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Article: Age of menarche and the metabolic syndrome in China

TitleAge of menarche and the metabolic syndrome in China
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.epidem.com
Citation
Epidemiology, 2007, v. 18 n. 6, p. 740-746 How to Cite?
AbstractOBJECTIVES: In western populations, young age of menarche is associated with increased cardiovascular risk. Little is known about the potential impact of menarche on the metabolic syndrome (as a proxy for cardiovascular risk) in rapidly economically developing populations where age of menarche is falling. We sought to determine the relation between age of menarche and the metabolic syndrome in a rapidly developing Chinese population. METHODS: We carried out a retrospective historical cohort study of 7349 women from the Guangzhou Biobank Cohort Study, China, enrolled in 2003-2004. Cardiovascular risk factors were obtained from physical examination; age of menarche was obtained from self-report. The main outcome measure was the metabolic syndrome and its components. RESULTS: Adjusted for age, education, and number of pregnancies, young age of menarche (<12.5 years) compared with age of menarche ≤14.5 years was associated with a higher risk of the metabolic syndrome (odds ratio = 1.49; 95% confidence interval = 1.22-1.82), central obesity (1.35; 1.10-1.65), raised blood pressure (1.34; 1.09-1.65), raised fasting glucose (1.40; 1.15-1.71), and higher triglyceride levels (1.36; 1.12-1.67). Further adjustment by waist circumference attenuated these effects, but the odds ratios remained elevated. CONCLUSIONS: Earlier age of menarche experienced by younger women in China today, now 12.5 years on average in urban populations, may contribute to an increase in the metabolic syndrome and thereby an increase in cardiovascular disease as these women age. These results further highlight the importance of childhood antecedents of adulthood disease. © 2007 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/92542
ISSN
2015 Impact Factor: 6.075
2015 SCImago Journal Rankings: 2.981
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Development and Research, Hong Kong
University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, Birmingham, UK
Funding Information:

Supported by The University of Hong Kong Foundation for Development and Research, Hong Kong; The University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, Birmingham, UK.

References

 

DC FieldValueLanguage
dc.contributor.authorHeys, Men_HK
dc.contributor.authorSchooling, CMen_HK
dc.contributor.authorJiang, Cen_HK
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorLao, Xen_HK
dc.contributor.authorZhang, Wen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorAdab, Pen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLeung, GMen_HK
dc.date.accessioned2010-09-17T10:49:32Z-
dc.date.available2010-09-17T10:49:32Z-
dc.date.issued2007en_HK
dc.identifier.citationEpidemiology, 2007, v. 18 n. 6, p. 740-746en_HK
dc.identifier.issn1044-3983en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92542-
dc.description.abstractOBJECTIVES: In western populations, young age of menarche is associated with increased cardiovascular risk. Little is known about the potential impact of menarche on the metabolic syndrome (as a proxy for cardiovascular risk) in rapidly economically developing populations where age of menarche is falling. We sought to determine the relation between age of menarche and the metabolic syndrome in a rapidly developing Chinese population. METHODS: We carried out a retrospective historical cohort study of 7349 women from the Guangzhou Biobank Cohort Study, China, enrolled in 2003-2004. Cardiovascular risk factors were obtained from physical examination; age of menarche was obtained from self-report. The main outcome measure was the metabolic syndrome and its components. RESULTS: Adjusted for age, education, and number of pregnancies, young age of menarche (<12.5 years) compared with age of menarche ≤14.5 years was associated with a higher risk of the metabolic syndrome (odds ratio = 1.49; 95% confidence interval = 1.22-1.82), central obesity (1.35; 1.10-1.65), raised blood pressure (1.34; 1.09-1.65), raised fasting glucose (1.40; 1.15-1.71), and higher triglyceride levels (1.36; 1.12-1.67). Further adjustment by waist circumference attenuated these effects, but the odds ratios remained elevated. CONCLUSIONS: Earlier age of menarche experienced by younger women in China today, now 12.5 years on average in urban populations, may contribute to an increase in the metabolic syndrome and thereby an increase in cardiovascular disease as these women age. These results further highlight the importance of childhood antecedents of adulthood disease. © 2007 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.epidem.comen_HK
dc.relation.ispartofEpidemiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshChilden_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMenarcheen_HK
dc.subject.meshMetabolic Syndrome X - diagnosis - epidemiology - etiology - physiopathologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPhysical Examinationen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRisk Assessmenten_HK
dc.titleAge of menarche and the metabolic syndrome in Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailHeys, M: m_heys@lycos.comen_HK
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hken_HK
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.authorityHeys, M=rp00257en_HK
dc.identifier.authoritySchooling, CM=rp00504en_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/EDE.0b013e3181567fafen_HK
dc.identifier.pmid17917601-
dc.identifier.scopuseid_2-s2.0-37349056086en_HK
dc.identifier.hkuros139120-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37349056086&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue6en_HK
dc.identifier.spage740en_HK
dc.identifier.epage746en_HK
dc.identifier.isiWOS:000262285900015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHeys, M=22234232400en_HK
dc.identifier.scopusauthoridSchooling, CM=12808565000en_HK
dc.identifier.scopusauthoridJiang, C=10639500500en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.scopusauthoridLao, X=14031637000en_HK
dc.identifier.scopusauthoridZhang, W=13410704100en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridAdab, P=6601949045en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK

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