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Article: The production of oxysterols in bile by activated human leukocytes

TitleThe production of oxysterols in bile by activated human leukocytes
Authors
KeywordsBile
Cholangiocarcinoma
Cholesterol oxides
Gallbladder cancer
Infection
Leukocytes
Lipopolysaccharide
Oxysterols
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2006, v. 343 n. 2, p. 467-469 How to Cite?
AbstractOxysterols are naturally occurring intermediates in the conversion of cholesterol to bile acids, the major route for elimination of cholesterol. Additionally, they are important signaling agents, particularly in control of cholesterol synthesis; however, some species also are cytotoxic and carcinogenic. Oxysterols in plasma, contained in oxidized low-density lipoprotein, are strongly correlated with atherosclerosis. Oxysterols are found in infected human bile and the oxysterol content in gallstones correlates with bacterial DNA in the stones. Here we demonstrate that human leukocytes, activated by the presence of bacterial lipopolysaccharide, are able to oxidize cholesterol to a variety of oxysterols, including species known to be carcinogenic.
Persistent Identifierhttp://hdl.handle.net/10722/92485
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHaigh, WGen_HK
dc.contributor.authorWong, Ten_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:47:42Z-
dc.date.available2010-09-17T10:47:42Z-
dc.date.issued2006en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2006, v. 343 n. 2, p. 467-469en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/92485-
dc.description.abstractOxysterols are naturally occurring intermediates in the conversion of cholesterol to bile acids, the major route for elimination of cholesterol. Additionally, they are important signaling agents, particularly in control of cholesterol synthesis; however, some species also are cytotoxic and carcinogenic. Oxysterols in plasma, contained in oxidized low-density lipoprotein, are strongly correlated with atherosclerosis. Oxysterols are found in infected human bile and the oxysterol content in gallstones correlates with bacterial DNA in the stones. Here we demonstrate that human leukocytes, activated by the presence of bacterial lipopolysaccharide, are able to oxidize cholesterol to a variety of oxysterols, including species known to be carcinogenic.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectBileen_HK
dc.subjectCholangiocarcinomaen_HK
dc.subjectCholesterol oxidesen_HK
dc.subjectGallbladder canceren_HK
dc.subjectInfectionen_HK
dc.subjectLeukocytesen_HK
dc.subjectLipopolysaccharideen_HK
dc.subjectOxysterolsen_HK
dc.titleThe production of oxysterols in bile by activated human leukocytesen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2006.02.165en_HK
dc.identifier.pmid16546125-
dc.identifier.pmcidPMC2628770-
dc.identifier.scopuseid_2-s2.0-33645116730en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645116730&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume343en_HK
dc.identifier.issue2en_HK
dc.identifier.spage467en_HK
dc.identifier.epage469en_HK
dc.identifier.eissn1090-2104-
dc.identifier.isiWOS:000236659800017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHaigh, WG=6603814152en_HK
dc.identifier.scopusauthoridWong, T=36839499900en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

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