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Article: Abnormal grey matter in victims of rape with PTSD in Mainland China: A voxel-based morphometry study

TitleAbnormal grey matter in victims of rape with PTSD in Mainland China: A voxel-based morphometry study
Authors
KeywordsChina
Mri
Post-Traumatic Stress Disorder
Rape
Voxel-Based Morphometry
Issue Date2010
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACN
Citation
Acta Neuropsychiatrica, 2010, v. 22 n. 3, p. 118-126 How to Cite?
AbstractObjective: This study examined changes in brain grey matter in victims of rape (VoR) with and without post-traumatic stress disorder (PTSD). Previous research has focused on PTSD caused by various traumatic events, such as war and disaster, among others. Although considerable research has focused on rape-related PTSD, limited studies have been carried out in the context of Mainland China. Methods: The study included 11 VoR with PTSD, 8 VoR without PTSD and 12 healthy comparison (HC) subjects. We used voxel-based morphometry to explore changes in brain grey-matter density (GMD) by applying statistical parametric mapping to high-resolution magnetic resonance images. Results: Compared with HC, VoR with PTSD showed significant GMD reductions in the bilateral medial frontal cortex, left middle frontal cortex, middle temporal gyrus and fusiform cortex and significant GMD increases in the right posterior cingulate cortex, postcentral cortex, bilateral precentral cortex and inferior parietal lobule. Compared to VoR without PTSD, VoR with PTSD showed significant GMD reductions in the right uncus, left middle temporal gyrus, and the fusiform cortex, and increases in the left precentral cortex, inferior parietal lobule and right post-central cortex. Conclusion: The findings of abnormal GMD in VoR with PTSD support the hypothesis that PTSD is associated with widespread anatomical changes in the brain. The medial frontal cortex, precentral cortex, posterior cingulate cortex, post-central cortex and inferior parietal lobule may play important roles in the neuropathology of PTSD. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/92414
ISSN
2012 Impact Factor: 0.606
2015 SCImago Journal Rankings: 0.421
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30830046
National Science and Technology Program of China2007 BAI17B02
National 973 Program of China2009CB918303
2006CB5000800
Program of Chinese Ministry of Education20090162110011
Funding Information:

We acknowledgement support from grant from the National Natural Science Foundation of China (30830046 to Lingjiang Li and Shuangge Sui), the National Science and Technology Program of China (2007 BAI17B02 to Lingjiang Li and Shuangge Sui), the National 973 Program of China (2009CB918303, 2006CB5000800 to Lingjiang Li); Program of Chinese Ministry of Education (20090162110011 to Lingjiang Li).

References

 

DC FieldValueLanguage
dc.contributor.authorSui, SGen_HK
dc.contributor.authorWu, MXen_HK
dc.contributor.authorKing, MEen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorLing, Len_HK
dc.contributor.authorXu, JMen_HK
dc.contributor.authorWeng, XCen_HK
dc.contributor.authorDuan, Len_HK
dc.contributor.authorShan, BCen_HK
dc.contributor.authorLi, LJen_HK
dc.date.accessioned2010-09-17T10:45:26Z-
dc.date.available2010-09-17T10:45:26Z-
dc.date.issued2010en_HK
dc.identifier.citationActa Neuropsychiatrica, 2010, v. 22 n. 3, p. 118-126en_HK
dc.identifier.issn0924-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92414-
dc.description.abstractObjective: This study examined changes in brain grey matter in victims of rape (VoR) with and without post-traumatic stress disorder (PTSD). Previous research has focused on PTSD caused by various traumatic events, such as war and disaster, among others. Although considerable research has focused on rape-related PTSD, limited studies have been carried out in the context of Mainland China. Methods: The study included 11 VoR with PTSD, 8 VoR without PTSD and 12 healthy comparison (HC) subjects. We used voxel-based morphometry to explore changes in brain grey-matter density (GMD) by applying statistical parametric mapping to high-resolution magnetic resonance images. Results: Compared with HC, VoR with PTSD showed significant GMD reductions in the bilateral medial frontal cortex, left middle frontal cortex, middle temporal gyrus and fusiform cortex and significant GMD increases in the right posterior cingulate cortex, postcentral cortex, bilateral precentral cortex and inferior parietal lobule. Compared to VoR without PTSD, VoR with PTSD showed significant GMD reductions in the right uncus, left middle temporal gyrus, and the fusiform cortex, and increases in the left precentral cortex, inferior parietal lobule and right post-central cortex. Conclusion: The findings of abnormal GMD in VoR with PTSD support the hypothesis that PTSD is associated with widespread anatomical changes in the brain. The medial frontal cortex, precentral cortex, posterior cingulate cortex, post-central cortex and inferior parietal lobule may play important roles in the neuropathology of PTSD. © 2010 John Wiley & Sons A/S.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACNen_HK
dc.relation.ispartofActa Neuropsychiatricaen_HK
dc.subjectChinaen_HK
dc.subjectMrien_HK
dc.subjectPost-Traumatic Stress Disorderen_HK
dc.subjectRapeen_HK
dc.subjectVoxel-Based Morphometryen_HK
dc.titleAbnormal grey matter in victims of rape with PTSD in Mainland China: A voxel-based morphometry studyen_HK
dc.typeArticleen_HK
dc.identifier.emailKing, ME:mark.king@hkusua.hku.hken_HK
dc.identifier.authorityKing, ME=rp1341en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1601-5215.2010.00459.xen_HK
dc.identifier.scopuseid_2-s2.0-77951949351en_HK
dc.identifier.hkuros182317-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951949351&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue3en_HK
dc.identifier.spage118en_HK
dc.identifier.epage126en_HK
dc.identifier.eissn1601-5215-
dc.identifier.isiWOS:000277319500003-
dc.identifier.citeulike7281373-

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