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Article: Identification of oxysterols in human bile and pigment gallstones

TitleIdentification of oxysterols in human bile and pigment gallstones
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2001
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 2001, v. 121 n. 1, p. 118-123 How to Cite?
AbstractBackground & Aims: Although cholesterol is the most abundant sterol in animal tissues, oxidized products of cholesterol (oxysterols) also occur in mammalian organs and blood and are cytotoxic, atherogenic, and carcinogenic. However, the presence of oxysterols in bile or gallstones has never been reported. Methods: Fresh human bile and gallstones were collected, Sterol content and structure were analyzed using gas chromatography/mass spectrometry (GC/MS). Bacterial DNA was extracted from human gallstones. Results: GC/MS identified cholesta-4,6-diene-3-one and cholest-4-ene-3-one, with several as yet unidentified oxysterols in bile and stone samples. Several plant and fungal sterols were also present in gallstones. When 102 human gallstones were analyzed for oxysterols, they were markedly higher (as percent of total sterols) in pigment gallstones, where bacterial DNA is most abundant. Conclusions: These observations suggest biliary oxysterols are associated with the presence of bacteria and may play a role in the pathogenesis of gallstones and biliary tract cancers.
Persistent Identifierhttp://hdl.handle.net/10722/92494
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHaigh, WGeoffreyen_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:47:58Z-
dc.date.available2010-09-17T10:47:58Z-
dc.date.issued2001en_HK
dc.identifier.citationGastroenterology, 2001, v. 121 n. 1, p. 118-123en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92494-
dc.description.abstractBackground & Aims: Although cholesterol is the most abundant sterol in animal tissues, oxidized products of cholesterol (oxysterols) also occur in mammalian organs and blood and are cytotoxic, atherogenic, and carcinogenic. However, the presence of oxysterols in bile or gallstones has never been reported. Methods: Fresh human bile and gallstones were collected, Sterol content and structure were analyzed using gas chromatography/mass spectrometry (GC/MS). Bacterial DNA was extracted from human gallstones. Results: GC/MS identified cholesta-4,6-diene-3-one and cholest-4-ene-3-one, with several as yet unidentified oxysterols in bile and stone samples. Several plant and fungal sterols were also present in gallstones. When 102 human gallstones were analyzed for oxysterols, they were markedly higher (as percent of total sterols) in pigment gallstones, where bacterial DNA is most abundant. Conclusions: These observations suggest biliary oxysterols are associated with the presence of bacteria and may play a role in the pathogenesis of gallstones and biliary tract cancers.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleIdentification of oxysterols in human bile and pigment gallstonesen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11438500-
dc.identifier.scopuseid_2-s2.0-0034957745en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034957745&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume121en_HK
dc.identifier.issue1en_HK
dc.identifier.spage118en_HK
dc.identifier.epage123en_HK
dc.identifier.isiWOS:000169485600016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHaigh, WGeoffrey=6603814152en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

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