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Conference Paper: Significance of neuroprotective polysaccharide from the flowers of Nerium indicum in beta-amyloid peptides neurotoxicity

TitleSignificance of neuroprotective polysaccharide from the flowers of Nerium indicum in beta-amyloid peptides neurotoxicity
Authors
Issue Date2006
PublisherSociety for Neuroscience
Citation
Neuroscience 2006, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 826.9/CC27 How to Cite?
AbstractPolysaccharides purified from Chinese medicinal herbs have been investigated extensively for their biological activities and therapeutic effects. Most of them showed anti-tumor and immune stimulating effects. However, little is known about their effects on neurons. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (Aβ) peptides. In this study, we have characterized a fraction of new polysaccharide from N. indicum (named as J6) and aim to investigate whether it can protect cortical neurons against Aβ-induced apoptosis. Primary cortical neurons prepared from embryonic day 17 SD rats were employed. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by Aβ peptides. Western blot analysis indicated that J6 could markedly inhibit the Aβ peptide-stimulated phosphorylation of JNK-1. Taken together, the polysaccharide J6 extracted from the flowers of N. indicum can serve as potential neuroprotective agent against neuronal death in Alzheimer’s disease and the neuroprotective mechanism may primarily rely on inactivation of JNK signaling pathway.
Persistent Identifierhttp://hdl.handle.net/10722/95223

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T15:55:29Z-
dc.date.available2010-09-25T15:55:29Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuroscience 2006, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 826.9/CC27en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95223-
dc.description.abstractPolysaccharides purified from Chinese medicinal herbs have been investigated extensively for their biological activities and therapeutic effects. Most of them showed anti-tumor and immune stimulating effects. However, little is known about their effects on neurons. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (Aβ) peptides. In this study, we have characterized a fraction of new polysaccharide from N. indicum (named as J6) and aim to investigate whether it can protect cortical neurons against Aβ-induced apoptosis. Primary cortical neurons prepared from embryonic day 17 SD rats were employed. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by Aβ peptides. Western blot analysis indicated that J6 could markedly inhibit the Aβ peptide-stimulated phosphorylation of JNK-1. Taken together, the polysaccharide J6 extracted from the flowers of N. indicum can serve as potential neuroprotective agent against neuronal death in Alzheimer’s disease and the neuroprotective mechanism may primarily rely on inactivation of JNK signaling pathway.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleSignificance of neuroprotective polysaccharide from the flowers of Nerium indicum in beta-amyloid peptides neurotoxicityen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYuen, WH: whyuen@srpdfond.comen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.hkuros124889en_HK

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