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Article: Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits

TitleAspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits
Authors
KeywordsAspirin
Cytoprotection
Glycoprotein
Ileal conduit
Mucin
NSAID
Secretion
Issue Date1996
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0282-0080
Citation
Glycoconjugate Journal, 1996, v. 13 n. 5, p. 781-789 How to Cite?
AbstractThe effect of aspirin on the rate of secretion and amino acid composition of human ileal mucin was studied, using subjects with ileal conduits as a model system in which mucin secreted from the ileal conduit tissue is flushed out in the urine and can be measured and analysed. Aspirin (600 mg per day, administered orally) increased the daily mucin output by 37-104% in subjects by days 3 or 4, but thereafter the mucin output declined to below the baseline level by day 10. Mucin samples, purified from the ileal conduit urine during the control period and during aspirin administration, were compared. There were no discernible changes in the degree of polymerisation or the density, bu during aspirin administration the amino acid composition was significantly changed, and in particular threonine and proline were enriched. One possible explanation, consistent with the compositional analyses, is that the N- and C-terminal regions of the mucin subunits have been cleaved off and lost during aspirin administration. The observed changes in mucin secretion may have implications for the mechanism of the toxic effects of aspirin on the small intestine by altering the barrier properties of the mucus layer.
Persistent Identifierhttp://hdl.handle.net/10722/92488
ISSN
2015 Impact Factor: 1.828
2015 SCImago Journal Rankings: 0.747
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRoberton, AMen_HK
dc.contributor.authorRabel, Ben_HK
dc.contributor.authorStubbs, Len_HK
dc.contributor.authorTasmanJones, Cen_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:47:47Z-
dc.date.available2010-09-17T10:47:47Z-
dc.date.issued1996en_HK
dc.identifier.citationGlycoconjugate Journal, 1996, v. 13 n. 5, p. 781-789en_HK
dc.identifier.issn0282-0080en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92488-
dc.description.abstractThe effect of aspirin on the rate of secretion and amino acid composition of human ileal mucin was studied, using subjects with ileal conduits as a model system in which mucin secreted from the ileal conduit tissue is flushed out in the urine and can be measured and analysed. Aspirin (600 mg per day, administered orally) increased the daily mucin output by 37-104% in subjects by days 3 or 4, but thereafter the mucin output declined to below the baseline level by day 10. Mucin samples, purified from the ileal conduit urine during the control period and during aspirin administration, were compared. There were no discernible changes in the degree of polymerisation or the density, bu during aspirin administration the amino acid composition was significantly changed, and in particular threonine and proline were enriched. One possible explanation, consistent with the compositional analyses, is that the N- and C-terminal regions of the mucin subunits have been cleaved off and lost during aspirin administration. The observed changes in mucin secretion may have implications for the mechanism of the toxic effects of aspirin on the small intestine by altering the barrier properties of the mucus layer.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0282-0080en_HK
dc.relation.ispartofGlycoconjugate Journalen_HK
dc.subjectAspirinen_HK
dc.subjectCytoprotectionen_HK
dc.subjectGlycoproteinen_HK
dc.subjectIleal conduiten_HK
dc.subjectMucinen_HK
dc.subjectNSAIDen_HK
dc.subjectSecretionen_HK
dc.titleAspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduitsen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF00702342en_HK
dc.identifier.pmid8910005-
dc.identifier.scopuseid_2-s2.0-0029827862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029827862&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue5en_HK
dc.identifier.spage781en_HK
dc.identifier.epage789en_HK
dc.identifier.isiWOS:A1996VP19400011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRoberton, AM=7003310534en_HK
dc.identifier.scopusauthoridRabel, B=16158653200en_HK
dc.identifier.scopusauthoridStubbs, L=7006540189en_HK
dc.identifier.scopusauthoridTasmanJones, C=7003303326en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

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