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Article: Gastric fluid bile concentrations and risk of Barrett's esophagus

TitleGastric fluid bile concentrations and risk of Barrett's esophagus
Authors
KeywordsBarrett's esophagus
Bile acids and salts
Esophageal neoplasms
Gastroesophageal reflux
Metaplasia
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://intl-icvts.ctsnetjournals.org
Citation
Interactive Cardiovascular And Thoracic Surgery, 2007, v. 6 n. 3, p. 304-307 How to Cite?
AbstractPatients with Barrett's esophagus are at high risk of progression to adenocarcinoma. A growing, but conflicting body of evidence implicates bile reflux as a contributor to Barrett's esophagus. To investigate whether duodenogastric reflux was associated with an increased risk of Barrett's esophagus, a case-control study of incident Barrett's esophagus was performed. Cases (n=72) were identified by new histologically-confirmed diagnosis of specialized intestinal metaplasia (indicative of Barrett's esophagus) following upper endoscopy for refractory gastroesophageal reflux between October 1997 and September 2000. Cases were compared to gastroesophageal reflux patients without specialized intestinal metaplasia (controls; n=72). There was no difference in total bile acid concentrations between cases and controls. Risk of Barrett's esophagus did not significantly vary with increasing concentrations of total or free bile acids, respectively (OR 0.35 (95% CI 0.12, 1.02) and 0.60 (95% CI 0.22, 1.66)). Low gastric fluid pH (toxic range 3-5), was associated with a non-significant increase in the risk of Barrett's esophagus. In conclusion, no significant association between Barrett's esophagus and total or free bile acids in gastric refluxate was found. Patients with low gastric fluid pH (3-5) may represent a subset of patients at high risk of developing Barrett's esophagus.
Persistent Identifierhttp://hdl.handle.net/10722/92506
ISSN
2015 Impact Factor: 1.329
2015 SCImago Journal Rankings: 0.743
References

 

DC FieldValueLanguage
dc.contributor.authorNason, KSen_HK
dc.contributor.authorFarrow, DCen_HK
dc.contributor.authorHaigh, Gen_HK
dc.contributor.authorLee, SPen_HK
dc.contributor.authorBronner, MPen_HK
dc.contributor.authorRosen, SNen_HK
dc.contributor.authorVaughan, TLen_HK
dc.date.accessioned2010-09-17T10:48:19Z-
dc.date.available2010-09-17T10:48:19Z-
dc.date.issued2007en_HK
dc.identifier.citationInteractive Cardiovascular And Thoracic Surgery, 2007, v. 6 n. 3, p. 304-307en_HK
dc.identifier.issn1569-9293en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92506-
dc.description.abstractPatients with Barrett's esophagus are at high risk of progression to adenocarcinoma. A growing, but conflicting body of evidence implicates bile reflux as a contributor to Barrett's esophagus. To investigate whether duodenogastric reflux was associated with an increased risk of Barrett's esophagus, a case-control study of incident Barrett's esophagus was performed. Cases (n=72) were identified by new histologically-confirmed diagnosis of specialized intestinal metaplasia (indicative of Barrett's esophagus) following upper endoscopy for refractory gastroesophageal reflux between October 1997 and September 2000. Cases were compared to gastroesophageal reflux patients without specialized intestinal metaplasia (controls; n=72). There was no difference in total bile acid concentrations between cases and controls. Risk of Barrett's esophagus did not significantly vary with increasing concentrations of total or free bile acids, respectively (OR 0.35 (95% CI 0.12, 1.02) and 0.60 (95% CI 0.22, 1.66)). Low gastric fluid pH (toxic range 3-5), was associated with a non-significant increase in the risk of Barrett's esophagus. In conclusion, no significant association between Barrett's esophagus and total or free bile acids in gastric refluxate was found. Patients with low gastric fluid pH (3-5) may represent a subset of patients at high risk of developing Barrett's esophagus.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://intl-icvts.ctsnetjournals.orgen_HK
dc.relation.ispartofInteractive Cardiovascular and Thoracic Surgeryen_HK
dc.subjectBarrett's esophagusen_HK
dc.subjectBile acids and saltsen_HK
dc.subjectEsophageal neoplasmsen_HK
dc.subjectGastroesophageal refluxen_HK
dc.subjectMetaplasiaen_HK
dc.titleGastric fluid bile concentrations and risk of Barrett's esophagusen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1510/icvts.2006.143370en_HK
dc.identifier.pmid17669852-
dc.identifier.scopuseid_2-s2.0-34249793211en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249793211&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue3en_HK
dc.identifier.spage304en_HK
dc.identifier.epage307en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridNason, KS=7801504281en_HK
dc.identifier.scopusauthoridFarrow, DC=7006613798en_HK
dc.identifier.scopusauthoridHaigh, G=16416555200en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK
dc.identifier.scopusauthoridBronner, MP=7005141992en_HK
dc.identifier.scopusauthoridRosen, SN=16417670500en_HK
dc.identifier.scopusauthoridVaughan, TL=7103008911en_HK

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