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Article: Gene expression patterns in pancreatic tumors, cells and tissues

TitleGene expression patterns in pancreatic tumors, cells and tissues
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2007, v. 2 n. 3 How to Cite?
AbstractBackground. Cancers of the pancreas originate from both the endocrine and exocrine elements of the organ, and represent a major cause of cancer-related death. This study provides a comprehensive assessment of gene expression for pancreatic tumors, the normal pancreas, and nonneoplastic pancreatic disease. Methods/Results. DNA microarrays were used to assess the gene expression for surgically derived pancreatic adenocarcinomas, islet cell tumors, and mesenchymal tumors. The addition of normal pancreata, isolated islets, isolated pancreatic ducts, and pancreatic adenocarcinoma cell lines enhanced subsequent analysis by increasing the diversity in gene expression profiles obtained. Exocrine, endocrine, and mesenchymal tumors displayed unique gene expression profiles. Similarities in gene expression support the pancreatic duct as the origin of adenocarcinomas. In addition, genes highly expressed in other cancers and associated with specific signal transduction pathways were also found in pancreatic tumors. Conclusion. The scope of the present work was enhanced by the inclusion of publicly available datasets that encompass a wide spectrum of human tissues and enabled the identification of candidate genes that may serve diagnostic and therapeutic goals. © 2007 Lowe et al.
Persistent Identifierhttp://hdl.handle.net/10722/92530
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Susan E. Riley Family Foundation
Lustgarten Foundation
NCICA77097
HHMI
General Medical Research Service
Howard Hughes Medical Institute
Funding Information:

The Susan E. Riley Family Foundation (AWL and POB), The Lustgarten Foundation (AWL), NCI grant CA77097 and HHMI (POB), General Medical Research Service of the Department of Veterans Affairs (SPL). POB is an investigator of the Howard Hughes Medical Institute. The study sponsors had no role in the study design, data collection, analysis, interpretation of the data, writing of the paper, or the decision to submit for publication.

References

 

DC FieldValueLanguage
dc.contributor.authorLowe, AWen_HK
dc.contributor.authorOlsen, Men_HK
dc.contributor.authorHao, Yen_HK
dc.contributor.authorLee, SPen_HK
dc.contributor.authorLee, KTen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorvan de Rijn, Men_HK
dc.contributor.authorBrown, POen_HK
dc.date.accessioned2010-09-17T10:49:02Z-
dc.date.available2010-09-17T10:49:02Z-
dc.date.issued2007en_HK
dc.identifier.citationPlos One, 2007, v. 2 n. 3en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92530-
dc.description.abstractBackground. Cancers of the pancreas originate from both the endocrine and exocrine elements of the organ, and represent a major cause of cancer-related death. This study provides a comprehensive assessment of gene expression for pancreatic tumors, the normal pancreas, and nonneoplastic pancreatic disease. Methods/Results. DNA microarrays were used to assess the gene expression for surgically derived pancreatic adenocarcinomas, islet cell tumors, and mesenchymal tumors. The addition of normal pancreata, isolated islets, isolated pancreatic ducts, and pancreatic adenocarcinoma cell lines enhanced subsequent analysis by increasing the diversity in gene expression profiles obtained. Exocrine, endocrine, and mesenchymal tumors displayed unique gene expression profiles. Similarities in gene expression support the pancreatic duct as the origin of adenocarcinomas. In addition, genes highly expressed in other cancers and associated with specific signal transduction pathways were also found in pancreatic tumors. Conclusion. The scope of the present work was enhanced by the inclusion of publicly available datasets that encompass a wide spectrum of human tissues and enabled the identification of candidate genes that may serve diagnostic and therapeutic goals. © 2007 Lowe et al.en_HK
dc.languageengen_HK
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleGene expression patterns in pancreatic tumors, cells and tissuesen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0000323en_HK
dc.identifier.pmid17389914-
dc.identifier.pmcidPMC1824711-
dc.identifier.scopuseid_2-s2.0-40749106656en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40749106656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue3en_HK
dc.identifier.isiWOS:000207445200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLowe, AW=7202836976en_HK
dc.identifier.scopusauthoridOlsen, M=8752659800en_HK
dc.identifier.scopusauthoridHao, Y=26632824800en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK
dc.identifier.scopusauthoridLee, KT=35215481700en_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridvan de Rijn, M=7005571510en_HK
dc.identifier.scopusauthoridBrown, PO=35414776900en_HK

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