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Article: Suppression of proliferative cholangitis in a rat model by local delivery of paclitaxel

TitleSuppression of proliferative cholangitis in a rat model by local delivery of paclitaxel
Authors
KeywordsBiliary stricture
Paclitaxel
Proliferative cholangitis
Rat
Issue Date2003
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00534/index.htm
Citation
Journal Of Hepato-Biliary-Pancreatic Surgery, 2003, v. 10 n. 2, p. 176-182 How to Cite?
AbstractBackground. Proliferative cholangitis (PC) leads to biliary stricture, which is the main cause of hepatolithiasis, recurrent cholangitis, and biliary cirrhosis. The aim of this study was to determine whether local delivery of paclitaxel, which inhibits cell proliferation by overstabilization of microtubules, prevents PC in a rat model. Methods. PC was induced by introducing a fine nylon thread into the bile duct in a rat. Paclitaxel (100 μl of 10, 100, and 1000 μmol/l or solvent vehicle was administered into the bile duct for 15 min. One week after treatment, histopathologic examination and 5-bromodeoxyuridine (BrdU) labeling of the bile duct were performed. Results. In comparison with the control, the mean thickness of the bile duct was reduced by 29% in the 1000 μmol/l paclitaxel-treated group (2.61 ± 0.31 μm vs 3.67 ± 0.25 μm, P < 0.05). The luminal area increased (P < 0.0001) and the grade of epithelial-glandular proliferation was decreased (P < 0.01) as the dose of paclitaxel increased. Ductal fibrosis and inflammatory cell infiltration were similar in both groups. The BrdU labeling index was significantly lower in the paclitaxel-treated group (P < 0.05). Conclusions. Local delivery of paclitaxel suppressed PC in a rat model by the inhibition of epithelial-glandular proliferation and may offer an effective therapeutic option for biliary stricture.
Persistent Identifierhttp://hdl.handle.net/10722/92500
ISSN
2009 Impact Factor: 1.601
References

 

DC FieldValueLanguage
dc.contributor.authorPark, SMen_HK
dc.contributor.authorChoi, JWen_HK
dc.contributor.authorKim, STen_HK
dc.contributor.authorCho, MCen_HK
dc.contributor.authorSung, RHen_HK
dc.contributor.authorJang, LCen_HK
dc.contributor.authorPark, JWen_HK
dc.contributor.authorLee, SPen_HK
dc.contributor.authorPark, YHen_HK
dc.date.accessioned2010-09-17T10:48:08Z-
dc.date.available2010-09-17T10:48:08Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Hepato-Biliary-Pancreatic Surgery, 2003, v. 10 n. 2, p. 176-182en_HK
dc.identifier.issn0944-1166en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92500-
dc.description.abstractBackground. Proliferative cholangitis (PC) leads to biliary stricture, which is the main cause of hepatolithiasis, recurrent cholangitis, and biliary cirrhosis. The aim of this study was to determine whether local delivery of paclitaxel, which inhibits cell proliferation by overstabilization of microtubules, prevents PC in a rat model. Methods. PC was induced by introducing a fine nylon thread into the bile duct in a rat. Paclitaxel (100 μl of 10, 100, and 1000 μmol/l or solvent vehicle was administered into the bile duct for 15 min. One week after treatment, histopathologic examination and 5-bromodeoxyuridine (BrdU) labeling of the bile duct were performed. Results. In comparison with the control, the mean thickness of the bile duct was reduced by 29% in the 1000 μmol/l paclitaxel-treated group (2.61 ± 0.31 μm vs 3.67 ± 0.25 μm, P < 0.05). The luminal area increased (P < 0.0001) and the grade of epithelial-glandular proliferation was decreased (P < 0.01) as the dose of paclitaxel increased. Ductal fibrosis and inflammatory cell infiltration were similar in both groups. The BrdU labeling index was significantly lower in the paclitaxel-treated group (P < 0.05). Conclusions. Local delivery of paclitaxel suppressed PC in a rat model by the inhibition of epithelial-glandular proliferation and may offer an effective therapeutic option for biliary stricture.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00534/index.htmen_HK
dc.relation.ispartofJournal of Hepato-Biliary-Pancreatic Surgeryen_HK
dc.subjectBiliary strictureen_HK
dc.subjectPaclitaxelen_HK
dc.subjectProliferative cholangitisen_HK
dc.subjectRaten_HK
dc.titleSuppression of proliferative cholangitis in a rat model by local delivery of paclitaxelen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00534-002-0804-9en_HK
dc.identifier.pmid14505153-
dc.identifier.scopuseid_2-s2.0-0141813483en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141813483&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue2en_HK
dc.identifier.spage176en_HK
dc.identifier.epage182en_HK
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridPark, SM=36069939000en_HK
dc.identifier.scopusauthoridChoi, JW=24477421700en_HK
dc.identifier.scopusauthoridKim, ST=8148751100en_HK
dc.identifier.scopusauthoridCho, MC=8148751200en_HK
dc.identifier.scopusauthoridSung, RH=7101684325en_HK
dc.identifier.scopusauthoridJang, LC=8148751400en_HK
dc.identifier.scopusauthoridPark, JW=8865200100en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK
dc.identifier.scopusauthoridPark, YH=34668315300en_HK

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