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Article: Isoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden

TitleIsoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden
Authors
KeywordsCarotid intima-media thickness
Flow-mediated dilation
Isoflavone
Issue Date2007
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/
Citation
American Journal Of Clinical Nutrition, 2007, v. 86 n. 4, p. 938-945 How to Cite?
AbstractBackground: Epidemiologic studies have suggested that a high phytoestrogen intake is inversely associated with cardiovascular disease risk factors and the incidence of cardiovascular events. However, the relation between the intake of isoflavone, a major component of phytoestrogen, and vascular endothelial function and the atherosclerotic burden remains unclear. Objective:Weaimed to investigate the effects of various dietary soy isoflavone intakes on brachial artery flow-mediated dilation and mean maximum carotid intima-media thickness. Design: We studied 126 consecutive patients (χ̄ ± SD age: 66.5 ± 11.1 y; 69% male) at high risk of cardiovascular events (94% had documented coronary artery disease or stroke; 44% had diabetes). A validated food-frequency questionnaire was used to estimate their dietary intake after they achieved stable dietary patterns for 3 mo. Results: The median intakes of isoflavone and soy protein were 5.5 (range: 2.2-13.3) mg/d and 1.2 (range: 0.4-2.8) g/d, respectively. Persons in the 4th quartile of daily isoflavone intake had significantly (P < 0.05) greater flow-mediated dilation - but not mean maximum carotid intima-media thickness - than did those in the lower quartiles. After adjustment for potential confounders, a higher isoflavone intake in the 4th than in the 1st quartile (>13.3 mg/d), but not a higher intake of soy protein, predicted an absolute 2.71% increase in flow-mediated dilation (relative increase: 103%; P = 0.02) and a 0.17-mm decrease in mean maximum carotid intima-media thickness (relative decrease: 14.5%; P = 0.04). Conclusion: In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden. © 2007 American Society for Nutrition.
Persistent Identifierhttp://hdl.handle.net/10722/92563
ISSN
2015 Impact Factor: 6.703
2015 SCImago Journal Rankings: 3.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, YHen_HK
dc.contributor.authorLau, KKen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorShu, XOen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-17T10:50:12Z-
dc.date.available2010-09-17T10:50:12Z-
dc.date.issued2007en_HK
dc.identifier.citationAmerican Journal Of Clinical Nutrition, 2007, v. 86 n. 4, p. 938-945en_HK
dc.identifier.issn0002-9165en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92563-
dc.description.abstractBackground: Epidemiologic studies have suggested that a high phytoestrogen intake is inversely associated with cardiovascular disease risk factors and the incidence of cardiovascular events. However, the relation between the intake of isoflavone, a major component of phytoestrogen, and vascular endothelial function and the atherosclerotic burden remains unclear. Objective:Weaimed to investigate the effects of various dietary soy isoflavone intakes on brachial artery flow-mediated dilation and mean maximum carotid intima-media thickness. Design: We studied 126 consecutive patients (χ̄ ± SD age: 66.5 ± 11.1 y; 69% male) at high risk of cardiovascular events (94% had documented coronary artery disease or stroke; 44% had diabetes). A validated food-frequency questionnaire was used to estimate their dietary intake after they achieved stable dietary patterns for 3 mo. Results: The median intakes of isoflavone and soy protein were 5.5 (range: 2.2-13.3) mg/d and 1.2 (range: 0.4-2.8) g/d, respectively. Persons in the 4th quartile of daily isoflavone intake had significantly (P < 0.05) greater flow-mediated dilation - but not mean maximum carotid intima-media thickness - than did those in the lower quartiles. After adjustment for potential confounders, a higher isoflavone intake in the 4th than in the 1st quartile (>13.3 mg/d), but not a higher intake of soy protein, predicted an absolute 2.71% increase in flow-mediated dilation (relative increase: 103%; P = 0.02) and a 0.17-mm decrease in mean maximum carotid intima-media thickness (relative decrease: 14.5%; P = 0.04). Conclusion: In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden. © 2007 American Society for Nutrition.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/en_HK
dc.relation.ispartofAmerican Journal of Clinical Nutritionen_HK
dc.subjectCarotid intima-media thicknessen_HK
dc.subjectFlow-mediated dilationen_HK
dc.subjectIsoflavoneen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshBlood Flow Velocityen_HK
dc.subject.meshBlood Pressure - drug effects - physiologyen_HK
dc.subject.meshCardiovascular Diseases - epidemiology - metabolismen_HK
dc.subject.meshCarotid Arteries - pathology - ultrasonographyen_HK
dc.subject.meshDiet Surveysen_HK
dc.subject.meshEndothelium, Vascular - drug effects - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshIsoflavones - administration & dosageen_HK
dc.subject.meshLipid Metabolism - drug effects - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSoybean Proteins - administration & dosageen_HK
dc.subject.meshSoybeans - chemistryen_HK
dc.subject.meshTunica Intima - pathology - ultrasonographyen_HK
dc.subject.meshTunica Media - pathology - ultrasonographyen_HK
dc.titleIsoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burdenen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailLau, KK:gkklau@hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authorityLau, KK=rp01499en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17921368-
dc.identifier.scopuseid_2-s2.0-35148845528en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148845528&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue4en_HK
dc.identifier.spage938en_HK
dc.identifier.epage945en_HK
dc.identifier.isiWOS:000250134600008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridLau, KK=22635159600en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridShu, XO=7102525083en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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