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Article: The gallbladder also secretes

TitleThe gallbladder also secretes
Authors
Keywordsepithelial transport
gallbladder
secretion
Issue Date1997
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1997, v. 42 n. 3, p. 489-491 How to Cite?
AbstractThe gallbladder is traditionally regarded as an absorptive organ. There is increasing evidence that the gallbladder mucosa can have a secretory function. We studied a patient with primary sclerosing cholangitis whose gallbladder was excluded from his extrahepatic bile ducts by stricture formation. He was admitted into hospital because of cholecystitis and cholangitis and required separate drainage tubes into his gallbladder and common hepatic duct. This unique combination of drains afforded the opportunity to examine hepatic bile and gallbladder secretion. We analyzed samples for fluid volume, protein, electrolyte concentrations and biliary lipids. The simultaneous, yet separate, drainage from the gallbladder and the liver had a striking difference. The former was colorless to opalescent; the latter always golden brown. Hepatic bile flow was continuous but gallbladder drainage was variable in volume, intermittent, and occurred only after a meal. The gallbladder fluid had no bilirubin, bile salts, cholesterol, or phospholipids and had the ionic prolife of an extracellular fluid. It was alkaline and contained abundant bicarbonate. We have shown that the gallbladder can secrete. In addition, these observations may also have important implications in the pathogenesis and prevention of gallbladder sludge and stones.
Persistent Identifierhttp://hdl.handle.net/10722/92490
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGlickerman, DJen_HK
dc.contributor.authorKim, MHen_HK
dc.contributor.authorMalik, Ren_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:47:51Z-
dc.date.available2010-09-17T10:47:51Z-
dc.date.issued1997en_HK
dc.identifier.citationDigestive Diseases And Sciences, 1997, v. 42 n. 3, p. 489-491en_HK
dc.identifier.issn0163-2116en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92490-
dc.description.abstractThe gallbladder is traditionally regarded as an absorptive organ. There is increasing evidence that the gallbladder mucosa can have a secretory function. We studied a patient with primary sclerosing cholangitis whose gallbladder was excluded from his extrahepatic bile ducts by stricture formation. He was admitted into hospital because of cholecystitis and cholangitis and required separate drainage tubes into his gallbladder and common hepatic duct. This unique combination of drains afforded the opportunity to examine hepatic bile and gallbladder secretion. We analyzed samples for fluid volume, protein, electrolyte concentrations and biliary lipids. The simultaneous, yet separate, drainage from the gallbladder and the liver had a striking difference. The former was colorless to opalescent; the latter always golden brown. Hepatic bile flow was continuous but gallbladder drainage was variable in volume, intermittent, and occurred only after a meal. The gallbladder fluid had no bilirubin, bile salts, cholesterol, or phospholipids and had the ionic prolife of an extracellular fluid. It was alkaline and contained abundant bicarbonate. We have shown that the gallbladder can secrete. In addition, these observations may also have important implications in the pathogenesis and prevention of gallbladder sludge and stones.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_HK
dc.relation.ispartofDigestive Diseases and Sciencesen_HK
dc.subjectepithelial transporten_HK
dc.subjectgallbladderen_HK
dc.subjectsecretionen_HK
dc.titleThe gallbladder also secretesen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1018826521600en_HK
dc.identifier.pmid9073128-
dc.identifier.scopuseid_2-s2.0-0030889226en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030889226&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue3en_HK
dc.identifier.spage489en_HK
dc.identifier.epage491en_HK
dc.identifier.isiWOS:A1997WP03100003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGlickerman, DJ=6602668133en_HK
dc.identifier.scopusauthoridKim, MH=35272034400en_HK
dc.identifier.scopusauthoridMalik, R=7201876476en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

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