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Conference Paper: Caspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats

TitleCaspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats
Authors
KeywordsAPOPTOSIS
AXOTOMY
DEATH
DOSE-RESPONSE
Issue Date2000
PublisherSociety for Neuroscience
Citation
Neuroscience 2000, New Orleans, LA, 4-9 November 2000, Presentation no. 122.1 How to Cite?
AbstractThe loss of motoneurons following injury (axotomy/avulsion) in neonatal mammals occurs by an apoptotic-like pathway of morphological degeneration. Caspases are important mediators of apoptosis. The present study investigated the effects of the caspase inhibitors, benzyloxycarbonyl-Asp(Ome) fluoromethylketone (Boc-D-FMK), and N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO), on the survival of neonatal spinal motoneurons after root avulsion of C7 spinal cord. In control animals, virtually all motoneurons died 7 days after root avulsion. Treatment with either 0.5μg Boc-D-FMK or 1μg Ac-DEVD-CHO enhanced the survival of motoneurons by 80% and 85% of controls, respectively, for up to 7 days post-injury. Lower concentrations resulted in less motoneuron survival. Caspase inhibitors rescue postnatal mammalian motoneurons from injury-induced (avulsion) cell death consistent with the apoptotic nature of their degeneration. (Supported by research grants from the University of Hong Kong and Hong Kong Research Grant Council).
Persistent Identifierhttp://hdl.handle.net/10722/95124

 

DC FieldValueLanguage
dc.contributor.authorChan, YMen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorYip, HKFen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorOppenheim, RWen_HK
dc.date.accessioned2010-09-25T15:52:24Z-
dc.date.available2010-09-25T15:52:24Z-
dc.date.issued2000en_HK
dc.identifier.citationNeuroscience 2000, New Orleans, LA, 4-9 November 2000, Presentation no. 122.1en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95124-
dc.description.abstractThe loss of motoneurons following injury (axotomy/avulsion) in neonatal mammals occurs by an apoptotic-like pathway of morphological degeneration. Caspases are important mediators of apoptosis. The present study investigated the effects of the caspase inhibitors, benzyloxycarbonyl-Asp(Ome) fluoromethylketone (Boc-D-FMK), and N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO), on the survival of neonatal spinal motoneurons after root avulsion of C7 spinal cord. In control animals, virtually all motoneurons died 7 days after root avulsion. Treatment with either 0.5μg Boc-D-FMK or 1μg Ac-DEVD-CHO enhanced the survival of motoneurons by 80% and 85% of controls, respectively, for up to 7 days post-injury. Lower concentrations resulted in less motoneuron survival. Caspase inhibitors rescue postnatal mammalian motoneurons from injury-induced (avulsion) cell death consistent with the apoptotic nature of their degeneration. (Supported by research grants from the University of Hong Kong and Hong Kong Research Grant Council).-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectAPOPTOSIS-
dc.subjectAXOTOMY-
dc.subjectDEATH-
dc.subjectDOSE-RESPONSE-
dc.titleCaspase inhibitors rescue spinal motoneurons after root avulsion in neonatal ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailYip, HKF: hkfyip@hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros56125en_HK

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