File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: DNA adduct formation and DNA strand breaks in green-lipped mussels (Perna viridis) exposed to benzo[a]pyrene: Dose- and time-dependent relationships

TitleDNA adduct formation and DNA strand breaks in green-lipped mussels (Perna viridis) exposed to benzo[a]pyrene: Dose- and time-dependent relationships
Authors
KeywordsBenzo[a]pyrene
DNA adducts
DNA strand breaks
Exposure duration
Green-lipped mussels
Perna viridis
Issue Date2001
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/marpolbul
Citation
Marine Pollution Bulletin, 2001, v. 42 n. 7, p. 603-610 How to Cite?
AbstractGreen-lipped mussels, Perna viridis, were exposed to 0, 0.3, 3 and 30μgl-1 (nominal concentrations) B[a]P under laboratory conditions over a period of 24 days. Mussels were collected on day 0, 1, 3, 6, 12, 18 and 24, and the levels of DNA adducts and DNA strand breaks in their hepatopancreas tissues monitored. Mussels exposed to 0.3 and 3μgl-1 B[a]P showed marked increases in strand breaks after 1 day of exposure. DNA strand break levels in these mussels remained high and significantly different from the control values until day 3 for the 0.3μgl-1 treatment group, and day 6 for the 3μgl-1 treatment group. This was followed by a gradual reduction in strand breaks. After 12 days, the levels of both groups had returned to the same level as that of the control. No increase in DNA strand breaks was observable in mussels exposed to 30μgl-1 B[a]P in the first 12 days of exposure, but a significant increase was observed from day 12 to day 24. Increasing B[a]P concentrations resulted in elevated DNA adduct levels after 3-6 days of exposure, but this pattern of dose-related increase disappeared after 12 days. These results indicate that a better understanding of the complex interactions between exposure levels and durations is crucially important before DNA adduct levels and DNA strand breaks in P. viridis can be used as effective biomarkers for monitoring genotoxicants in marine waters. Copyright © 2001 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/92737
ISSN
2015 Impact Factor: 3.099
2015 SCImago Journal Rankings: 1.264
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChing, EWKen_HK
dc.contributor.authorSiu, WHLen_HK
dc.contributor.authorLam, PKSen_HK
dc.contributor.authorXu, Len_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorRichardson, BJen_HK
dc.contributor.authorWu, RSSen_HK
dc.date.accessioned2010-09-17T10:55:41Z-
dc.date.available2010-09-17T10:55:41Z-
dc.date.issued2001en_HK
dc.identifier.citationMarine Pollution Bulletin, 2001, v. 42 n. 7, p. 603-610en_HK
dc.identifier.issn0025-326Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/92737-
dc.description.abstractGreen-lipped mussels, Perna viridis, were exposed to 0, 0.3, 3 and 30μgl-1 (nominal concentrations) B[a]P under laboratory conditions over a period of 24 days. Mussels were collected on day 0, 1, 3, 6, 12, 18 and 24, and the levels of DNA adducts and DNA strand breaks in their hepatopancreas tissues monitored. Mussels exposed to 0.3 and 3μgl-1 B[a]P showed marked increases in strand breaks after 1 day of exposure. DNA strand break levels in these mussels remained high and significantly different from the control values until day 3 for the 0.3μgl-1 treatment group, and day 6 for the 3μgl-1 treatment group. This was followed by a gradual reduction in strand breaks. After 12 days, the levels of both groups had returned to the same level as that of the control. No increase in DNA strand breaks was observable in mussels exposed to 30μgl-1 B[a]P in the first 12 days of exposure, but a significant increase was observed from day 12 to day 24. Increasing B[a]P concentrations resulted in elevated DNA adduct levels after 3-6 days of exposure, but this pattern of dose-related increase disappeared after 12 days. These results indicate that a better understanding of the complex interactions between exposure levels and durations is crucially important before DNA adduct levels and DNA strand breaks in P. viridis can be used as effective biomarkers for monitoring genotoxicants in marine waters. Copyright © 2001 Elsevier Science Ltd.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/marpolbulen_HK
dc.relation.ispartofMarine Pollution Bulletinen_HK
dc.subjectBenzo[a]pyreneen_HK
dc.subjectDNA adductsen_HK
dc.subjectDNA strand breaksen_HK
dc.subjectExposure durationen_HK
dc.subjectGreen-lipped musselsen_HK
dc.subjectPerna viridisen_HK
dc.titleDNA adduct formation and DNA strand breaks in green-lipped mussels (Perna viridis) exposed to benzo[a]pyrene: Dose- and time-dependent relationshipsen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_HK
dc.identifier.authorityWu, RSS=rp01398en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0025-326X(00)00209-5en_HK
dc.identifier.pmid11488241en_HK
dc.identifier.scopuseid_2-s2.0-0034883890en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034883890&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue7en_HK
dc.identifier.spage603en_HK
dc.identifier.epage610en_HK
dc.identifier.isiWOS:000170150300021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChing, EWK=15733702700en_HK
dc.identifier.scopusauthoridSiu, WHL=9272174300en_HK
dc.identifier.scopusauthoridLam, PKS=7202365776en_HK
dc.identifier.scopusauthoridXu, L=7404745586en_HK
dc.identifier.scopusauthoridZhang, Y=7601335907en_HK
dc.identifier.scopusauthoridRichardson, BJ=7202395817en_HK
dc.identifier.scopusauthoridWu, RSS=7402945079en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats