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Conference Paper: Abnormalies of scotopic electroretinography in rats with laser-induced ocular hypertension

TitleAbnormalies of scotopic electroretinography in rats with laser-induced ocular hypertension
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 125 How to Cite?
AbstractScotopic threshold response (STR) and negative response (NR) in flash electroretinography (ERG) have been found to be related to the response from inner retina. These are useful indicators to assess the functional changes in inner retina of animal ocular hypertension models which always involve the damage of retinal ganglion cells (RGCs). In the present study, ERG was used to investigate the functional changes of retina in a laser-induced ocular hypertension model. Ocular hypertension was induced unilaterally using Argon laser photocoagulation of the episcleral veins and limbal veins in Sprague-Dawley adult rats. Intraocular pressure (IOP) was measured with a calibrated tonopen. For studying the number of RGC loss at different time-points, the RGCs were labeled with FluoroGold four days before sacrifice of the animals. ERG was measured in these animals before the laser treatment, at two weeks, four weeks and eight weeks after the laser treatment. The animals were under general anesthesia during all the experimental procedures. There was about 1.6-fold increase of intraocular pressure (IOP) in the experimental eyes after the laser photocoagulation compared to those of the control eyes and the elevated IOP could be maintained at a quite steady level for at least eight weeks. The amplitudes of STR and NR were markedly attenuated together with the progressive loss of RGCs after the induction of ocular hypertension. This indicates that the elevation of IOP in this ocular hypertension model causes functional impairments in inner retina and this result is beneficial to future glaucoma studies using this model. Acknowledgement: This study was supported by the award from The University of Hong Kong, the donation from the late Mr. And Mrs. Ma Yip Seng, the research grant from the Research Grant Committee of the Hong Kong Special Administrative Region and the research grant (G-T506) from The Hong Kong Polytechnic University.
Persistent Identifierhttp://hdl.handle.net/10722/95307
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorLi, SYen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorChan, HHen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-25T15:58:05Z-
dc.date.available2010-09-25T15:58:05Z-
dc.date.issued2006en_HK
dc.identifier.citationThe Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 125en_HK
dc.identifier.issn1424-862X-
dc.identifier.urihttp://hdl.handle.net/10722/95307-
dc.description.abstractScotopic threshold response (STR) and negative response (NR) in flash electroretinography (ERG) have been found to be related to the response from inner retina. These are useful indicators to assess the functional changes in inner retina of animal ocular hypertension models which always involve the damage of retinal ganglion cells (RGCs). In the present study, ERG was used to investigate the functional changes of retina in a laser-induced ocular hypertension model. Ocular hypertension was induced unilaterally using Argon laser photocoagulation of the episcleral veins and limbal veins in Sprague-Dawley adult rats. Intraocular pressure (IOP) was measured with a calibrated tonopen. For studying the number of RGC loss at different time-points, the RGCs were labeled with FluoroGold four days before sacrifice of the animals. ERG was measured in these animals before the laser treatment, at two weeks, four weeks and eight weeks after the laser treatment. The animals were under general anesthesia during all the experimental procedures. There was about 1.6-fold increase of intraocular pressure (IOP) in the experimental eyes after the laser photocoagulation compared to those of the control eyes and the elevated IOP could be maintained at a quite steady level for at least eight weeks. The amplitudes of STR and NR were markedly attenuated together with the progressive loss of RGCs after the induction of ocular hypertension. This indicates that the elevation of IOP in this ocular hypertension model causes functional impairments in inner retina and this result is beneficial to future glaucoma studies using this model. Acknowledgement: This study was supported by the award from The University of Hong Kong, the donation from the late Mr. And Mrs. Ma Yip Seng, the research grant from the Research Grant Committee of the Hong Kong Special Administrative Region and the research grant (G-T506) from The Hong Kong Polytechnic University.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG-
dc.relation.ispartofNeurosignalsen_HK
dc.titleAbnormalies of scotopic electroretinography in rats with laser-induced ocular hypertensionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros107939en_HK
dc.identifier.spage49en_HK
dc.identifier.epage49en_HK

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