File Download

There are no files associated with this item.

Supplementary

Conference Paper: The aqueous extract from anti-aging Ganoderma lucidum inhibits beta-amyloid peptide-induced neurotoxicity

TitleThe aqueous extract from anti-aging Ganoderma lucidum inhibits beta-amyloid peptide-induced neurotoxicity
Authors
Issue Date2006
PublisherSociety for Neuroscience
Citation
Society for Neuroscience Annual Meeting, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 826.11/CC29 How to Cite?
AbstractGanoderma lucidum (Lingzhi) is an anti-aging oriental medicine that has been used for centuries in China to promote health. Numerous studies have reported the immunoregulatory and anti-tumor activities of G. lucidum. Although G. lucidum exhibits a wide array of effects on cancer and immune system, only few biological effects are known in the nervous system. We, therefore, take initiative to investigate its potential neuroprotective effects. Our results demonstrated that aqueous extract of G. lucidum exhibited neuroprotective effects against β-amyloid peptide (Aβ), 6-hydroxdopamine (6-OHDA) and staurosporine in differentiated human neuroblastoma SH-SY5Y. Since Aβ peptide plays significant roles in pathogenesis of Alzheimer’s disease, we have further investigated the neuroprotective effects of G. lucidum against Aβ toxicity by using primary cultures of cortical neurons. Pre-treatment of G. lucidum aqueous extract significantly attenuated Aβ-induced DEVD- (caspase-3 like) cleavage activities in a dose-dependent manner. In addition, aqueous extract of G. lucidum attenuated Aβ-induced synaptotoxicity by examining pre-synaptic synaptophysin immunoreactivity. Furthermore, treatment of G. lucidum aqueous extract attenuated the phosphorylation of c-Jun N-terminal kinase (JNK), c-Jun II and p38 MAPK in Aβ-stressed neurons. Together our previous study on anti-aging oriental medicine, G. lucidum is another example exhibiting neuroprotective effects and potential to be developed as neuroprotective agent.
Persistent Identifierhttp://hdl.handle.net/10722/95060

 

DC FieldValueLanguage
dc.contributor.authorLai, SWen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorZee, SSYen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T15:50:24Z-
dc.date.available2010-09-25T15:50:24Z-
dc.date.issued2006en_HK
dc.identifier.citationSociety for Neuroscience Annual Meeting, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 826.11/CC29en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95060-
dc.description.abstractGanoderma lucidum (Lingzhi) is an anti-aging oriental medicine that has been used for centuries in China to promote health. Numerous studies have reported the immunoregulatory and anti-tumor activities of G. lucidum. Although G. lucidum exhibits a wide array of effects on cancer and immune system, only few biological effects are known in the nervous system. We, therefore, take initiative to investigate its potential neuroprotective effects. Our results demonstrated that aqueous extract of G. lucidum exhibited neuroprotective effects against β-amyloid peptide (Aβ), 6-hydroxdopamine (6-OHDA) and staurosporine in differentiated human neuroblastoma SH-SY5Y. Since Aβ peptide plays significant roles in pathogenesis of Alzheimer’s disease, we have further investigated the neuroprotective effects of G. lucidum against Aβ toxicity by using primary cultures of cortical neurons. Pre-treatment of G. lucidum aqueous extract significantly attenuated Aβ-induced DEVD- (caspase-3 like) cleavage activities in a dose-dependent manner. In addition, aqueous extract of G. lucidum attenuated Aβ-induced synaptotoxicity by examining pre-synaptic synaptophysin immunoreactivity. Furthermore, treatment of G. lucidum aqueous extract attenuated the phosphorylation of c-Jun N-terminal kinase (JNK), c-Jun II and p38 MAPK in Aβ-stressed neurons. Together our previous study on anti-aging oriental medicine, G. lucidum is another example exhibiting neuroprotective effects and potential to be developed as neuroprotective agent.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleThe aqueous extract from anti-aging Ganoderma lucidum inhibits beta-amyloid peptide-induced neurotoxicityen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYuen, WH: whyuen@srpdfond.comen_HK
dc.identifier.emailZee, SSY: botanya@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.hkuros124932en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats