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Article: Fluorescent polystyrene-Fe3O4 composite nanospheres for in vivo imaging and hyperthermia

TitleFluorescent polystyrene-Fe3O4 composite nanospheres for in vivo imaging and hyperthermia
Authors
KeywordsAmines
Fluorescence
Polyethylene Glycols
Polystyrenes
Superparamagnetism
Zinc Sulfide
Issue Date2009
PublisherWiley - V C H Verlag GmbH & Co KGaA
Citation
Advanced Materials, 2009, v. 21 n. 21, p. 2170-2173 How to Cite?
AbstractQuantum dots (QD) were immobilized on the surface of a superparamagnetic composite of polyethylene-oxide-modified PS NSs. These QDs have a CdSeTe core and a ZnS shell with a covalently attached, amine-functionalized layer of PEG. About 200μL of a freshly prepared solution of 30 mg NHS and 10 mg EDC of PBS was mixed with 100μL of a suspension containing 2 mg of MNS and 160 pmol of QDs. The reaction mixture was incubated for 12 h at 50°C, cooled to room temperature, and centrifuged at 12 000 rpm for 5 minutes. A drop of QD-NS suspension was smeared on a glass slide for microscopic evaluation using an Olympus BX51 equipped with a fluorescence illumination module. The QD-MNS nanoparticles are clearly visible as individual spherical units spread across the slide. Each particle exhibits intense red-light emission against the dark background, suggesting effective immobilization of QDs on the surfaces of PS-MNS.
Persistent Identifierhttp://hdl.handle.net/10722/92318
ISSN
2015 Impact Factor: 18.96
2015 SCImago Journal Rankings: 9.021
ISI Accession Number ID
Funding AgencyGrant Number
NSF NIRTEAR-0403732
Funding Information:

The work performed at University of Cincinnati (UC) was supported by a grant from the UC Institute for Nanoscale Science and Technology. The TEM analyses were conducted at the Electron Microbeam Analysis Laboratory at the University of Michigan and supported by an NSF NIRT grant (EAR-0403732). Supporting Information is available online from Wiley InterScience or from the author.

References

 

DC FieldValueLanguage
dc.contributor.authorShi, Den_HK
dc.contributor.authorCho, HSen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorGu, Hen_HK
dc.contributor.authorLian, Jen_HK
dc.contributor.authorWang, Wen_HK
dc.contributor.authorLiu, Gen_HK
dc.contributor.authorHuth, Cen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorEwing, RCen_HK
dc.contributor.authorBudko, Sen_HK
dc.contributor.authorPauletti, GMen_HK
dc.contributor.authorDong, Zen_HK
dc.date.accessioned2010-09-17T10:42:30Z-
dc.date.available2010-09-17T10:42:30Z-
dc.date.issued2009en_HK
dc.identifier.citationAdvanced Materials, 2009, v. 21 n. 21, p. 2170-2173en_HK
dc.identifier.issn0935-9648en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92318-
dc.description.abstractQuantum dots (QD) were immobilized on the surface of a superparamagnetic composite of polyethylene-oxide-modified PS NSs. These QDs have a CdSeTe core and a ZnS shell with a covalently attached, amine-functionalized layer of PEG. About 200μL of a freshly prepared solution of 30 mg NHS and 10 mg EDC of PBS was mixed with 100μL of a suspension containing 2 mg of MNS and 160 pmol of QDs. The reaction mixture was incubated for 12 h at 50°C, cooled to room temperature, and centrifuged at 12 000 rpm for 5 minutes. A drop of QD-NS suspension was smeared on a glass slide for microscopic evaluation using an Olympus BX51 equipped with a fluorescence illumination module. The QD-MNS nanoparticles are clearly visible as individual spherical units spread across the slide. Each particle exhibits intense red-light emission against the dark background, suggesting effective immobilization of QDs on the surfaces of PS-MNS.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaAen_HK
dc.relation.ispartofAdvanced Materialsen_HK
dc.subjectAminesen_HK
dc.subjectFluorescenceen_HK
dc.subjectPolyethylene Glycolsen_HK
dc.subjectPolystyrenesen_HK
dc.subjectSuperparamagnetismen_HK
dc.subjectZinc Sulfideen_HK
dc.titleFluorescent polystyrene-Fe3O4 composite nanospheres for in vivo imaging and hyperthermiaen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adma.200803159en_HK
dc.identifier.scopuseid_2-s2.0-67649283326en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649283326&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue21en_HK
dc.identifier.spage2170en_HK
dc.identifier.epage2173en_HK
dc.identifier.isiWOS:000267308800006-

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