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Article: Osteointegration of soft tissue grafts within the bone tunnels in anterior cruciate ligament reconstruction can be enhanced

TitleOsteointegration of soft tissue grafts within the bone tunnels in anterior cruciate ligament reconstruction can be enhanced
Authors
KeywordsAnterior cruciate ligament
Graft
Healing
Tendon
Tunnel
Issue Date2010
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/167
Citation
Knee Surgery, Sports Traumatology, Arthroscopy, 2010, v. 18 n. 8, p. 1038-1051 How to Cite?
AbstractAnterior cruciate ligament reconstruction with a soft tissue autograft (hamstring autograft) has grown in popularity in the last 10 years. However, the issues of a relatively long healing time and an inferior histological healing result in terms of Sharpey-like fibers connection in soft tissue grafts are still unsolved. To obtain a promising outcome in the long run, prompt osteointegration of the tendon graft within the bone tunnel is essential. In recent decades, numerous methods have been reported to enhance osteointegration of soft tissue graft in the bone tunnel. In this article, we review the current literature in this research area, mainly focusing on strategies applied to the local bone tunnel environment. Biological strategies such as stem cell and gene transfer technology, as well as the local application of specific growth factors have been reported to yield exciting results. The use of biological bone substitute and physical stimulation also obtained promising results. Artificially engineered tissue has promise as a solution to the problem of donor site morbidity. Despite these encouraging results, the current available evidence is still experimental. Further clinical studies in terms of randomized control trial in the future should be conducted to extrapolate these basic science study findings into clinical practice. © 2009 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/92993
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKuang, GMen_HK
dc.contributor.authorYau, WPen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChiu, KYen_HK
dc.date.accessioned2010-09-24T04:07:20Z-
dc.date.available2010-09-24T04:07:20Z-
dc.date.issued2010en_HK
dc.identifier.citationKnee Surgery, Sports Traumatology, Arthroscopy, 2010, v. 18 n. 8, p. 1038-1051en_HK
dc.identifier.issn0942-2056en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92993-
dc.description.abstractAnterior cruciate ligament reconstruction with a soft tissue autograft (hamstring autograft) has grown in popularity in the last 10 years. However, the issues of a relatively long healing time and an inferior histological healing result in terms of Sharpey-like fibers connection in soft tissue grafts are still unsolved. To obtain a promising outcome in the long run, prompt osteointegration of the tendon graft within the bone tunnel is essential. In recent decades, numerous methods have been reported to enhance osteointegration of soft tissue graft in the bone tunnel. In this article, we review the current literature in this research area, mainly focusing on strategies applied to the local bone tunnel environment. Biological strategies such as stem cell and gene transfer technology, as well as the local application of specific growth factors have been reported to yield exciting results. The use of biological bone substitute and physical stimulation also obtained promising results. Artificially engineered tissue has promise as a solution to the problem of donor site morbidity. Despite these encouraging results, the current available evidence is still experimental. Further clinical studies in terms of randomized control trial in the future should be conducted to extrapolate these basic science study findings into clinical practice. © 2009 Springer-Verlag.en_HK
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/167en_HK
dc.relation.ispartofKnee Surgery, Sports Traumatology, Arthroscopyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnterior cruciate ligamenten_HK
dc.subjectGraften_HK
dc.subjectHealingen_HK
dc.subjectTendonen_HK
dc.subjectTunnelen_HK
dc.titleOsteointegration of soft tissue grafts within the bone tunnels in anterior cruciate ligament reconstruction can be enhanceden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0942-2056&volume=18&issue=8&spage=1038&epage=1051&date=2010&atitle=Osteointegration+of+soft+tissue+grafts+within+the+bone+tunnels+in+Anterior+Cruciate+Ligament+reconstruction+can+be+enhanced-
dc.identifier.emailYau, WP:peterwpy@hkucc.hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailChiu, KY:pkychiu@hkucc.hku.hken_HK
dc.identifier.authorityYau, WP=rp00500en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00167-009-0910-1en_HK
dc.identifier.pmid19779894-
dc.identifier.scopuseid_2-s2.0-77954757383en_HK
dc.identifier.hkuros172585-
dc.identifier.hkuros188651-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954757383&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1038en_HK
dc.identifier.epage1051en_HK
dc.identifier.eissn1433-7347-
dc.identifier.isiWOS:000280137100004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridKuang, GM=16024818800en_HK
dc.identifier.scopusauthoridYau, WP=7005822441en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.citeulike5881393-

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