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Article: Hypoxia affects sex differentiation and development leading to a male-dominated population in zebrafish (Danio rerio)

TitleHypoxia affects sex differentiation and development leading to a male-dominated population in zebrafish (Danio rerio)
Authors
KeywordsSpecies Index: Animalia
Danio
Danio Rerio
Issue Date2006
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/est
Citation
Environmental Science And Technology, 2006, v. 40 n. 9, p. 3118-3122 How to Cite?
AbstractHypoxia is affecting thousands of square kilometers of water and has caused declines in fish populations and major changes in aquatic communities worldwide. For the first time, we report that hypoxia can affect sex differentiation and sex development of zebrafish (Danio renio), leading to a male-biased population in the F1 generation (74.4% ± 1.7% males in the hypoxic groups versus 61.9% ± 1.6% males in the normoxic groups, n = 5; p < 0.05, χ2 test). The increase in males was associated with downregulations of various genes controlling the synthesis of sex hormones (i.e., 3β-HSD, CYP11 A, CYP19A, and CYP19B) as well as an increase in the testosterone/estradiol ratio. The male-dominated populations caused by hypoxia will have reduced reproductive success, thereby threatening the sustainability of natural fish populations. © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/92703
ISSN
2015 Impact Factor: 5.393
2015 SCImago Journal Rankings: 2.664
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShang, EHHen_HK
dc.contributor.authorYu, RMKen_HK
dc.contributor.authorWu, RSSen_HK
dc.date.accessioned2010-09-17T10:54:41Z-
dc.date.available2010-09-17T10:54:41Z-
dc.date.issued2006en_HK
dc.identifier.citationEnvironmental Science And Technology, 2006, v. 40 n. 9, p. 3118-3122en_HK
dc.identifier.issn0013-936Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/92703-
dc.description.abstractHypoxia is affecting thousands of square kilometers of water and has caused declines in fish populations and major changes in aquatic communities worldwide. For the first time, we report that hypoxia can affect sex differentiation and sex development of zebrafish (Danio renio), leading to a male-biased population in the F1 generation (74.4% ± 1.7% males in the hypoxic groups versus 61.9% ± 1.6% males in the normoxic groups, n = 5; p < 0.05, χ2 test). The increase in males was associated with downregulations of various genes controlling the synthesis of sex hormones (i.e., 3β-HSD, CYP11 A, CYP19A, and CYP19B) as well as an increase in the testosterone/estradiol ratio. The male-dominated populations caused by hypoxia will have reduced reproductive success, thereby threatening the sustainability of natural fish populations. © 2006 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/esten_HK
dc.relation.ispartofEnvironmental Science and Technologyen_HK
dc.subjectSpecies Index: Animaliaen_HK
dc.subjectDanioen_HK
dc.subjectDanio Rerioen_HK
dc.titleHypoxia affects sex differentiation and development leading to a male-dominated population in zebrafish (Danio rerio)en_HK
dc.typeArticleen_HK
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_HK
dc.identifier.authorityWu, RSS=rp01398en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/es0522579en_HK
dc.identifier.pmid16719120-
dc.identifier.scopuseid_2-s2.0-33646345851en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646345851&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue9en_HK
dc.identifier.spage3118en_HK
dc.identifier.epage3122en_HK
dc.identifier.eissn1520-5851-
dc.identifier.isiWOS:000237251400046-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShang, EHH=36911956700en_HK
dc.identifier.scopusauthoridYu, RMK=9278574900en_HK
dc.identifier.scopusauthoridWu, RSS=7402945079en_HK

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