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Article: Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-β signaling pathway

TitleHypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-β signaling pathway
Authors
KeywordsFibrogenesis
Hepatic stellate cells
Hypoxia
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2007, v. 581 n. 2, p. 203-210 How to Cite?
AbstractHypoxia is a common environmental stress factor and is also associated with various physiological and pathological conditions such as fibrogenesis. The activation of hepatic stellate cells (HSCs) is the key event in the liver fibrogenesis. In this study, the behavior of human HSCs LX-2 in low oxygen tension (1% O 2) was analyzed. Upon hypoxia, the expression of HIF-1α and VEGF gene was induced. The result of Western blotting showed that the expression of α-SMA was increased by hypoxic stimulation. Furthermore, the expression of MMP-2 and TIMP-1 genes was increased. Hypoxia also elevated the protein expression of the collagen type I in LX-2 cells. The analysis of TGF-β/Smad signaling pathway showed that hypoxia potentiated the expression of TGF-β1 and the phosphorylation status of Smad2. Gene expression profiles of LX-2 cells induced by hypoxia were obtained by using cDNA microarray technique. © 2006 Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/92716
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShi, YFen_HK
dc.contributor.authorFong, CCen_HK
dc.contributor.authorZhang, Qen_HK
dc.contributor.authorCheung, PYen_HK
dc.contributor.authorTzang, CHen_HK
dc.contributor.authorWu, RSSen_HK
dc.contributor.authorYang, Men_HK
dc.date.accessioned2010-09-17T10:55:04Z-
dc.date.available2010-09-17T10:55:04Z-
dc.date.issued2007en_HK
dc.identifier.citationFebs Letters, 2007, v. 581 n. 2, p. 203-210en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92716-
dc.description.abstractHypoxia is a common environmental stress factor and is also associated with various physiological and pathological conditions such as fibrogenesis. The activation of hepatic stellate cells (HSCs) is the key event in the liver fibrogenesis. In this study, the behavior of human HSCs LX-2 in low oxygen tension (1% O 2) was analyzed. Upon hypoxia, the expression of HIF-1α and VEGF gene was induced. The result of Western blotting showed that the expression of α-SMA was increased by hypoxic stimulation. Furthermore, the expression of MMP-2 and TIMP-1 genes was increased. Hypoxia also elevated the protein expression of the collagen type I in LX-2 cells. The analysis of TGF-β/Smad signaling pathway showed that hypoxia potentiated the expression of TGF-β1 and the phosphorylation status of Smad2. Gene expression profiles of LX-2 cells induced by hypoxia were obtained by using cDNA microarray technique. © 2006 Federation of European Biochemical Societies.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.subjectFibrogenesisen_HK
dc.subjectHepatic stellate cellsen_HK
dc.subjectHypoxiaen_HK
dc.titleHypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-β signaling pathwayen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_HK
dc.identifier.authorityWu, RSS=rp01398en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2006.12.010en_HK
dc.identifier.pmid17187782-
dc.identifier.scopuseid_2-s2.0-33846209631en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846209631&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume581en_HK
dc.identifier.issue2en_HK
dc.identifier.spage203en_HK
dc.identifier.epage210en_HK
dc.identifier.isiWOS:000244188700006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridShi, YF=7404963405en_HK
dc.identifier.scopusauthoridFong, CC=11739503800en_HK
dc.identifier.scopusauthoridZhang, Q=35515964300en_HK
dc.identifier.scopusauthoridCheung, PY=7202595426en_HK
dc.identifier.scopusauthoridTzang, CH=6508203245en_HK
dc.identifier.scopusauthoridWu, RSS=7402945079en_HK
dc.identifier.scopusauthoridYang, M=35204210300en_HK

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