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Conference Paper: Polysaccharides from Wolfberry (Lycium barbarum) antagonize homocysteine-induced neurotoxicity in cultured cortical neurons

TitlePolysaccharides from Wolfberry (Lycium barbarum) antagonize homocysteine-induced neurotoxicity in cultured cortical neurons
Authors
Keywordshomocysteine
tau
wolfberry
Issue Date2009
PublisherSociety for Neuroscience.
Citation
The 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009, Program#/Poster#: 626.3/H16 How to Cite?
AbstractElevation of plasma homocysteine (Hcy) level is associated with a number of neurological disorders including Alzheimer’s disease (AD). The underlying mechanisms remain unclear. It has been suggested that high level of Hcy could induce AD-like neuropathology such as tau phosphorylation and increase Aβ production. Wolfberry (Lycium barbarum) is an oriental herb that is famous for its eye-protecting and anti-aging properties. Previous studies suggested that its polysaccharides, named as LBA, can protect neurons against Aβ and glutamate neurotoxicity. In this study, we investigate the possible protective effects of LBA on Hcy neurotoxicity. We found that treatment of LBA reduced Hcy-induced cell death and apoptosis in primary cortical neurons. LBA also attenuated Hcy-induced tau cleavage and tau phosphorylation at tau-1 (Ser198/199/202), pS396 (Ser396) and pS404 (Ser404) epitopes. The level of p-GSK3β (Ser9/Tyr216) remained relatively unchanged in all detected time points. Treatment of LBA significantly suppressed Hcy-induced elevation of p-JNK and p-ERK. Taken together, our results show that LBA can protect neurons from Hcy toxicity. Its potential to act as a disease-modifying agent in the prevention of AD deserves further exploration.
Persistent Identifierhttp://hdl.handle.net/10722/95011

 

DC FieldValueLanguage
dc.contributor.authorHo, YSen_HK
dc.contributor.authorYang, Xen_HK
dc.contributor.authorYu, MSen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T15:48:51Z-
dc.date.available2010-09-25T15:48:51Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009, Program#/Poster#: 626.3/H16en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95011-
dc.description.abstractElevation of plasma homocysteine (Hcy) level is associated with a number of neurological disorders including Alzheimer’s disease (AD). The underlying mechanisms remain unclear. It has been suggested that high level of Hcy could induce AD-like neuropathology such as tau phosphorylation and increase Aβ production. Wolfberry (Lycium barbarum) is an oriental herb that is famous for its eye-protecting and anti-aging properties. Previous studies suggested that its polysaccharides, named as LBA, can protect neurons against Aβ and glutamate neurotoxicity. In this study, we investigate the possible protective effects of LBA on Hcy neurotoxicity. We found that treatment of LBA reduced Hcy-induced cell death and apoptosis in primary cortical neurons. LBA also attenuated Hcy-induced tau cleavage and tau phosphorylation at tau-1 (Ser198/199/202), pS396 (Ser396) and pS404 (Ser404) epitopes. The level of p-GSK3β (Ser9/Tyr216) remained relatively unchanged in all detected time points. Treatment of LBA significantly suppressed Hcy-induced elevation of p-JNK and p-ERK. Taken together, our results show that LBA can protect neurons from Hcy toxicity. Its potential to act as a disease-modifying agent in the prevention of AD deserves further exploration.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.rightsNeuroscience 2009. Copyright © Society for Neuroscience.-
dc.subjecthomocysteine-
dc.subjecttau-
dc.subjectwolfberry-
dc.titlePolysaccharides from Wolfberry (Lycium barbarum) antagonize homocysteine-induced neurotoxicity in cultured cortical neuronsen_HK
dc.typeConference_Paper-
dc.identifier.emailYang, X: yangxifeismile@yahoo.com.cnen_HK
dc.identifier.emailYu, MS: ymsmabel@graduate.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros168086en_HK
dc.publisher.placeUnited States-

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