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Conference Paper: LINGO-1 Exerts neuroprotection in a rat glaucoma model

TitleLINGO-1 Exerts neuroprotection in a rat glaucoma model
Authors
Issue Date2005
PublisherAssociation for Research in Vision and Ophthalmology
Citation
The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, 1-4 May 2005. In Investigative Ophthalmology & Visual Science, 2005, v. 46 n. 13, p. 157 How to Cite?
AbstractAbstract: : Purpose: Axon regeneration in the central nervous system (CNS) is hindered by the presence of myelin inhibitory molecules. LINGO–1 is a new member of the myelin receptor complex besides NogoR1 and p75. This study was conducted to investigate the effect of LINGO–1 Fc fusion protein in the survival of retinal ganglion cells (RGCs) in a rat glaucoma model. Methods:Experimental glaucoma was induced in the right eye of each animal by elevating the intraocular pressure (IOP), and the left eye was used as control. Laser photocoagulation was applied twice to the episcleral and limbal veins at 7days interval. LINGO–1 Fc fusion protein was injected into the vitreous of the right eye after the first laser application. The loss of RGCs labeled by Fluoro–Gold was determined from flat–mounted retina 14 days later. Results:There was a significant loss of RGCs (13.2%) following the induction of elevated IOP in the PBS injection group. There was also a 10.6% RGCs loss in the human IgG injection group. A single intravitreal injection of LINGO–1 Fc fusion protein showed significant neuroprotective effect in enhancing the survival of RGCs (RGC death of –0.3%). Conclusions: These results provide evidence that LINGO–1 Fc fusion protein exerts neuroprotective activity to damaged RGCs in hypertensive eyes. It suggests that modulation of the interaction of myelin inhibitory proteins with their receptors has therapeutic application for CNS injury.
Persistent Identifierhttp://hdl.handle.net/10722/95221
ISSN

 

DC FieldValueLanguage
dc.contributor.authorFu, Qen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorMi, Sen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-25T15:55:26Z-
dc.date.available2010-09-25T15:55:26Z-
dc.date.issued2005en_HK
dc.identifier.citationThe Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, 1-4 May 2005. In Investigative Ophthalmology & Visual Science, 2005, v. 46 n. 13, p. 157en_HK
dc.identifier.issn1552-5783-
dc.identifier.urihttp://hdl.handle.net/10722/95221-
dc.description.abstractAbstract: : Purpose: Axon regeneration in the central nervous system (CNS) is hindered by the presence of myelin inhibitory molecules. LINGO–1 is a new member of the myelin receptor complex besides NogoR1 and p75. This study was conducted to investigate the effect of LINGO–1 Fc fusion protein in the survival of retinal ganglion cells (RGCs) in a rat glaucoma model. Methods:Experimental glaucoma was induced in the right eye of each animal by elevating the intraocular pressure (IOP), and the left eye was used as control. Laser photocoagulation was applied twice to the episcleral and limbal veins at 7days interval. LINGO–1 Fc fusion protein was injected into the vitreous of the right eye after the first laser application. The loss of RGCs labeled by Fluoro–Gold was determined from flat–mounted retina 14 days later. Results:There was a significant loss of RGCs (13.2%) following the induction of elevated IOP in the PBS injection group. There was also a 10.6% RGCs loss in the human IgG injection group. A single intravitreal injection of LINGO–1 Fc fusion protein showed significant neuroprotective effect in enhancing the survival of RGCs (RGC death of –0.3%). Conclusions: These results provide evidence that LINGO–1 Fc fusion protein exerts neuroprotective activity to damaged RGCs in hypertensive eyes. It suggests that modulation of the interaction of myelin inhibitory proteins with their receptors has therapeutic application for CNS injury.-
dc.languageengen_HK
dc.publisherAssociation for Research in Vision and Ophthalmology-
dc.relation.ispartofInvestigative Ophthalmology & Visual Scienceen_HK
dc.titleLINGO-1 Exerts neuroprotection in a rat glaucoma modelen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros107500en_HK
dc.identifier.spage7en_HK
dc.identifier.epage131en_HK

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