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Conference Paper: Caspases inhibitors enhance regeneration of neonatal spinal motoneurons after root avulsion

TitleCaspases inhibitors enhance regeneration of neonatal spinal motoneurons after root avulsion
Authors
KeywordsACETYLCHOLINE RECEPTOR
NEUROMUSCULAR JUNCTION
REINNERVATION
SPINAL CORD INJURY
Issue Date2002
PublisherSociety for Neuroscience
Citation
Neuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 466.6 How to Cite?
AbstractWe have previously demonstrated that the administration of caspase inhibitors benzyloxycarbonyl-Asp(OMe)fluoromethylketone (Boc-D-FMK) protected the avulsed spinal motoneurons from death for more than 8 weeks while the neuroprotective effect of N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO) was only lasted for 14 days. The present study examined whether in neonatal animals, inhibition of caspases could enhance the regeneration and reinnervation of injured motoneuron. Boc-D-FMK and Ac-DEVD-CHO promoted 62% and 44% motoneuron regeneration respectively when the peripheral nerve (PN) graft was implanted immediately after the lesion. When the PN graft was implanted 2 weeks following the injury, 53% of motoneurons could regenerate their axons into the PN graft after treatment with Boc-D-FMK. In addition, 39% of the motoneuron axons were able to reinnervate the denervated biceps muscle. Some morphologically normal neuromuscular junctions were reformed through a PN bridge joining the avulsed spinal motoneurons to the biceps. Our results indicated that general caspase inhibitor is essential for the regeneration and reinnervation of the axotomized motoneurons after root avulsion in neonates. Supported by The Hong Kong Research Grants Council
Persistent Identifierhttp://hdl.handle.net/10722/94970

 

DC FieldValueLanguage
dc.contributor.authorChan, SYMen_HK
dc.contributor.authorYick, LWen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorYip, HKFen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorOppenheim, Ren_HK
dc.date.accessioned2010-09-25T15:47:35Z-
dc.date.available2010-09-25T15:47:35Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 466.6-
dc.identifier.urihttp://hdl.handle.net/10722/94970-
dc.description.abstractWe have previously demonstrated that the administration of caspase inhibitors benzyloxycarbonyl-Asp(OMe)fluoromethylketone (Boc-D-FMK) protected the avulsed spinal motoneurons from death for more than 8 weeks while the neuroprotective effect of N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO) was only lasted for 14 days. The present study examined whether in neonatal animals, inhibition of caspases could enhance the regeneration and reinnervation of injured motoneuron. Boc-D-FMK and Ac-DEVD-CHO promoted 62% and 44% motoneuron regeneration respectively when the peripheral nerve (PN) graft was implanted immediately after the lesion. When the PN graft was implanted 2 weeks following the injury, 53% of motoneurons could regenerate their axons into the PN graft after treatment with Boc-D-FMK. In addition, 39% of the motoneuron axons were able to reinnervate the denervated biceps muscle. Some morphologically normal neuromuscular junctions were reformed through a PN bridge joining the avulsed spinal motoneurons to the biceps. Our results indicated that general caspase inhibitor is essential for the regeneration and reinnervation of the axotomized motoneurons after root avulsion in neonates. Supported by The Hong Kong Research Grants Council-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectACETYLCHOLINE RECEPTOR-
dc.subjectNEUROMUSCULAR JUNCTION-
dc.subjectREINNERVATION-
dc.subjectSPINAL CORD INJURY-
dc.titleCaspases inhibitors enhance regeneration of neonatal spinal motoneurons after root avulsionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, SYM: ymchanshirley@yahoo.com.hken_HK
dc.identifier.emailYick, LW: yickkevinhk@yahoo.comen_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailYip, HKF: hkfyip@hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros95243en_HK

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