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Conference Paper: Genetic predisposition to a skeletal class II malocclusion in a Southern Chinese population

TitleGenetic predisposition to a skeletal class II malocclusion in a Southern Chinese population
Authors
Issue Date2009
PublisherOxford University Press
Citation
The 85th Congress of the European Orthodontic Society, Helsinki, Finland, 10 – 14 June 2009. In European Journal of Orthodontics, 2009, v. 31 n. 4, p. e42-e43 Abstract no.108 How to Cite?
AbstractAIM: To identify the genetic predisposing factors of skeletal Class II malocclusions in a southern Chinese population. SUBJECTS AND METHOD: Southern Chinese volunteers, including 198 normal sagittal skeletal subjects and 162 skeletal Class II patients, were recruited for this case-control association study. Genomic DNA was isolated from whole blood. Fiftyeight single nucleotide polymorphisms (SNPs) from eight genes, which participate in the process of mesenchymal stem cell proliferation and chondrogenesis in the mandibular condyle, were genotyped using the Sequenom platform. Association testing was performed by chi-square test. The Hardy-Weinberg equilibrium test and linkage disequilibrium test were executed with Haploview software. RESULTS: The increased susceptibility to a skeletal Class II malocclusion was found to be associated with one SNP in gene NOS3, rs3918188 (OR = 2.337 with 95% CI = 1.192-4.582 for AA, compared with CA and CC genotypes). Allele A in rs3918188 (P = 0.019, OR = 1.449 with 95% CI = 1.062-1.976) was signifi cantly associated with the trait. CONCLUSIONS: SNP rs3918188 is one predisposing factors for a skeletal Class II malocclusion in a southern Chinese population. Further studies on genetic markers may expand understanding of the genetic control in craniofacial morphological determinants and help in the prediction of craniofacial growth.
Persistent Identifierhttp://hdl.handle.net/10722/93998
ISSN
2015 Impact Factor: 1.44
2015 SCImago Journal Rankings: 1.090

 

DC FieldValueLanguage
dc.contributor.authorChen, Ken_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-25T15:18:20Z-
dc.date.available2010-09-25T15:18:20Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 85th Congress of the European Orthodontic Society, Helsinki, Finland, 10 – 14 June 2009. In European Journal of Orthodontics, 2009, v. 31 n. 4, p. e42-e43 Abstract no.108en_HK
dc.identifier.issn0141-5387-
dc.identifier.urihttp://hdl.handle.net/10722/93998-
dc.description.abstractAIM: To identify the genetic predisposing factors of skeletal Class II malocclusions in a southern Chinese population. SUBJECTS AND METHOD: Southern Chinese volunteers, including 198 normal sagittal skeletal subjects and 162 skeletal Class II patients, were recruited for this case-control association study. Genomic DNA was isolated from whole blood. Fiftyeight single nucleotide polymorphisms (SNPs) from eight genes, which participate in the process of mesenchymal stem cell proliferation and chondrogenesis in the mandibular condyle, were genotyped using the Sequenom platform. Association testing was performed by chi-square test. The Hardy-Weinberg equilibrium test and linkage disequilibrium test were executed with Haploview software. RESULTS: The increased susceptibility to a skeletal Class II malocclusion was found to be associated with one SNP in gene NOS3, rs3918188 (OR = 2.337 with 95% CI = 1.192-4.582 for AA, compared with CA and CC genotypes). Allele A in rs3918188 (P = 0.019, OR = 1.449 with 95% CI = 1.062-1.976) was signifi cantly associated with the trait. CONCLUSIONS: SNP rs3918188 is one predisposing factors for a skeletal Class II malocclusion in a southern Chinese population. Further studies on genetic markers may expand understanding of the genetic control in craniofacial morphological determinants and help in the prediction of craniofacial growth.-
dc.languageengen_HK
dc.publisherOxford University Press-
dc.relation.ispartofEuropean Journal of Orthodonticsen_HK
dc.titleGenetic predisposition to a skeletal class II malocclusion in a Southern Chinese populationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWong, RWK: fyoung@hkucc.hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hkusua.hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ejo/cjp095-
dc.identifier.hkuros157596en_HK
dc.identifier.spage142en_HK

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