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Article: Mortality from non-malignant respiratory diseases among people with silicosis in Hong Kong: Exposure-response analyses for exposure to silica dust

TitleMortality from non-malignant respiratory diseases among people with silicosis in Hong Kong: Exposure-response analyses for exposure to silica dust
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
PublisherB M J Publishing Group. The Journal's web site is located at http://www.occenvmed.com
Citation
Occupational And Environmental Medicine, 2007, v. 64 n. 2, p. 87-92 How to Cite?
AbstractObjectives: To examine the exposure-response relationships between various indices of exposure to silica dust and the mortality from non-malignant respiratory diseases (NMRDs) or chronic obstructive pulmonary diseases (COPDs) among a cohort of workers with silicosis in Hong Kong. Methods: The concentrations of respirable silica dust were assigned to each industry and job task according to historical industrial hygiene measurements documented previously in Hong Kong. Exposure indices included cumulative dust exposure (CDE) and mean dust concentration (MDC). Penalised smoothing spline models were used as a preliminary step to detect outliers and guide further analyses. Multiple Cox's proportional hazard models were used to estimate the dust effects on the risk of mortality from NMRDs or COPDs after truncating the highest exposures. Results: 371 of the 853 (43.49%) deaths occurring among 2789 workers with silicosis during 1981-99 were from NMRDs, and 101 (27.22%) NMRDs were COPDs. Multiple Cox's proportional hazard models showed that CDE (p = 0.009) and MDC (p<0.001) were significantly associated only with NMRD mortality. Subgroup analysis showed that deaths from NMRDs (p<0.01) and COPDs (p<0.05) were significantly associated with both CDE and MDC among underground caisson workers and among those ever employed in other occupations with high exposure to silica dust. No exposure-response relationship was observed for surface construction workers with low exposures. A clear upward trend for both NMRDs and COPDs mortality was found with increasing severity of radiological silicosis. Conclusion: This study documented an exposure-response relationship between exposure to silica dust and the risk of death from NMRDs or COPDs among workers with silicosis, except for surface construction workers with low exposures. The risk of mortality from NMRDs increased significantly with the progression of International Labor Organization categories, independent of dust effects.
Persistent Identifierhttp://hdl.handle.net/10722/92573
ISSN
2015 Impact Factor: 3.745
2015 SCImago Journal Rankings: 1.597
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, LAen_HK
dc.contributor.authorYu, ITSen_HK
dc.contributor.authorLeung, CCen_HK
dc.contributor.authorTam, Wen_HK
dc.contributor.authorWong, TWen_HK
dc.date.accessioned2010-09-17T10:50:30Z-
dc.date.available2010-09-17T10:50:30Z-
dc.date.issued2007en_HK
dc.identifier.citationOccupational And Environmental Medicine, 2007, v. 64 n. 2, p. 87-92en_HK
dc.identifier.issn1351-0711en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92573-
dc.description.abstractObjectives: To examine the exposure-response relationships between various indices of exposure to silica dust and the mortality from non-malignant respiratory diseases (NMRDs) or chronic obstructive pulmonary diseases (COPDs) among a cohort of workers with silicosis in Hong Kong. Methods: The concentrations of respirable silica dust were assigned to each industry and job task according to historical industrial hygiene measurements documented previously in Hong Kong. Exposure indices included cumulative dust exposure (CDE) and mean dust concentration (MDC). Penalised smoothing spline models were used as a preliminary step to detect outliers and guide further analyses. Multiple Cox's proportional hazard models were used to estimate the dust effects on the risk of mortality from NMRDs or COPDs after truncating the highest exposures. Results: 371 of the 853 (43.49%) deaths occurring among 2789 workers with silicosis during 1981-99 were from NMRDs, and 101 (27.22%) NMRDs were COPDs. Multiple Cox's proportional hazard models showed that CDE (p = 0.009) and MDC (p<0.001) were significantly associated only with NMRD mortality. Subgroup analysis showed that deaths from NMRDs (p<0.01) and COPDs (p<0.05) were significantly associated with both CDE and MDC among underground caisson workers and among those ever employed in other occupations with high exposure to silica dust. No exposure-response relationship was observed for surface construction workers with low exposures. A clear upward trend for both NMRDs and COPDs mortality was found with increasing severity of radiological silicosis. Conclusion: This study documented an exposure-response relationship between exposure to silica dust and the risk of death from NMRDs or COPDs among workers with silicosis, except for surface construction workers with low exposures. The risk of mortality from NMRDs increased significantly with the progression of International Labor Organization categories, independent of dust effects.en_HK
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.occenvmed.comen_HK
dc.relation.ispartofOccupational and Environmental Medicineen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleMortality from non-malignant respiratory diseases among people with silicosis in Hong Kong: Exposure-response analyses for exposure to silica dusten_HK
dc.typeArticleen_HK
dc.identifier.emailTam, W: wwstam@hkucc.hku.hken_HK
dc.identifier.authorityTam, W=rp01378en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/oem.2006.028506en_HK
dc.identifier.pmid16973737-
dc.identifier.pmcidPMC2078445-
dc.identifier.scopuseid_2-s2.0-33846994109en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846994109&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue2en_HK
dc.identifier.spage87en_HK
dc.identifier.epage92en_HK
dc.identifier.isiWOS:000243942300004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTse, LA=7004824036en_HK
dc.identifier.scopusauthoridYu, ITS=7102120508en_HK
dc.identifier.scopusauthoridLeung, CC=7402612644en_HK
dc.identifier.scopusauthoridTam, W=9740867000en_HK
dc.identifier.scopusauthoridWong, TW=7403531744en_HK

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