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Article: Factors affecting QuickVue Influenza A + B rapid test performance in the community setting

TitleFactors affecting QuickVue Influenza A + B rapid test performance in the community setting
Authors
KeywordsDiagnostic tests
Human influenza
Immunoassay
Sensitivity
Specificity
Viral load
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2009, v. 65 n. 1, p. 35-41 How to Cite?
AbstractRapid diagnosis of influenza can facilitate timely clinical management. We evaluated the performance of the QuickVue Influenza A + B test (Quidel, San Diego, CA) in a community setting and investigated the factors affecting test sensitivity. We recruited 1008 subjects from 30 outpatient clinics in Hong Kong between February and September 2007. Each subject provided 2 pooled pairs of nose and throat swabs; 1 pair was tested by the QuickVue rapid test on site, and the other pair was sent to a laboratory for reference tests. Among 998 enrolled subjects with valid results, the rapid test had overall sensitivity of 0.68 and specificity of 0.96 compared with viral culture. Sensitivity for both influenza A and B was significantly higher for specimens with viral loads greater than 5 log10 copies/mL. The QuickVue Influenza A + B test has similar sensitivity in point-of-care community settings to more controlled conditions. © 2009 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/92602
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142
ISI Accession Number ID
Funding AgencyGrant Number
US Centers for Disease Control and Prevention1 U01 C1000439-01
Research Fund for the Control of Infectious Disease
Food and Health Bureau, Government of the Hong KongHKU-AA-22
Area of Excellence Scheme of the Hong Kong UniversityAoE/M-12/06
Funding Information:

This work has received financial support from the US Centers for Disease Control and Prevention (grant no. 1 U01 C1000439-01), the Research Fund for the Control of Infectious Disease, Food and Health Bureau, Government of the Hong Kong SAR (grant no. HKU-AA-22), and the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant no. AoE/M-12/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorCheng, CKYen_HK
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorFang, VJen_HK
dc.contributor.authorSeto, WHen_HK
dc.contributor.authorYung, Ren_HK
dc.contributor.authorUyeki, TMen_HK
dc.contributor.authorHouck, PMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLeung, GMen_HK
dc.date.accessioned2010-09-17T10:51:23Z-
dc.date.available2010-09-17T10:51:23Z-
dc.date.issued2009en_HK
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2009, v. 65 n. 1, p. 35-41en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92602-
dc.description.abstractRapid diagnosis of influenza can facilitate timely clinical management. We evaluated the performance of the QuickVue Influenza A + B test (Quidel, San Diego, CA) in a community setting and investigated the factors affecting test sensitivity. We recruited 1008 subjects from 30 outpatient clinics in Hong Kong between February and September 2007. Each subject provided 2 pooled pairs of nose and throat swabs; 1 pair was tested by the QuickVue rapid test on site, and the other pair was sent to a laboratory for reference tests. Among 998 enrolled subjects with valid results, the rapid test had overall sensitivity of 0.68 and specificity of 0.96 compared with viral culture. Sensitivity for both influenza A and B was significantly higher for specimens with viral loads greater than 5 log10 copies/mL. The QuickVue Influenza A + B test has similar sensitivity in point-of-care community settings to more controlled conditions. © 2009 Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#-
dc.subjectDiagnostic testsen_HK
dc.subjectHuman influenzaen_HK
dc.subjectImmunoassayen_HK
dc.subjectSensitivityen_HK
dc.subjectSpecificityen_HK
dc.subjectViral loaden_HK
dc.subject.meshAntigens, Viral - analysis-
dc.subject.meshImmunoassay - methods-
dc.subject.meshInfluenza A virus - immunology - isolation and purification-
dc.subject.meshInfluenza B virus - immunology - isolation and purification-
dc.subject.meshReagent Kits, Diagnostic-
dc.titleFactors affecting QuickVue Influenza A + B rapid test performance in the community settingen_HK
dc.typeArticleen_HK
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.diagmicrobio.2009.05.003en_HK
dc.identifier.pmid19679233-
dc.identifier.scopuseid_2-s2.0-68349130676en_HK
dc.identifier.hkuros162462-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68349130676&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue1en_HK
dc.identifier.spage35en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000269243400006-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridCheng, CKY=24474272100en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridFang, VJ=24474130400en_HK
dc.identifier.scopusauthoridSeto, WH=7005799377en_HK
dc.identifier.scopusauthoridYung, R=7005594277en_HK
dc.identifier.scopusauthoridUyeki, TM=6603544967en_HK
dc.identifier.scopusauthoridHouck, PM=7004317844en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.citeulike5431166-

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