File Download

There are no files associated with this item.

Supplementary

Conference Paper: Long-term effect of ventral root re-implantation on motoneuron survival following spinal root avulsion in adult rat

TitleLong-term effect of ventral root re-implantation on motoneuron survival following spinal root avulsion in adult rat
Authors
Issue Date2001
PublisherSociety for Neuroscience
Citation
Neuroscience 2001, San Diego, CA, 10-15 November 2001, Presentation no. 829.9 How to Cite?
AbstractWe have previously reported that re-implantation of ventral root can enhance motoneuron (MN) survival up to 6 weeks after root avulsion and surviving motoneurons can regenerate their axons into the re-implanted root. The aim of the present study is to investigate the long-term survival effect of root re-implantation. Axonal regeneration and myelination are also studied. Following root avulsion and re-implantation, animals in all groups were allowed to survival for 3, 6 or 12 months. Regenerating MNs were retrogradely labeled by fluorescent dye. In root re-implanted animals, about 60-70% of injured motoneurons survived up to 12 months after injury, while only 20% survival were found in the control animals. About 80% of the surviving motoneurons were found to regenerate their axons into the re-implanted ventral root. By 3 weeks after avulsion, myelin degeneration was widely spread throughout the lesioned ventral roots. In re-implantation groups, at 3 and 6 weeks after treatment, scattered Schwann cell myelinated axons within the demyelinated regions were observed. At 6 and 12 months after treatment, numerous thinly oligodendrocyte-myelinated axons were mixed with Schwann cell myelinated axons. Compared with the normal axons, newly formed myelinated axons were irregular in shape and orientation. Results of the present study show that re-implantation of avulsed ventral root can greatly enhance long-term motoneuron survival and these surviving motoneurons can regrow their axons into the original ventral root and get remyelinated. Supported by RGC grants, Hong Kong
Persistent Identifierhttp://hdl.handle.net/10722/95260

 

DC FieldValueLanguage
dc.contributor.authorChai, Hen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKFen_HK
dc.date.accessioned2010-09-25T15:56:38Z-
dc.date.available2010-09-25T15:56:38Z-
dc.date.issued2001en_HK
dc.identifier.citationNeuroscience 2001, San Diego, CA, 10-15 November 2001, Presentation no. 829.9-
dc.identifier.urihttp://hdl.handle.net/10722/95260-
dc.description.abstractWe have previously reported that re-implantation of ventral root can enhance motoneuron (MN) survival up to 6 weeks after root avulsion and surviving motoneurons can regenerate their axons into the re-implanted root. The aim of the present study is to investigate the long-term survival effect of root re-implantation. Axonal regeneration and myelination are also studied. Following root avulsion and re-implantation, animals in all groups were allowed to survival for 3, 6 or 12 months. Regenerating MNs were retrogradely labeled by fluorescent dye. In root re-implanted animals, about 60-70% of injured motoneurons survived up to 12 months after injury, while only 20% survival were found in the control animals. About 80% of the surviving motoneurons were found to regenerate their axons into the re-implanted ventral root. By 3 weeks after avulsion, myelin degeneration was widely spread throughout the lesioned ventral roots. In re-implantation groups, at 3 and 6 weeks after treatment, scattered Schwann cell myelinated axons within the demyelinated regions were observed. At 6 and 12 months after treatment, numerous thinly oligodendrocyte-myelinated axons were mixed with Schwann cell myelinated axons. Compared with the normal axons, newly formed myelinated axons were irregular in shape and orientation. Results of the present study show that re-implantation of avulsed ventral root can greatly enhance long-term motoneuron survival and these surviving motoneurons can regrow their axons into the original ventral root and get remyelinated. Supported by RGC grants, Hong Kong-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleLong-term effect of ventral root re-implantation on motoneuron survival following spinal root avulsion in adult raten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HKF: hkfyip@hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros109270en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats