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Article: Sensitivity and specificity of Epstein-Barr virus IgA titer in the diagnosis of nasopharyngeal carcinoma: A three-year institutional review

TitleSensitivity and specificity of Epstein-Barr virus IgA titer in the diagnosis of nasopharyngeal carcinoma: A three-year institutional review
Authors
KeywordsEBV
EBV IgA
Nasopharyngeal carcinoma
Nasopharyngeal carcinoma screening
Sensitivity
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2004, v. 26 n. 7, p. 598-602 How to Cite?
AbstractBackground. IgA antibody titers to the Epstein-Barr virus (EBV) viral capsid antigen (EBV IgA-VCA) and to the EBV early antigen (EBV IgA-EA) are used to screen for nasopharyngeal carcinoma (NPC). This study evaluates the sensitivity and specificity of EBV IgA-VCA and EBV IgA-EA titers in screening patients for NPC and in those diagnosed with NPC at our institution. Methods. NPC status was determined for all patients who had their EBV IgA-VCA and EBV-IgA EA titers measured over a 3-year period, and the sensitivity and specificity were calculated. Results. Five thousand one hundred ninety-six samples were analyzed. NPC was diagnosed in 215 patients. The sensitivity and specificity of a raised EBV IgA-VCA titer (≥1:5) for diagnosing NPC were 89% and 80%, respectively, with a raised EbV IgA-EA titer (≥1:5) having a sensitivity and specificity of 63% and 97%, respectively. Conclusions. Although the EBV IgA-VCA titer is sensitive for the diagnosis of NPC, it should not be used as the sole means of screening for NPC in a population in which NPC is endemic. © 2004 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/92381
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorVlantis, ACen_HK
dc.contributor.authorHo, FWKen_HK
dc.contributor.authorTam, JSLen_HK
dc.contributor.authorTo, KFen_HK
dc.contributor.authorVan Hasselt, CAen_HK
dc.date.accessioned2010-09-17T10:44:23Z-
dc.date.available2010-09-17T10:44:23Z-
dc.date.issued2004en_HK
dc.identifier.citationHead And Neck, 2004, v. 26 n. 7, p. 598-602en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92381-
dc.description.abstractBackground. IgA antibody titers to the Epstein-Barr virus (EBV) viral capsid antigen (EBV IgA-VCA) and to the EBV early antigen (EBV IgA-EA) are used to screen for nasopharyngeal carcinoma (NPC). This study evaluates the sensitivity and specificity of EBV IgA-VCA and EBV IgA-EA titers in screening patients for NPC and in those diagnosed with NPC at our institution. Methods. NPC status was determined for all patients who had their EBV IgA-VCA and EBV-IgA EA titers measured over a 3-year period, and the sensitivity and specificity were calculated. Results. Five thousand one hundred ninety-six samples were analyzed. NPC was diagnosed in 215 patients. The sensitivity and specificity of a raised EBV IgA-VCA titer (≥1:5) for diagnosing NPC were 89% and 80%, respectively, with a raised EbV IgA-EA titer (≥1:5) having a sensitivity and specificity of 63% and 97%, respectively. Conclusions. Although the EBV IgA-VCA titer is sensitive for the diagnosis of NPC, it should not be used as the sole means of screening for NPC in a population in which NPC is endemic. © 2004 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectEBVen_HK
dc.subjectEBV IgAen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectNasopharyngeal carcinoma screeningen_HK
dc.subjectSensitivityen_HK
dc.titleSensitivity and specificity of Epstein-Barr virus IgA titer in the diagnosis of nasopharyngeal carcinoma: A three-year institutional reviewen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.20022en_HK
dc.identifier.pmid15229902-
dc.identifier.scopuseid_2-s2.0-3042826423en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042826423&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue7en_HK
dc.identifier.spage598en_HK
dc.identifier.epage602en_HK
dc.identifier.isiWOS:000222322700005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridVlantis, AC=35585515400en_HK
dc.identifier.scopusauthoridHo, FWK=7103408220en_HK
dc.identifier.scopusauthoridTam, JSL=24788939600en_HK
dc.identifier.scopusauthoridTo, KF=7101911940en_HK
dc.identifier.scopusauthoridVan Hasselt, CA=7103394173en_HK

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