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Article: Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States

TitleElevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 2006, v. 43 n. 5, p. 1145-1151 How to Cite?
AbstractIn the United States, elevated serum alanine aminotransferase (ALT) activity in the absence of viral hepatitis or excessive alcohol consumption is most commonly attributed to nonalcoholic fatty liver disease (NAFLD). NAFLD is related to predictors of coronary heart disease (CHD) such as insulin resistance and central obesity. We examined the association between elevated serum ALT activity and the 10-year risk of CHD as estimated using the Framingham risk score (FRS). We performed a cross-sectional analysis comparing participants in the Third National Health and Nutrition Examination Survey with normal and elevated ALT activity (>43 IU/L), examining the mean levels of FRS. Among participants without viral hepatitis or excessive alcohol consumption, those with elevated ALT activity (n = 267) had a higher FRS than those with normal ALT activity (n = 7,259), both among men (mean difference in FRS 0.25, 95% CI 0.07-0.4; hazard ratio for CHD 1.28, 95% CI 1.07-1.5) and women (mean difference in FRS 0.76, 95% CI 0.4-1.1; hazard ratio for CHD 2.14, 95% CI 1.5-3.0). The ALT threshold for increased risk of CHD was higher in men (>43 IU/L) than in women (>30 IU/L). Elevated ALT activity was not associated with higher FRS among nonobese participants with viral hepatitis or excessive alcohol consumption. In conclusion, individuals with elevated serum ALT activity in the absence of viral hepatitis or excessive alcohol consumption, most of whom have NAFLD, have an increased calculated risk of CHD. This association is more prominent in women. Copyright © 2006 by the American Association for the Study of Liver Diseases.
Persistent Identifierhttp://hdl.handle.net/10722/92507
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIoannou, GNen_HK
dc.contributor.authorWeiss, NSen_HK
dc.contributor.authorBoyko, EJen_HK
dc.contributor.authorMozaffarian, Den_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:48:21Z-
dc.date.available2010-09-17T10:48:21Z-
dc.date.issued2006en_HK
dc.identifier.citationHepatology, 2006, v. 43 n. 5, p. 1145-1151en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92507-
dc.description.abstractIn the United States, elevated serum alanine aminotransferase (ALT) activity in the absence of viral hepatitis or excessive alcohol consumption is most commonly attributed to nonalcoholic fatty liver disease (NAFLD). NAFLD is related to predictors of coronary heart disease (CHD) such as insulin resistance and central obesity. We examined the association between elevated serum ALT activity and the 10-year risk of CHD as estimated using the Framingham risk score (FRS). We performed a cross-sectional analysis comparing participants in the Third National Health and Nutrition Examination Survey with normal and elevated ALT activity (>43 IU/L), examining the mean levels of FRS. Among participants without viral hepatitis or excessive alcohol consumption, those with elevated ALT activity (n = 267) had a higher FRS than those with normal ALT activity (n = 7,259), both among men (mean difference in FRS 0.25, 95% CI 0.07-0.4; hazard ratio for CHD 1.28, 95% CI 1.07-1.5) and women (mean difference in FRS 0.76, 95% CI 0.4-1.1; hazard ratio for CHD 2.14, 95% CI 1.5-3.0). The ALT threshold for increased risk of CHD was higher in men (>43 IU/L) than in women (>30 IU/L). Elevated ALT activity was not associated with higher FRS among nonobese participants with viral hepatitis or excessive alcohol consumption. In conclusion, individuals with elevated serum ALT activity in the absence of viral hepatitis or excessive alcohol consumption, most of whom have NAFLD, have an increased calculated risk of CHD. This association is more prominent in women. Copyright © 2006 by the American Association for the Study of Liver Diseases.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleElevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United Statesen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hep.21171en_HK
dc.identifier.pmid16628637-
dc.identifier.scopuseid_2-s2.0-33646547644en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646547644&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1145en_HK
dc.identifier.epage1151en_HK
dc.identifier.isiWOS:000237327200031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridIoannou, GN=35595023000en_HK
dc.identifier.scopusauthoridWeiss, NS=35406927700en_HK
dc.identifier.scopusauthoridBoyko, EJ=7005703432en_HK
dc.identifier.scopusauthoridMozaffarian, D=6701553740en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

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