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Article: Evaluation of biomarkers of exposure and effect in juvenile areolated grouper (Epinephelus areolatus) on foodborne exposure to benzo[a]pyrene

TitleEvaluation of biomarkers of exposure and effect in juvenile areolated grouper (Epinephelus areolatus) on foodborne exposure to benzo[a]pyrene
Authors
KeywordsBenzo[a]pyrene
Endocrine function
Ethoxyresorufin-O-deethylase
Recovery
RNA:DNA ratio
Issue Date2003
PublisherSociety of Environmental Toxicology and Chemistry. The Journal's web site is located at http://etc.allenpress.com/
Citation
Environmental Toxicology And Chemistry, 2003, v. 22 n. 7, p. 1568-1573 How to Cite?
AbstractFood-borne benzo[a]pyrene (B[a]P) was administered daily to juvenile grouper (Epinephelus areolatus) at two environmentally realistic concentrations (a low dose of 0.25 μg B[a]P/g body wt/d and a high dose of 12.5 μg B[a]P/g body wt/d) to investigate and relate temporal changes in body burden of B[a]P, hepatic ethoxyresorufin-O-deethylase (EROD) activities, growth, RNA:DNA ratio, estradiol, testosterone, and triiodothyronine (T3). After feeding with B[a]P diets for four weeks, fish were fed with normal diet for another four weeks to study recovery of the various biomarkers during the depuration period. After one week of exposure, both body muscle B[a]P burdens and hepatic EROD activities significantly increased. Body burdens were stable in tissues until the fourth week of exposure, when concentrations in the high-dose group increased markedly, at which time a concomitant decrease in EROD was found. During the depuration period, body burdens decreased in the second week, and EROD declined in the first week. Growth and RNA:DNA ratio were unaltered. Despite large variations found in sex steroid levels, elevation of testosterone was clearly evident in the fourth week, showing that B[a]P may disrupt the balance of sex steroids in fish. Significantly, increases in plasma-free T3 concentrations were found in the fourth week of exposure and the first week of depuration, suggesting that development and reproduction may potentially be at risk during chronic exposures. Our data also suggest that these hormonal disturbances are not persistent and that normal hormonal levels can be restored soon after contamination is abated.
Persistent Identifierhttp://hdl.handle.net/10722/92775
ISSN
2015 Impact Factor: 2.763
2015 SCImago Journal Rankings: 1.523
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, RSSen_HK
dc.contributor.authorPollino, CAen_HK
dc.contributor.authorAu, DWTen_HK
dc.contributor.authorZheng, GJen_HK
dc.contributor.authorYuen, BBHen_HK
dc.contributor.authorLam, PKSen_HK
dc.date.accessioned2010-09-17T10:56:48Z-
dc.date.available2010-09-17T10:56:48Z-
dc.date.issued2003en_HK
dc.identifier.citationEnvironmental Toxicology And Chemistry, 2003, v. 22 n. 7, p. 1568-1573en_HK
dc.identifier.issn0730-7268en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92775-
dc.description.abstractFood-borne benzo[a]pyrene (B[a]P) was administered daily to juvenile grouper (Epinephelus areolatus) at two environmentally realistic concentrations (a low dose of 0.25 μg B[a]P/g body wt/d and a high dose of 12.5 μg B[a]P/g body wt/d) to investigate and relate temporal changes in body burden of B[a]P, hepatic ethoxyresorufin-O-deethylase (EROD) activities, growth, RNA:DNA ratio, estradiol, testosterone, and triiodothyronine (T3). After feeding with B[a]P diets for four weeks, fish were fed with normal diet for another four weeks to study recovery of the various biomarkers during the depuration period. After one week of exposure, both body muscle B[a]P burdens and hepatic EROD activities significantly increased. Body burdens were stable in tissues until the fourth week of exposure, when concentrations in the high-dose group increased markedly, at which time a concomitant decrease in EROD was found. During the depuration period, body burdens decreased in the second week, and EROD declined in the first week. Growth and RNA:DNA ratio were unaltered. Despite large variations found in sex steroid levels, elevation of testosterone was clearly evident in the fourth week, showing that B[a]P may disrupt the balance of sex steroids in fish. Significantly, increases in plasma-free T3 concentrations were found in the fourth week of exposure and the first week of depuration, suggesting that development and reproduction may potentially be at risk during chronic exposures. Our data also suggest that these hormonal disturbances are not persistent and that normal hormonal levels can be restored soon after contamination is abated.en_HK
dc.languageengen_HK
dc.publisherSociety of Environmental Toxicology and Chemistry. The Journal's web site is located at http://etc.allenpress.com/en_HK
dc.relation.ispartofEnvironmental Toxicology and Chemistryen_HK
dc.subjectBenzo[a]pyreneen_HK
dc.subjectEndocrine functionen_HK
dc.subjectEthoxyresorufin-O-deethylaseen_HK
dc.subjectRecoveryen_HK
dc.subjectRNA:DNA ratioen_HK
dc.titleEvaluation of biomarkers of exposure and effect in juvenile areolated grouper (Epinephelus areolatus) on foodborne exposure to benzo[a]pyreneen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_HK
dc.identifier.authorityWu, RSS=rp01398en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1897/1551-5028(2003)22<1568:EOBOEA>2.0.CO;2en_HK
dc.identifier.pmid12836983en_HK
dc.identifier.scopuseid_2-s2.0-0141447767en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141447767&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1568en_HK
dc.identifier.epage1573en_HK
dc.identifier.isiWOS:000185639200020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, RSS=7402945079en_HK
dc.identifier.scopusauthoridPollino, CA=6602351526en_HK
dc.identifier.scopusauthoridAu, DWT=7004909228en_HK
dc.identifier.scopusauthoridZheng, GJ=7402223259en_HK
dc.identifier.scopusauthoridYuen, BBH=36889321900en_HK
dc.identifier.scopusauthoridLam, PKS=7202365776en_HK

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