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Conference Paper: The effects of myrtol standardized on human ciliary beat frequency in vitro

TitleThe effects of myrtol standardized on human ciliary beat frequency in vitro
Authors
Issue Date2005
PublisherEuropean Respiratory Society
Citation
E-Learning Resources Annual Congress, Copenhagen, 17-21 September 2005. In European Respiratory Journal, 2005, v. 26 n. Suppl 49, p. 100S Abstract no. 714 How to Cite?
AbstractPurpose: Ciliary beat is a key determinant of mucociliary clearance meachanism, which maintains the respiratory health against inhaled pathogens and accumulating debris in the airways. Myrtol standardized, the active ingredient of Gelomyrtol Forte (GF), which is a phytomedicine claimed to exhibit seretomucolytic functions and anecdotally used to as treatment for COPD and sinusitis. Nonetheless, the effects of GF on ciliary beat have not been studied in a systematic manner. Methods: We have examined the effects of GF on the ciliary beat frequency (CBF) of human respiratory mucosa. The latter was obtained without anaesthetics from the inferior turbinate of 33 healthy subjects, and suspended in M199 which contained 0 and 250 ng/ml of GF.CBF for each GF concentration was examined using a phase contrast microscope and a photometric system linked to a digital converter as per standard established protocol in our laboratory at 0, 4 and 24 h. Results: Paired-sample t-test between 0hr and 4hr on all groups showed significant increase in CBF after incubation (0ng/ml GF, p=0.002 and 250ng/ml, p<0.001). There was a trend towards higher CBF after GF incubation at 4 hr. Also, CBF was significantly higher in samples which incubated with GF 250ng/ml than 0ng/ml (p<0.001). Conclusion: Our results suggest that GF could have a mucokinetic action.
Persistent Identifierhttp://hdl.handle.net/10722/95362
ISSN
2006 SCImago Journal Rankings: 1.522

 

DC FieldValueLanguage
dc.contributor.authorKwok, RPen_HK
dc.contributor.authorLeung, YHen_HK
dc.contributor.authorSun, JZen_HK
dc.contributor.authorYan, CPKen_HK
dc.contributor.authorKo, KWen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2010-09-25T15:59:48Z-
dc.date.available2010-09-25T15:59:48Z-
dc.date.issued2005en_HK
dc.identifier.citationE-Learning Resources Annual Congress, Copenhagen, 17-21 September 2005. In European Respiratory Journal, 2005, v. 26 n. Suppl 49, p. 100S Abstract no. 714en_HK
dc.identifier.issn0904-1850-
dc.identifier.urihttp://hdl.handle.net/10722/95362-
dc.description.abstractPurpose: Ciliary beat is a key determinant of mucociliary clearance meachanism, which maintains the respiratory health against inhaled pathogens and accumulating debris in the airways. Myrtol standardized, the active ingredient of Gelomyrtol Forte (GF), which is a phytomedicine claimed to exhibit seretomucolytic functions and anecdotally used to as treatment for COPD and sinusitis. Nonetheless, the effects of GF on ciliary beat have not been studied in a systematic manner. Methods: We have examined the effects of GF on the ciliary beat frequency (CBF) of human respiratory mucosa. The latter was obtained without anaesthetics from the inferior turbinate of 33 healthy subjects, and suspended in M199 which contained 0 and 250 ng/ml of GF.CBF for each GF concentration was examined using a phase contrast microscope and a photometric system linked to a digital converter as per standard established protocol in our laboratory at 0, 4 and 24 h. Results: Paired-sample t-test between 0hr and 4hr on all groups showed significant increase in CBF after incubation (0ng/ml GF, p=0.002 and 250ng/ml, p<0.001). There was a trend towards higher CBF after GF incubation at 4 hr. Also, CBF was significantly higher in samples which incubated with GF 250ng/ml than 0ng/ml (p<0.001). Conclusion: Our results suggest that GF could have a mucokinetic action.-
dc.languageengen_HK
dc.publisherEuropean Respiratory Society-
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.titleThe effects of myrtol standardized on human ciliary beat frequency in vitroen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLeung, YH: yhleung@HKUCC.hku.hken_HK
dc.identifier.emailSun, JZ: jzsun@HKUCC.hku.hken_HK
dc.identifier.emailYan, CPK: cpkyan@HKUSUA.hku.hken_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailLam, WK: lamwk@hku.hken_HK
dc.identifier.emailTsang, KWT: kwttsang@hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.identifier.hkuros122097en_HK
dc.identifier.volume26en_HK
dc.identifier.issueSuppl 49en_HK
dc.identifier.spage100en_HK
dc.publisher.placeSwitzerland-

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