File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Expressions of VEGF, BMP-2 and CBFA in statin-induced osteogenesis

TitleExpressions of VEGF, BMP-2 and CBFA in statin-induced osteogenesis
Authors
Issue Date2004
PublisherOxford University Press
Citation
The 80th Congress of the European Orthodontic Society, Aarhus, Denmark, 7-11 June 2004. In European Journal of Orthodontics, v. 26 n. 5, p. e82-e83 Abstract no.166 How to Cite?
AbstractAIMS: To study the expressions of VEGF, BMP-2 and Cbfa1 in statin-induced osteogenesis. MATERIALS AND METHOD: Thirty bone defects were created in the parietal bone of 15 New Zealand White rabbits. The rabbits were divided into statin (9) and collagen matrix (6) groups for further assessment. In the statin group, the defects were grafted with collagen matrix carriers mixed with statin solution. These rabbits were sacrificed on day 1, 2, 3 (2 rabbits), 4 (2 rabbits), 5 (2 rabbits) and 6 after surgery. In the collagen matrix group, the defects were grafted with collagen matrix carriers mixed with water for injection, sacrificed on day 1, 2, 3, 4, 5 and 6 after surgery. The bone defects and surrounding tissues were prepared for histological assessment. RESULTS: Immunolocalization studies on the defects grafted with statin showed VEGF was expressed on day 3 after surgery, BMP-2 on day 4, Cbfa1 on day 5 and new bone was formed on day 5. These events occurred one day earlier than those grafted with the carrier alone. CONCLUSION: Statin both induced and accelerated bone formation locally. It triggered the early expression of growth factors that regulate angiogenesis, differentiation of bone cells and osteogenesis during osteoinduction.
Persistent Identifierhttp://hdl.handle.net/10722/94582
ISSN
2015 Impact Factor: 1.44
2015 SCImago Journal Rankings: 1.090

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-25T15:35:41Z-
dc.date.available2010-09-25T15:35:41Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 80th Congress of the European Orthodontic Society, Aarhus, Denmark, 7-11 June 2004. In European Journal of Orthodontics, v. 26 n. 5, p. e82-e83 Abstract no.166en_HK
dc.identifier.issn0141-5387-
dc.identifier.urihttp://hdl.handle.net/10722/94582-
dc.description.abstractAIMS: To study the expressions of VEGF, BMP-2 and Cbfa1 in statin-induced osteogenesis. MATERIALS AND METHOD: Thirty bone defects were created in the parietal bone of 15 New Zealand White rabbits. The rabbits were divided into statin (9) and collagen matrix (6) groups for further assessment. In the statin group, the defects were grafted with collagen matrix carriers mixed with statin solution. These rabbits were sacrificed on day 1, 2, 3 (2 rabbits), 4 (2 rabbits), 5 (2 rabbits) and 6 after surgery. In the collagen matrix group, the defects were grafted with collagen matrix carriers mixed with water for injection, sacrificed on day 1, 2, 3, 4, 5 and 6 after surgery. The bone defects and surrounding tissues were prepared for histological assessment. RESULTS: Immunolocalization studies on the defects grafted with statin showed VEGF was expressed on day 3 after surgery, BMP-2 on day 4, Cbfa1 on day 5 and new bone was formed on day 5. These events occurred one day earlier than those grafted with the carrier alone. CONCLUSION: Statin both induced and accelerated bone formation locally. It triggered the early expression of growth factors that regulate angiogenesis, differentiation of bone cells and osteogenesis during osteoinduction.-
dc.languageengen_HK
dc.publisherOxford University Press-
dc.relation.ispartofEuropean Journal of Orthodonticsen_HK
dc.titleExpressions of VEGF, BMP-2 and CBFA in statin-induced osteogenesisen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWong, RWK: fyoung@hkucc.hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hkusua.hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ejo/26.5.e1-
dc.identifier.hkuros110884en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats