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Conference Paper: Gain of 6p and 20p and loss of 10p and 10q in esophageal squamous cell carcinoma associated with lymph node metastasis

TitleGain of 6p and 20p and loss of 10p and 10q in esophageal squamous cell carcinoma associated with lymph node metastasis
Authors
Issue Date2004
PublisherAmerican Association for Cancer Research
Citation
AACR 95th Annual Meeting, Orlando FL, 27–31 March 2004. In Cancer Research, 2004, v. 64 n. 7S, p. 744 Abstract no. 3214 How to Cite?
AbstractTo understand the genetic mechanisms underlying the progression of esophageal squamous cell carcinoma (ESCC) metastasis, differences of genomic alterations between 15 pairs of primary ESCC tumors and their matched metastatic lymph nodes were analyzed by comparative genomic hybridization (CGH). Chromosomal alterations including loss of 10p, 10q, 17p, 18q, 4p, 13q and gain of 3q, 8q, 6p, 20p, 5p, 18p, 2p, 2q, 1q were detected frequently. The most significant finding was that the gains of chromosome 6p with a minimum high-level amplification region at 6p12-6q12 were found in 7 metastatic lymph nodes but only in 2 corresponding primary tumors (p=0.05) and 20p with a minimum high-level amplification region at 20p12 was found in 11 metastatic lymph nodes but only in 5 corresponding primary tumors (p<0.05). Another interesting finding was the loss of chromosome 10p and 10q which was found in 8 (10p) and 7 (10q) metstatic lymph nodes but only in 2 corresponding primary tumors (p<0.05), respectively. These results suggest that the gains of chromosome 6p and 20p and deletion of chromosome 10 might contribute to the development of ESCC metastasis. The present results provide a candidate amplification region in ESCC for further study to identify oncogenes and tumor suppressor genes related to the development or progression of ESCC. (Supported by Chinese National Outstanding Young Scientists Foundation 30025016 and NCI CA65871; Correspondence to: Dr. Li Dong Wang, Lab. for Cancer Res., College of Medicine, Zhengzhou University, Zhengzhou, Henan, 450052, China. E-mail: lidong0823@sina.com)
Persistent Identifierhttp://hdl.handle.net/10722/95447
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorWang, LDen_HK
dc.contributor.authorQin, Yen_HK
dc.contributor.authorFan, Zen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorHe, Xen_HK
dc.contributor.authorChang, ZWen_HK
dc.contributor.authorLi, JLen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorTsao, GSWen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorZheng, Sen_HK
dc.contributor.authorYang, CSen_HK
dc.contributor.authorLi, Jen_HK
dc.date.accessioned2010-09-25T16:02:33Z-
dc.date.available2010-09-25T16:02:33Z-
dc.date.issued2004en_HK
dc.identifier.citationAACR 95th Annual Meeting, Orlando FL, 27–31 March 2004. In Cancer Research, 2004, v. 64 n. 7S, p. 744 Abstract no. 3214en_HK
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/95447-
dc.description.abstractTo understand the genetic mechanisms underlying the progression of esophageal squamous cell carcinoma (ESCC) metastasis, differences of genomic alterations between 15 pairs of primary ESCC tumors and their matched metastatic lymph nodes were analyzed by comparative genomic hybridization (CGH). Chromosomal alterations including loss of 10p, 10q, 17p, 18q, 4p, 13q and gain of 3q, 8q, 6p, 20p, 5p, 18p, 2p, 2q, 1q were detected frequently. The most significant finding was that the gains of chromosome 6p with a minimum high-level amplification region at 6p12-6q12 were found in 7 metastatic lymph nodes but only in 2 corresponding primary tumors (p=0.05) and 20p with a minimum high-level amplification region at 20p12 was found in 11 metastatic lymph nodes but only in 5 corresponding primary tumors (p<0.05). Another interesting finding was the loss of chromosome 10p and 10q which was found in 8 (10p) and 7 (10q) metstatic lymph nodes but only in 2 corresponding primary tumors (p<0.05), respectively. These results suggest that the gains of chromosome 6p and 20p and deletion of chromosome 10 might contribute to the development of ESCC metastasis. The present results provide a candidate amplification region in ESCC for further study to identify oncogenes and tumor suppressor genes related to the development or progression of ESCC. (Supported by Chinese National Outstanding Young Scientists Foundation 30025016 and NCI CA65871; Correspondence to: Dr. Li Dong Wang, Lab. for Cancer Res., College of Medicine, Zhengzhou University, Zhengzhou, Henan, 450052, China. E-mail: lidong0823@sina.com)-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleGain of 6p and 20p and loss of 10p and 10q in esophageal squamous cell carcinoma associated with lymph node metastasisen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailQin, Y: yanruqin@sohu.comen_HK
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_HK
dc.identifier.emailGuan, XY: xyguan@hkucc.hku.hken_HK
dc.identifier.emailTsao, GSW: gswtsao@hkucc.hku.hken_HK
dc.identifier.emailSham, JST: jstsham@hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityTsao, GSW=rp00399en_HK
dc.identifier.hkuros95691en_HK
dc.identifier.volume64en_HK
dc.identifier.spage744en_HK

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