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Conference Paper: Caspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats

TitleCaspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats
Authors
KeywordsApoptosis
Axotomy
Death
Dose-response
Issue Date2000
PublisherSociety for Neuroscience
Citation
The 30th Annual Meeting of Society for Neuroscience (Neuroscience 2000), New Orleans, LA., 4-9 November 2000. How to Cite?
AbstractThe loss of motoneurons following injury (axotomy/avulsion) in neonatal mammals occurs by an apoptotic-like pathway of morphological degeneration. Caspases are important mediators of apoptosis. The present study investigated the effects of the caspase inhibitors, benzyloxycarbonyl-Asp(Ome) fluoromethylketone (Boc-D-FMK), and N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO), on the survival of neonatal spinal motoneurons after root avulsion of C7 spinal cord. In control animals, virtually all motoneurons died 7 days after root avulsion. Treatment with either 0.5μg Boc-D-FMK or 1μg Ac-DEVD-CHO enhanced the survival of motoneurons by 80% and 85% of controls, respectively, for up to 7 days post-injury. Lower concentrations resulted in less motoneuron survival. Caspase inhibitors rescue postnatal mammalian motoneurons from injury-induced (avulsion) cell death consistent with the apoptotic nature of their degeneration. (Supported by research grants from the University of Hong Kong and Hong Kong Research Grant Council).
DescriptionPresentation no. 122.1
Persistent Identifierhttp://hdl.handle.net/10722/95124

 

DC FieldValueLanguage
dc.contributor.authorChan, YMen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorYip, HKFen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorOppenheim, RWen_HK
dc.date.accessioned2010-09-25T15:52:24Z-
dc.date.available2010-09-25T15:52:24Z-
dc.date.issued2000en_HK
dc.identifier.citationThe 30th Annual Meeting of Society for Neuroscience (Neuroscience 2000), New Orleans, LA., 4-9 November 2000.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95124-
dc.descriptionPresentation no. 122.1-
dc.description.abstractThe loss of motoneurons following injury (axotomy/avulsion) in neonatal mammals occurs by an apoptotic-like pathway of morphological degeneration. Caspases are important mediators of apoptosis. The present study investigated the effects of the caspase inhibitors, benzyloxycarbonyl-Asp(Ome) fluoromethylketone (Boc-D-FMK), and N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO), on the survival of neonatal spinal motoneurons after root avulsion of C7 spinal cord. In control animals, virtually all motoneurons died 7 days after root avulsion. Treatment with either 0.5μg Boc-D-FMK or 1μg Ac-DEVD-CHO enhanced the survival of motoneurons by 80% and 85% of controls, respectively, for up to 7 days post-injury. Lower concentrations resulted in less motoneuron survival. Caspase inhibitors rescue postnatal mammalian motoneurons from injury-induced (avulsion) cell death consistent with the apoptotic nature of their degeneration. (Supported by research grants from the University of Hong Kong and Hong Kong Research Grant Council).-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofNeuroscience 2000en_HK
dc.subjectApoptosis-
dc.subjectAxotomy-
dc.subjectDeath-
dc.subjectDose-response-
dc.titleCaspase inhibitors rescue spinal motoneurons after root avulsion in neonatal ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailYip, HKF: hkfyip@hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros56125en_HK

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