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Article: Apolipoprotein E genotype and the risk of gallbladder disease in pregnancy

TitleApolipoprotein E genotype and the risk of gallbladder disease in pregnancy
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 2000, v. 31 n. 1, p. 18-23 How to Cite?
AbstractThe E4 allele of apolipoprotein E (apoE4) has previously been associated with symptomatic gallstone disease. The aim of this study was to determine if apoE4 is associated with the development of gallbladder sludge and/or stones during pregnancy. We conducted a nested case-control study based on an ongoing cohort study of gallbladder disease in pregnancy. Women in this study receive gallbladder ultrasounds in each trimester of pregnancy. Cases (n = 52) were defined as women with incident gallbladder sludge or stones diagnosed at the third trimester ultrasound. Controls (n = 104) were defined as women without gallbladder sludge or stones on any of 3 study ultrasounds. ApoE genotyping was performed from stored white blood cell pellets. Data were analyzed by stratified analysis and multivariate logistic regression. Cases and controls were similar in baseline characteristics. Forty-two women had sludge, 6 had gallstones, and 4 had both sludge and stones. After adjusting for risk factors such as age, parity, and body mass index, the odds ratio (OR) for the association between heterozygosity or homozygosity for the apoE4 allele and incident gallbladder sludge or stones was 0.91 (95% confidence interval [CI], 0.41-2.02). Further adjustment for family medical history and serum lipid levels did not substantially change these results (OR, 0.73; 95% CI, 0.29-1.82). In conclusion, apoE4 appears to have little or no overall association with the development of new gallbladder sludge or stones in pregnancy. However, an effect could not be ruled out in certain subgroups, such as blacks or women who are homozygous for apoE4.
Persistent Identifierhttp://hdl.handle.net/10722/92483
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCynthia, WKOen_HK
dc.contributor.authorBeresford, SAAen_HK
dc.contributor.authorAlderman, Ben_HK
dc.contributor.authorJarvik, GPen_HK
dc.contributor.authorSchulte, SJen_HK
dc.contributor.authorCalhoun, Ben_HK
dc.contributor.authorTsuchida, AMen_HK
dc.contributor.authorKoepsell, TDen_HK
dc.contributor.authorLee, SPen_HK
dc.date.accessioned2010-09-17T10:47:38Z-
dc.date.available2010-09-17T10:47:38Z-
dc.date.issued2000en_HK
dc.identifier.citationHepatology, 2000, v. 31 n. 1, p. 18-23en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92483-
dc.description.abstractThe E4 allele of apolipoprotein E (apoE4) has previously been associated with symptomatic gallstone disease. The aim of this study was to determine if apoE4 is associated with the development of gallbladder sludge and/or stones during pregnancy. We conducted a nested case-control study based on an ongoing cohort study of gallbladder disease in pregnancy. Women in this study receive gallbladder ultrasounds in each trimester of pregnancy. Cases (n = 52) were defined as women with incident gallbladder sludge or stones diagnosed at the third trimester ultrasound. Controls (n = 104) were defined as women without gallbladder sludge or stones on any of 3 study ultrasounds. ApoE genotyping was performed from stored white blood cell pellets. Data were analyzed by stratified analysis and multivariate logistic regression. Cases and controls were similar in baseline characteristics. Forty-two women had sludge, 6 had gallstones, and 4 had both sludge and stones. After adjusting for risk factors such as age, parity, and body mass index, the odds ratio (OR) for the association between heterozygosity or homozygosity for the apoE4 allele and incident gallbladder sludge or stones was 0.91 (95% confidence interval [CI], 0.41-2.02). Further adjustment for family medical history and serum lipid levels did not substantially change these results (OR, 0.73; 95% CI, 0.29-1.82). In conclusion, apoE4 appears to have little or no overall association with the development of new gallbladder sludge or stones in pregnancy. However, an effect could not be ruled out in certain subgroups, such as blacks or women who are homozygous for apoE4.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleApolipoprotein E genotype and the risk of gallbladder disease in pregnancyen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SP: sumlee@hku.hken_HK
dc.identifier.authorityLee, SP=rp01351en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10613722-
dc.identifier.scopuseid_2-s2.0-17544370214en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17544370214&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue1en_HK
dc.identifier.spage18en_HK
dc.identifier.epage23en_HK
dc.identifier.isiWOS:000084550700005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCynthia, WKO=21645102100en_HK
dc.identifier.scopusauthoridBeresford, SAA=7006403537en_HK
dc.identifier.scopusauthoridAlderman, B=7006263454en_HK
dc.identifier.scopusauthoridJarvik, GP=35371051800en_HK
dc.identifier.scopusauthoridSchulte, SJ=7006502482en_HK
dc.identifier.scopusauthoridCalhoun, B=35515688400en_HK
dc.identifier.scopusauthoridTsuchida, AM=7101698432en_HK
dc.identifier.scopusauthoridKoepsell, TD=35354432500en_HK
dc.identifier.scopusauthoridLee, SP=7601417497en_HK

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