The effects of orthodontic intrusion utilising two novel osteogenic compounds on periodontal bone levels

Abstract

AIM: Naringin and quercetin are commonly found in fruit. It was observed that they have potent local osteogenic effects and are active against periodontal pathogens such as Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg). It was found they may be useful compounds in patients with certain types of periodontal bone loss; specifi cally, in patients with teeth which have extruded following periodontal attachment loss. Orthodontic intrusion followed by periodontal regeneration surgery using either naringin or quercetin could result in increased periodontal bone levels. The aims of this research were to study their effects on the growth of Aa and Pg and to highlight the osteogenic effects of these compounds. MATERIALS AND METHOD: Aa and Pg were grown in naringin and quercetin solutions and 0.2 per cent chlorhexidine (positive control) and 0.9 per cent sodium chloride (negative control) over 24 hours in an anaerobic incubator. RESULTS: Aa: growth was inhibited at 3 hours and showed an inhibitory effect for 3-12 hours. Pg: complete inhibition by 24 hours. No signifi cant difference was found between the chlorhexidine group and these solutions at 24 hours. Signifi cant reductions in cell counts were observed in the NaCl group compared with the baseline sample. CONCLUSIONS: Quercetin and naringin have an inhibitory effect on Aa and Pg.