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Article: A longitudinal study of serial BODE indices in predicting mortality and readmissions for COPD

TitleA longitudinal study of serial BODE indices in predicting mortality and readmissions for COPD
Authors
KeywordsCOPD
Mortality
Readmissions
Serial BODE index
Issue Date2011
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 2011, v. 105 n. 2, p. 266-273 How to Cite?
AbstractIntroduction: BODE index comprises Body mass index, Obstruction of the airway [FEV1], Dyspnoea score [modified Medical Research Council questionnaire] and Exercise capacity [6 min walk test]. This study assessed the role of serial changes in BODE index in predicting mortality and readmissions of COPD patients. Methods: A prospective cohort study involving 243(208males) COPD patients hospitalized for acute exacerbations of COPD [AECOPD]. BODE index was assessed at 6 weeks(baseline), 6, 12, 18 and 24 months post hospital discharge. Mortality and readmissions in the subsequent 3 years were recorded. All the patients were managed by usual care without additional intervention. Results: The mean (SD) age and FEV1% predicted were 74.2(7.8) yrs and 51.7(21.6)% respectively. Over the 3 years, 25.1% died whereas 76.5% had at least 1 readmission for AECOPD. Baseline BODE index was predictive of both the survival and readmissions to hospital for AECOPD by Cox regression analysis (p < 0.001 for both survival and readmissions). Over 24 months, 71(40.1%), 94(53.1%), 12(6.8%) patients had increased (>1point), no change, and decreased in BODE (>1point) index respectively. Serial changes in BODE index at 6 month was marginally associated with mortality, but not at 12-, 18- and 24-month. The 6-, 12- and 24-month BODE indices were predictive of the readmissions for AECOPD when compared to baseline. Conclusion: Baseline BODE index could predict both survival and readmissions for AECOPD, whereas serial BODE indices were not predictive of survival at 3 years. Single rather than serial measurements of BODE index is sufficient for prediction of survival and readmissions for patients treated with usual care. © 2010 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/92549
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID
Funding AgencyGrant Number
Chinese University of Hong Kong
Funding Information:

The authors would like to thank Miss Mabel Tong and all the staffs of the Pulmonary Function Laboratory of the Prince of Wales Hospital in helping the assessment of the subjects. This study is supported by the Respiratory Research Fund of The Chinese University of Hong Kong

References

 

DC FieldValueLanguage
dc.contributor.authorKo, FWSen_HK
dc.contributor.authorTam, Wen_HK
dc.contributor.authorTung, AHMen_HK
dc.contributor.authorNgai, Jen_HK
dc.contributor.authorNg, SSSen_HK
dc.contributor.authorLai, Ken_HK
dc.contributor.authorAu, KFen_HK
dc.contributor.authorHui, DSCen_HK
dc.date.accessioned2010-09-17T10:49:45Z-
dc.date.available2010-09-17T10:49:45Z-
dc.date.issued2011en_HK
dc.identifier.citationRespiratory Medicine, 2011, v. 105 n. 2, p. 266-273en_HK
dc.identifier.issn0954-6111en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92549-
dc.description.abstractIntroduction: BODE index comprises Body mass index, Obstruction of the airway [FEV1], Dyspnoea score [modified Medical Research Council questionnaire] and Exercise capacity [6 min walk test]. This study assessed the role of serial changes in BODE index in predicting mortality and readmissions of COPD patients. Methods: A prospective cohort study involving 243(208males) COPD patients hospitalized for acute exacerbations of COPD [AECOPD]. BODE index was assessed at 6 weeks(baseline), 6, 12, 18 and 24 months post hospital discharge. Mortality and readmissions in the subsequent 3 years were recorded. All the patients were managed by usual care without additional intervention. Results: The mean (SD) age and FEV1% predicted were 74.2(7.8) yrs and 51.7(21.6)% respectively. Over the 3 years, 25.1% died whereas 76.5% had at least 1 readmission for AECOPD. Baseline BODE index was predictive of both the survival and readmissions to hospital for AECOPD by Cox regression analysis (p < 0.001 for both survival and readmissions). Over 24 months, 71(40.1%), 94(53.1%), 12(6.8%) patients had increased (>1point), no change, and decreased in BODE (>1point) index respectively. Serial changes in BODE index at 6 month was marginally associated with mortality, but not at 12-, 18- and 24-month. The 6-, 12- and 24-month BODE indices were predictive of the readmissions for AECOPD when compared to baseline. Conclusion: Baseline BODE index could predict both survival and readmissions for AECOPD, whereas serial BODE indices were not predictive of survival at 3 years. Single rather than serial measurements of BODE index is sufficient for prediction of survival and readmissions for patients treated with usual care. © 2010 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_HK
dc.relation.ispartofRespiratory Medicineen_HK
dc.subjectCOPDen_HK
dc.subjectMortalityen_HK
dc.subjectReadmissionsen_HK
dc.subjectSerial BODE indexen_HK
dc.titleA longitudinal study of serial BODE indices in predicting mortality and readmissions for COPDen_HK
dc.typeArticleen_HK
dc.identifier.emailTam, W: wwstam@hkucc.hku.hken_HK
dc.identifier.authorityTam, W=rp01378en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.rmed.2010.06.022en_HK
dc.identifier.pmid20655186-
dc.identifier.scopuseid_2-s2.0-78651407705en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651407705&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue2en_HK
dc.identifier.spage266en_HK
dc.identifier.epage273en_HK
dc.identifier.isiWOS:000287116100015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKo, FWS=7103224911en_HK
dc.identifier.scopusauthoridTam, W=9740867000en_HK
dc.identifier.scopusauthoridTung, AHM=15123254000en_HK
dc.identifier.scopusauthoridNgai, J=15020979600en_HK
dc.identifier.scopusauthoridNg, SSS=21233825300en_HK
dc.identifier.scopusauthoridLai, K=36930705000en_HK
dc.identifier.scopusauthoridAu, KF=37664484000en_HK
dc.identifier.scopusauthoridHui, DSC=7101862411en_HK

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