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Conference Paper: Derivatives of garlic inhibit prostate cancer cell growth under in vitro and in vivo conditions

TitleDerivatives of garlic inhibit prostate cancer cell growth under in vitro and in vivo conditions
Authors
Issue Date2007
PublisherJapanese Society of Pathology and John Wiley & Sons Australia, Ltd
Citation
The 5th Asia Pacific IAP Congress, Singapore, 27-31 May 2007. In Pathology International, 2007, v. 57 n. S1, p. A26 Abstract no. 88 How to Cite?
AbstractDespite extensive research worldwide, there is no effective way tocontrol the growth of androgen-independent (AI) prostate cancer.Garlic (Allium sativum) extract has been suggested as an anti-canceragent based on a number of epidemiological studies. As is wellknown several compounds have been isolated from garlic includingthe lipid-soluble allyl sulfur compounds such as diallyl disulfide(DADS) and diallyl trisulfide (DATS) and water soluble compoundssuch as S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC).We have carried out extensive studies on the effects of SAC andSAMC on prostate cancer cell lines and found that these garlic deriv-atives suppressed prostate cancer cell proliferation, migration andinvasion. This inhibitory effect was associated with induction of mes-enchymal to epithelial transition. More importantly, the SAC andSAMC treatment led to restoration of E-cadherin expression whilethe expression of E-cadherin repressor, Snail, was downregulated.We have also evaluated the effect of these compounds on prostatecancer using a prostate cancer xenograft, CWR22R, and AI prostatecancer in nude mice. The results showed that treatment with thegarlic derivatives inhibited the growth of CWR22R without anydetectable toxic effect on nude mice. The SAC and SAMC inducedgrowth reduction was correlated with a reduction in serum PSA leveland proliferation rate of xenografts. Our results suggest that thesegarlic derivatives may be potential therapeutic agents for the sup-pression of AI prostate cancer.Supported by AICR (05A006-REV2) and RGC grants(HKU7478/03M) to XHW and YCW (HKU7490.03M, 7470/04M,NSFC/RGCN HKU738/03, HKU Foundation Seed Fund, 03).
Persistent Identifierhttp://hdl.handle.net/10722/95076
ISSN
2015 SCImago Journal Rankings: 0.746

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_HK
dc.contributor.authorChu, Qen_HK
dc.contributor.authorLee, DTWen_HK
dc.contributor.authorWang, Xen_HK
dc.date.accessioned2010-09-25T15:50:54Z-
dc.date.available2010-09-25T15:50:54Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 5th Asia Pacific IAP Congress, Singapore, 27-31 May 2007. In Pathology International, 2007, v. 57 n. S1, p. A26 Abstract no. 88en_HK
dc.identifier.issn1440-1827-
dc.identifier.urihttp://hdl.handle.net/10722/95076-
dc.description.abstractDespite extensive research worldwide, there is no effective way tocontrol the growth of androgen-independent (AI) prostate cancer.Garlic (Allium sativum) extract has been suggested as an anti-canceragent based on a number of epidemiological studies. As is wellknown several compounds have been isolated from garlic includingthe lipid-soluble allyl sulfur compounds such as diallyl disulfide(DADS) and diallyl trisulfide (DATS) and water soluble compoundssuch as S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC).We have carried out extensive studies on the effects of SAC andSAMC on prostate cancer cell lines and found that these garlic deriv-atives suppressed prostate cancer cell proliferation, migration andinvasion. This inhibitory effect was associated with induction of mes-enchymal to epithelial transition. More importantly, the SAC andSAMC treatment led to restoration of E-cadherin expression whilethe expression of E-cadherin repressor, Snail, was downregulated.We have also evaluated the effect of these compounds on prostatecancer using a prostate cancer xenograft, CWR22R, and AI prostatecancer in nude mice. The results showed that treatment with thegarlic derivatives inhibited the growth of CWR22R without anydetectable toxic effect on nude mice. The SAC and SAMC inducedgrowth reduction was correlated with a reduction in serum PSA leveland proliferation rate of xenografts. Our results suggest that thesegarlic derivatives may be potential therapeutic agents for the sup-pression of AI prostate cancer.Supported by AICR (05A006-REV2) and RGC grants(HKU7478/03M) to XHW and YCW (HKU7490.03M, 7470/04M,NSFC/RGCN HKU738/03, HKU Foundation Seed Fund, 03).-
dc.languageengen_HK
dc.publisherJapanese Society of Pathology and John Wiley & Sons Australia, Ltd-
dc.relation.ispartofPathology Internationalen_HK
dc.titleDerivatives of garlic inhibit prostate cancer cell growth under in vitro and in vivo conditionsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWong, YC: ycwong@hkucc.hku.hken_HK
dc.identifier.emailLee, DTW: dtwlee@HKUCC.hku.hken_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1827.2007.02113_10.x-
dc.identifier.hkuros147358en_HK
dc.identifier.volume57en_HK
dc.identifier.spage26en_HK

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