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Article: Peripheral amyloid-β levels regulate amyloid-β clearance from the central nervous system

TitlePeripheral amyloid-β levels regulate amyloid-β clearance from the central nervous system
Authors
KeywordsAlzheimer's disease
Blood-brain-barrier
Hepatic clearance
Liver
Passive immunization
Peripheral sink
Issue Date2009
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal Of Alzheimer's Disease, 2009, v. 16 n. 2, p. 325-329 How to Cite?
AbstractAmyloid-β (Aβ) is cleared from the brain by both proteolytic digestion and transport across the blood-brain-barrier into the peripheral circulatory system. To investigate the role peripheral Aβ levels play in regulating Aβ brain clearance, we measured the clearance of [125I]-Aβ-{1-40 injected into the brains of liver-ligated rats that allowed peripheral Aβ levels to be maintained at elevated levels for approximately one hour with/without a single peripheral bolus of unlabeled Aβ-{1-40. We found that elevating peripheral Aβlevels significantly decreased [125I]-Aβ-{1-40 brain clearance, thus supporting the hypothesis that peripheral Aβ levels regulate Aβ clearance from the central nervous system. © 2009 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/92527
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Veterans Affairs Office of Research and Development Medical Research Serve
NIHT32 AG000258
Funding Information:

This work was supported by a grant to DGC from the Veterans Affairs Office of Research and Development Medical Research Serve and an NIH fellowship to MAM (T32 AG000258).

References

 

DC FieldValueLanguage
dc.contributor.authorMarques, MAen_HK
dc.contributor.authorKulstad, JJen_HK
dc.contributor.authorSavard, CEen_HK
dc.contributor.authorGreen, PSen_HK
dc.contributor.authorLee, SPen_HK
dc.contributor.authorCraft, Sen_HK
dc.contributor.authorWatson, GSen_HK
dc.contributor.authorCook, DGen_HK
dc.date.accessioned2010-09-17T10:48:56Z-
dc.date.available2010-09-17T10:48:56Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Alzheimer's Disease, 2009, v. 16 n. 2, p. 325-329en_HK
dc.identifier.issn1387-2877en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92527-
dc.description.abstractAmyloid-β (Aβ) is cleared from the brain by both proteolytic digestion and transport across the blood-brain-barrier into the peripheral circulatory system. To investigate the role peripheral Aβ levels play in regulating Aβ brain clearance, we measured the clearance of [125I]-Aβ-{1-40 injected into the brains of liver-ligated rats that allowed peripheral Aβ levels to be maintained at elevated levels for approximately one hour with/without a single peripheral bolus of unlabeled Aβ-{1-40. We found that elevating peripheral Aβlevels significantly decreased [125I]-Aβ-{1-40 brain clearance, thus supporting the hypothesis that peripheral Aβ levels regulate Aβ clearance from the central nervous system. © 2009 - IOS Press and the authors. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_HK
dc.relation.ispartofJournal of Alzheimer's Diseaseen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectBlood-brain-barrieren_HK
dc.subjectHepatic clearanceen_HK
dc.subjectLiveren_HK
dc.subjectPassive immunizationen_HK
dc.subjectPeripheral sinken_HK
dc.titlePeripheral amyloid-β levels regulate amyloid-β clearance from the central nervous systemen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/JAD-2009-0964en_HK
dc.identifier.pmid19221422-
dc.identifier.pmcidPMC3066174-
dc.identifier.scopuseid_2-s2.0-60349121976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60349121976&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue2en_HK
dc.identifier.spage325en_HK
dc.identifier.epage329en_HK
dc.identifier.isiWOS:000264288800010-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMarques, MA=7201744054en_HK
dc.identifier.scopusauthoridKulstad, JJ=8915650600en_HK
dc.identifier.scopusauthoridSavard, CE=6701738621en_HK
dc.identifier.scopusauthoridGreen, PS=7402935660en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK
dc.identifier.scopusauthoridCraft, S=7007034447en_HK
dc.identifier.scopusauthoridWatson, GS=8915650100en_HK
dc.identifier.scopusauthoridCook, DG=7403472346en_HK

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