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Article: A controlled comparison of flupenthixol decanoate injections and oral amitriptyline in depressed out-patients

TitleA controlled comparison of flupenthixol decanoate injections and oral amitriptyline in depressed out-patients
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1982
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1982, v. 140 n. 3, p. 287-291 How to Cite?
AbstractSixty-eight depressed out-patients were allocated to treatment with either oral amitriptyline (75-225 mg/day) or intramuscular flupenthixol decanoate (10-30 mg every 14 days) in flexible dosage for 12 weeks under double-blind procedures. Various observer- and self-rating scales were applied before and after 2, 4, 8 and 12 weeks of treatment. Twenty-four patients completed the course of amitriptyline and 20 the course of flupenthixol. All variables improved over time, but there were no significant differences between the two drugs. The Newcastle scores pre-treatment were not related to drug response suggesting that both drugs were similarly effective across a wide spectrum of depressive disorders. Patients on amitriptyline tended to complain of dry mouth; those on flupenthixol had a higher incidence of extrapyramidal signs, the majority receiving anti-parkinsonian drugs at some time during the treatment. Flupenthixol decanoate in low dose is a useful anti-depressant, but should be restricted to short courses of treatment, to patients refractory to other treatments, and to patients suspected of poor compliance.
Persistent Identifierhttp://hdl.handle.net/10722/92595
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, Wen_HK
dc.contributor.authorYoung, JPRen_HK
dc.contributor.authorJohn, Gen_HK
dc.contributor.authorLader, MHen_HK
dc.date.accessioned2010-09-17T10:51:10Z-
dc.date.available2010-09-17T10:51:10Z-
dc.date.issued1982en_HK
dc.identifier.citationBritish Journal Of Psychiatry, 1982, v. 140 n. 3, p. 287-291en_HK
dc.identifier.issn0007-1250en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92595-
dc.description.abstractSixty-eight depressed out-patients were allocated to treatment with either oral amitriptyline (75-225 mg/day) or intramuscular flupenthixol decanoate (10-30 mg every 14 days) in flexible dosage for 12 weeks under double-blind procedures. Various observer- and self-rating scales were applied before and after 2, 4, 8 and 12 weeks of treatment. Twenty-four patients completed the course of amitriptyline and 20 the course of flupenthixol. All variables improved over time, but there were no significant differences between the two drugs. The Newcastle scores pre-treatment were not related to drug response suggesting that both drugs were similarly effective across a wide spectrum of depressive disorders. Patients on amitriptyline tended to complain of dry mouth; those on flupenthixol had a higher incidence of extrapyramidal signs, the majority receiving anti-parkinsonian drugs at some time during the treatment. Flupenthixol decanoate in low dose is a useful anti-depressant, but should be restricted to short courses of treatment, to patients refractory to other treatments, and to patients suspected of poor compliance.en_HK
dc.languageengen_HK
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_HK
dc.relation.ispartofBritish Journal of Psychiatryen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleA controlled comparison of flupenthixol decanoate injections and oral amitriptyline in depressed out-patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailTam, W: wwstam@hkucc.hku.hken_HK
dc.identifier.authorityTam, W=rp01378en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7093597-
dc.identifier.scopuseid_2-s2.0-0020070106en_HK
dc.identifier.volume140en_HK
dc.identifier.issue3en_HK
dc.identifier.spage287en_HK
dc.identifier.epage291en_HK
dc.identifier.isiWOS:A1982NE96200011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTam, W=9740867000en_HK
dc.identifier.scopusauthoridYoung, JPR=7408527793en_HK
dc.identifier.scopusauthoridJohn, G=7101865001en_HK
dc.identifier.scopusauthoridLader, MH=24355835500en_HK

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