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Conference Paper: The modulation of paroxetine to the suppressive effect of corticosteroid on adult hippocampal neurogenesis

TitleThe modulation of paroxetine to the suppressive effect of corticosteroid on adult hippocampal neurogenesis
Authors
KeywordsSTRESS
DEPRESSION
NEUROPROTECTION
SSRI
Issue Date2005
PublisherSociety for Neuroscience
Citation
Neuroscience 2005, Washington, DC, 12-16 November 2005, Presentation no. 552.3 How to Cite?
AbstractBackground: Clinical experience and previous research showed that cognitive deficiency or emotional changes might occur with chronic treatment of glucocorticoids. Results from animal studies, suggested that this might be caused by the suppressive effect of glucocorticoid on hippocampal neurogenesis. Paroxetine is a specific and potent serotonin uptake inhibitor antidepressant (SSRI) commonly used in psychiatry. Here, we investigated whether the long term use of Paroxetine 1) increases adult hippocampal neurogenesis and 2) reverses the reduced neurogenesis induced by corticosteroid. Methods: Adult male SD rats were given daily injection of vehicle, corticosteroid, Paroxetine, or both corticosteroid and Paroxetine for 14 days. Cell proliferation in the dentate gyrus was quantified by using BrdU immunohistochemistry, and the number of BrdU positive cells was evaluated. Results: Our results showed that corticosteroids suppressed hippocampal neurogenesis. Chronic Paroxetine treatment alone resulted in the increase of adult hippocampal neurogenesis. More importantly, this treatment could reverse the suppressive effect of corticosteroid on hippocampal neurogenesis. Conclusion: These data demonstrate that chronic treatment with paroxetine can protect the hippocampus from the potentially deleterious effects of corticosteroid on neurogenesis which provides a clue to prevent hippocampal damage during the chronic use of glucocorticoids in the clinic. Corresponding authors: KF So and SW Tang.
DescriptionProgram no. 552.3
Persistent Identifierhttp://hdl.handle.net/10722/95273

 

DC FieldValueLanguage
dc.contributor.authorQiu, Gen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorHelmeste, DMen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-25T15:57:02Z-
dc.date.available2010-09-25T15:57:02Z-
dc.date.issued2005en_HK
dc.identifier.citationNeuroscience 2005, Washington, DC, 12-16 November 2005, Presentation no. 552.3en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95273-
dc.descriptionProgram no. 552.3-
dc.description.abstractBackground: Clinical experience and previous research showed that cognitive deficiency or emotional changes might occur with chronic treatment of glucocorticoids. Results from animal studies, suggested that this might be caused by the suppressive effect of glucocorticoid on hippocampal neurogenesis. Paroxetine is a specific and potent serotonin uptake inhibitor antidepressant (SSRI) commonly used in psychiatry. Here, we investigated whether the long term use of Paroxetine 1) increases adult hippocampal neurogenesis and 2) reverses the reduced neurogenesis induced by corticosteroid. Methods: Adult male SD rats were given daily injection of vehicle, corticosteroid, Paroxetine, or both corticosteroid and Paroxetine for 14 days. Cell proliferation in the dentate gyrus was quantified by using BrdU immunohistochemistry, and the number of BrdU positive cells was evaluated. Results: Our results showed that corticosteroids suppressed hippocampal neurogenesis. Chronic Paroxetine treatment alone resulted in the increase of adult hippocampal neurogenesis. More importantly, this treatment could reverse the suppressive effect of corticosteroid on hippocampal neurogenesis. Conclusion: These data demonstrate that chronic treatment with paroxetine can protect the hippocampus from the potentially deleterious effects of corticosteroid on neurogenesis which provides a clue to prevent hippocampal damage during the chronic use of glucocorticoids in the clinic. Corresponding authors: KF So and SW Tang.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectSTRESS-
dc.subjectDEPRESSION-
dc.subjectNEUROPROTECTION-
dc.subjectSSRI-
dc.titleThe modulation of paroxetine to the suppressive effect of corticosteroid on adult hippocampal neurogenesisen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLee, TMC: tmclee@hkusua.hku.hken_HK
dc.identifier.emailTang, SW: mswtang@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros112456en_HK

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