File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cholestan-3β,5α,6β-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells

TitleCholestan-3β,5α,6β-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells
Authors
KeywordsCholesterol
Cytotoxicity
Epithelial cell
Gallbladder
Mucin secretion
Oxysterol
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2000, v. 478 n. 1-2, p. 113-118 How to Cite?
AbstractIn order to investigate oxysterol-mediated effects on the biliary system, we studied the effects of cholestan-3β,5α,6β-triol (TriolC) and 7-ketocholesterol (7KC) on gallbladder epithelial cells. We compared their cell proliferation effects in cultured dog gallbladder epithelial cells (DGBE) to their effects in cultured human pulmonary artery endothelial cells (HPAE). Oxysterols inhibited cell proliferation in a dose-dependent fashion. Oxysterols inhibited cell growth to 50% of control at a higher dose for DGBE cells than for HPAE cells. TriolC was more cytotoxic than 7KC. We also investigated the effect of oxysterols on bile salt-induced mucin secretion by DGBE cells. TriolC suppressed mucin secretion by DGBE cells, whereas 7KC did not. These findings support the hypothesis that biliary oxysterols affect gallbladder mucosal function. Copyright (C) 2000 Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/92519
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYoshida, Ten_HK
dc.contributor.authorKlinkspoor, JHen_HK
dc.contributor.authorKuver, Ren_HK
dc.contributor.authorWrenn, SPen_HK
dc.contributor.authorKaler, EWen_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:48:42Z-
dc.date.available2010-09-17T10:48:42Z-
dc.date.issued2000en_HK
dc.identifier.citationFebs Letters, 2000, v. 478 n. 1-2, p. 113-118en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92519-
dc.description.abstractIn order to investigate oxysterol-mediated effects on the biliary system, we studied the effects of cholestan-3β,5α,6β-triol (TriolC) and 7-ketocholesterol (7KC) on gallbladder epithelial cells. We compared their cell proliferation effects in cultured dog gallbladder epithelial cells (DGBE) to their effects in cultured human pulmonary artery endothelial cells (HPAE). Oxysterols inhibited cell proliferation in a dose-dependent fashion. Oxysterols inhibited cell growth to 50% of control at a higher dose for DGBE cells than for HPAE cells. TriolC was more cytotoxic than 7KC. We also investigated the effect of oxysterols on bile salt-induced mucin secretion by DGBE cells. TriolC suppressed mucin secretion by DGBE cells, whereas 7KC did not. These findings support the hypothesis that biliary oxysterols affect gallbladder mucosal function. Copyright (C) 2000 Federation of European Biochemical Societies.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.subjectCholesterolen_HK
dc.subjectCytotoxicityen_HK
dc.subjectEpithelial cellen_HK
dc.subjectGallbladderen_HK
dc.subjectMucin secretionen_HK
dc.subjectOxysterolen_HK
dc.titleCholestan-3β,5α,6β-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-5793(00)01831-7en_HK
dc.identifier.pmid10922480en_HK
dc.identifier.scopuseid_2-s2.0-0034725459en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034725459&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume478en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage113en_HK
dc.identifier.epage118en_HK
dc.identifier.isiWOS:000088644200023-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridYoshida, T=7501317704en_HK
dc.identifier.scopusauthoridKlinkspoor, JH=6602590656en_HK
dc.identifier.scopusauthoridKuver, R=6701723533en_HK
dc.identifier.scopusauthoridWrenn, SP=6603940041en_HK
dc.identifier.scopusauthoridKaler, EW=7007157989en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats