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Article: Topical delivery of silver nanoparticles promotes wound healing

TitleTopical delivery of silver nanoparticles promotes wound healing
Authors
KeywordsCytokines
Medicinal chemistry
Nanostructures
Proteomics
Silver
Wound healing
Issue Date2007
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
Citation
Chemmedchem, 2007, v. 2 n. 1, p. 129-136 How to Cite?
AbstractWound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/92366
ISSN
2015 Impact Factor: 2.98
2015 SCImago Journal Rankings: 1.183
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTian, Jen_HK
dc.contributor.authorWong, KKYen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorLok, CNen_HK
dc.contributor.authorYu, WYen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorChiu, JFen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-17T10:43:56Z-
dc.date.available2010-09-17T10:43:56Z-
dc.date.issued2007en_HK
dc.identifier.citationChemmedchem, 2007, v. 2 n. 1, p. 129-136en_HK
dc.identifier.issn1860-7179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92366-
dc.description.abstractWound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305en_HK
dc.relation.ispartofChemMedChemen_HK
dc.subjectCytokinesen_HK
dc.subjectMedicinal chemistryen_HK
dc.subjectNanostructuresen_HK
dc.subjectProteomicsen_HK
dc.subjectSilveren_HK
dc.subjectWound healingen_HK
dc.titleTopical delivery of silver nanoparticles promotes wound healingen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, KKY: kkywong@hku.hken_HK
dc.identifier.emailHo, CM: rickyho@hkucc.hku.hken_HK
dc.identifier.emailLok, CN: cnlok@hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.identifier.authorityHo, CM=rp00705en_HK
dc.identifier.authorityLok, CN=rp00752en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cmdc.200600171en_HK
dc.identifier.pmid17075952-
dc.identifier.scopuseid_2-s2.0-34247598245en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247598245&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue1en_HK
dc.identifier.spage129en_HK
dc.identifier.epage136en_HK
dc.identifier.eissn1860-7187-
dc.identifier.isiWOS:000202946600013-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridTian, J=55244111400en_HK
dc.identifier.scopusauthoridWong, KKY=24438686400en_HK
dc.identifier.scopusauthoridHo, CM=12807243800en_HK
dc.identifier.scopusauthoridLok, CN=7006410829en_HK
dc.identifier.scopusauthoridYu, WY=7403913673en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridChiu, JF=7201501692en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.citeulike6748835-

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