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Conference Paper: Characterization of neurodegeneration in experimental autoimmune encephalomyelitis induced rat using high resolution DTI

TitleCharacterization of neurodegeneration in experimental autoimmune encephalomyelitis induced rat using high resolution DTI
Authors
Issue Date2007
PublisherInternational Society for Magnetic Resonance in Medicine
Citation
Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 471 Abstract no. 2409 How to Cite?
AbstractExperimental autoimmune encephalomyelitis (EAE) has been successfully used as a model of multiple sclerosis. With the loss of myelin in CNS axons, the pathology involved generally affects the overall integrity of the white matter structure. In this study, radial and axial diffusivities was comprehensively determined by high-resolution DTI in the spinal cord (SC) samples of EAE induced rats, and compared to histological and behavioral analyses. Radial diffusivity was found to be sensitive to demyelination or myelin quantification. Relatively large variation of both radial and axial diffusivities was observed. In addition, SC degeneration was found to be spatially inhomogeneous. The results underscore the necessity of using volumetric DTI, and both radial and axial diffusivity analysis to accurately characterize the neurodegeneration in this disease.
Persistent Identifierhttp://hdl.handle.net/10722/94931

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_HK
dc.contributor.authorHu, Ben_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorMi, Sen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T15:46:22Z-
dc.date.available2010-09-25T15:46:22Z-
dc.date.issued2007en_HK
dc.identifier.citationJoint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 471 Abstract no. 2409-
dc.identifier.urihttp://hdl.handle.net/10722/94931-
dc.description.abstractExperimental autoimmune encephalomyelitis (EAE) has been successfully used as a model of multiple sclerosis. With the loss of myelin in CNS axons, the pathology involved generally affects the overall integrity of the white matter structure. In this study, radial and axial diffusivities was comprehensively determined by high-resolution DTI in the spinal cord (SC) samples of EAE induced rats, and compared to histological and behavioral analyses. Radial diffusivity was found to be sensitive to demyelination or myelin quantification. Relatively large variation of both radial and axial diffusivities was observed. In addition, SC degeneration was found to be spatially inhomogeneous. The results underscore the necessity of using volumetric DTI, and both radial and axial diffusivity analysis to accurately characterize the neurodegeneration in this disease.-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine-
dc.relation.ispartofJoint Annual Meeting ISMRM-ESMRMBen_HK
dc.titleCharacterization of neurodegeneration in experimental autoimmune encephalomyelitis induced rat using high resolution DTIen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authorityWu, EX=rp00193-
dc.identifier.hkuros134564en_HK
dc.identifier.hkuros141228-
dc.customcontrol.immutablesml 160114 - merged-

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