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Conference Paper: Olfactory tract transection enhances adult neurogenesis in piriform cortex

TitleOlfactory tract transection enhances adult neurogenesis in piriform cortex
Authors
Issue Date2009
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1471-4159
Citation
The 22nd Biennial Meeting of the ISN/APSN, Busan, South Korea, 23-28 August 2009. In Journal of Neurochemistry, 2009, v. 110 n. S2, p. 32 How to Cite?
AbstractAdult neurogenesis happens continuously in olfactory bulb. Loss of sensory input to the olfactory bulb leads to decreased formation of new neurons in the bulb. Piriform cortex receives projection from ipsilateral olfactory bulb, and previous studies proved the existence of new neurons in adult piriform cortex under physiological conditions. However the effects of olfactory bulb input deprivation on adult neurogenesis in rat piriform cortex have not been investigated before. The existence of neuronal progenitor cells in adult rat piriform cortex were confirmed with Bromodeoxyuridine (BrdU) labeling and early neuronal markers such as doublecortin (DCX) and Polysialic Acid-NCAM (PSA-NCAM). Sensory deprivation to the piriform cortex achieved by transection of the olfactory tract at the caudal part of one olfactory bulb, before the frontal sinus, leads to a significant increase (~60%) of doublecortin positive cells in the ipsilateral piriform cortex compared with the contralateral (intact) side. Because deafferentation causes cell apoptosis, it is possible that deafferentation or local cell death can enhance the recruitment of new neurons in the piriform cortex.
Persistent Identifierhttp://hdl.handle.net/10722/95068
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.021

 

DC FieldValueLanguage
dc.contributor.authorYuan, T-
dc.contributor.authorLiang, Y-
dc.contributor.authorTay, DKC-
dc.contributor.authorSo, KF-
dc.contributor.authorEllis-Behnke, RG-
dc.date.accessioned2010-09-25T15:50:39Z-
dc.date.available2010-09-25T15:50:39Z-
dc.date.issued2009-
dc.identifier.citationThe 22nd Biennial Meeting of the ISN/APSN, Busan, South Korea, 23-28 August 2009. In Journal of Neurochemistry, 2009, v. 110 n. S2, p. 32-
dc.identifier.issn0022-3042-
dc.identifier.urihttp://hdl.handle.net/10722/95068-
dc.description.abstractAdult neurogenesis happens continuously in olfactory bulb. Loss of sensory input to the olfactory bulb leads to decreased formation of new neurons in the bulb. Piriform cortex receives projection from ipsilateral olfactory bulb, and previous studies proved the existence of new neurons in adult piriform cortex under physiological conditions. However the effects of olfactory bulb input deprivation on adult neurogenesis in rat piriform cortex have not been investigated before. The existence of neuronal progenitor cells in adult rat piriform cortex were confirmed with Bromodeoxyuridine (BrdU) labeling and early neuronal markers such as doublecortin (DCX) and Polysialic Acid-NCAM (PSA-NCAM). Sensory deprivation to the piriform cortex achieved by transection of the olfactory tract at the caudal part of one olfactory bulb, before the frontal sinus, leads to a significant increase (~60%) of doublecortin positive cells in the ipsilateral piriform cortex compared with the contralateral (intact) side. Because deafferentation causes cell apoptosis, it is possible that deafferentation or local cell death can enhance the recruitment of new neurons in the piriform cortex.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1471-4159-
dc.relation.ispartofJournal of Neurochemistry-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article].-
dc.titleOlfactory tract transection enhances adult neurogenesis in piriform cortex-
dc.typeConference_Paper-
dc.identifier.emailLiang, Y: yxliang@HKUCC.hku.hk-
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hk-
dc.identifier.emailEllis-Behnke, RG: rutledge@HKUCC.hku.hk-
dc.identifier.authorityLiang, Y=rp00510-
dc.identifier.authorityTay, DKC=rp00336-
dc.identifier.authoritySo, KF=rp00329-
dc.identifier.authorityEllis-Behnke, RG=rp00252-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1471-4159.2009.06238.x-
dc.identifier.hkuros162721-
dc.identifier.volume110-
dc.identifier.issueS2-
dc.identifier.spage32-
dc.identifier.epage32-
dc.publisher.placeUnited Kingdom-

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