, JZen_HK
dc.contributor.authorYan, CPKen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2010-09-25T16:02:48Z-
dc.date.available2010-09-25T16:02:48Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 10th Congress of the APSR & the 1st Congress of the APSR/ACCP, Guangzhou, China, 11-14 November 2005. In Respirology, 2005, v. 10 n. S3, p. A126 Abstract no. 169en_HK
dc.identifier.issn1323-7799en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95455-
dc.descriptionPoster presentation-
dc.description.abstractAim Ciliary beat is the major determinant of mucociliary clearance mechanism, which maintains the sterility of the lower respiratory tract and thereby respiratory health against inhaled pathogens. Gelomyrtol Forte (GF) is phytomedicine, claimed to exhibit seretomucolytic functions and anecodotally used to treat COPD and sinusitis. Our lab have demonstrated that GF causes an increase in ciliary beat frequency (CBF) in healthy subjects in vitro. Its effects have not been studied in bronchiectasis subjects who have a lower basal ciliary beat frequency (CBF) when compared with healthy subjects. Methods We have examined the effects on GF on CBF of human respiratory mucosa of 12 bronchiectasis patients. The mucosa was obtained without anaesthetic from the inferior turbinate and suspended in M199 which contained 0 and 250 ng/mL of GF. Ciliary beat frequency (CBF) for each GF concentration was examined using a phase contrast microscope and a photometric system linked to a digital converter as per standard established protocol in our laboratory at 0.2 and 4 h. Results The following table shows our data. Paired Samples t-test between 0 hr, 2 hr and 4 hr on all groups showed a significant increase in CBF after incubation (0 ng/mL GF and 250 ng/mL, p < 0.001). The increase in CBF was most obvious in the time interval between 0 hr and 2 hour. Also, CBF was significantly higher in samples which were incubated with GF at 250 ng/mL than at 0 ng/mL. (2 hr p = 0.008, 4 hr p = 0.019). Conclusion Our results suggest that Gelomyrtol Forte could have a mucokinetic action in bronchiectasis subjects.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RESen_HK
dc.relation.ispartofRespirologyen_HK
dc.titleThe effects of gelomyrtol forte® on human ciliary beat frequency in bronchiectasis subjects in vitroen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1323-7799&volume=10 &issue=Suppl&spage=A126 (#169)&epage=&date=2005&atitle=The+effects+of+gelomyrtol+forted2+on+human+ciliary+beat+frequency+in+bronchiectasis+subjects+in+vitroen_HK
dc.identifier.emailLeung, YH: yhleung@HKUCC.hku.hken_HK
dc.identifier.emailSun, JZ: jzsun@HKUCC.hku.hken_HK
dc.identifier.emailYan, CPK: cpkyan@HKUSUA.hku.hken_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailLam, WK: lamwk@hku.hken_HK
dc.identifier.emailTsang, KWT: kwttsang@hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1843.2005.00775.x-
dc.identifier.hkuros122108en_HK
dc.identifier.volume10en_HK
dc.identifier.issueSuppl., s3en_HK
dc.identifier.spageA126en_HK
dc.identifier.epageA126-

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