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Article: Risk factors and infection characteristics of secondary pancreatic infection in severe acute pancreatitis

TitleRisk factors and infection characteristics of secondary pancreatic infection in severe acute pancreatitis
Authors
KeywordsHe, F.Q.
Department Of Integrated Traditional Chinese And Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China., © Medline® Is The Source For The Citation And Abstract Of This Record.
Issue Date2008
Citation
Zhonghua wai ke za zhi [Chinese journal of surgery], 2008, v. 46 n. 4, p. 283-285 How to Cite?
AbstractOBJECTIVE: To explore risk factors and infection characteristics of secondary pancreatic infection in severe acute pancreatitis (SAP). METHODS: A clinical data of 49 patients with secondary pancreatic infection in severe acute pancreatitis (SPI group)were matched with 49 patients without infection in severe acute pancreatitis (NSPI group) between January 2003 and December 2005. The two groups were analyzed by a case-control study. Conditional Logistic regression model univariate and multivariate were used to screen out risk factors. The types of infection, the peak infection and the bacteria spectrum were analyzed in SPI group. RESULTS: (1) In univariate Logistic regression analysis, 7 factors including continuous hypoalbuminemia, prolonged time of central venous catheter, usage of hormone, high APACHE II scores, multi-antibiotics, intestine dysfunction and continuous hyperglycemia were selected out. Moreover, the first three were statistically significant in multivariate Logistic regression analysis. (2) Pancreatic abscess ranked first in SPI group. Of all the pancreatic infection, 22.5% occurred within two weeks and 71.4% occurred in the 4th week or later. (3) In SPI group, 81 strains of microorganisms were cultured, including 45 strains of gram-negative bacteria (55.6%), 22 strains of gram-positive bacteria (27.2%), and 14 strains of fungi (17.3%). The common gram-negative bacteria were Escherichia coli, and the common gram-positive bacteria were Staphylococci and Enterococci. The fungi included Monilia and Yeastoid fungus. Further study revealed that 35 strains of all the microorganisms were intestinal bacteria (43.2%). CONCLUSIONS: Continuous hypoalbuminemia, prolonged time of central venous catheter and usage of hormone were independent risk factors of SPI. The main type of infection was pancreatic abscess. Gram-negative bacteria, were the common bacteria causing secondary pancreatic infection.
Persistent Identifierhttp://hdl.handle.net/10722/92294
ISSN
2015 SCImago Journal Rankings: 0.133

 

DC FieldValueLanguage
dc.contributor.authorHe, FQen_HK
dc.contributor.authorHuang, ZWen_HK
dc.contributor.authorGuo, Jen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorFan, JYen_HK
dc.contributor.authorLi, YHen_HK
dc.date.accessioned2010-09-17T10:41:48Z-
dc.date.available2010-09-17T10:41:48Z-
dc.date.issued2008en_HK
dc.identifier.citationZhonghua wai ke za zhi [Chinese journal of surgery], 2008, v. 46 n. 4, p. 283-285en_HK
dc.identifier.issn0529-5815en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92294-
dc.description.abstractOBJECTIVE: To explore risk factors and infection characteristics of secondary pancreatic infection in severe acute pancreatitis (SAP). METHODS: A clinical data of 49 patients with secondary pancreatic infection in severe acute pancreatitis (SPI group)were matched with 49 patients without infection in severe acute pancreatitis (NSPI group) between January 2003 and December 2005. The two groups were analyzed by a case-control study. Conditional Logistic regression model univariate and multivariate were used to screen out risk factors. The types of infection, the peak infection and the bacteria spectrum were analyzed in SPI group. RESULTS: (1) In univariate Logistic regression analysis, 7 factors including continuous hypoalbuminemia, prolonged time of central venous catheter, usage of hormone, high APACHE II scores, multi-antibiotics, intestine dysfunction and continuous hyperglycemia were selected out. Moreover, the first three were statistically significant in multivariate Logistic regression analysis. (2) Pancreatic abscess ranked first in SPI group. Of all the pancreatic infection, 22.5% occurred within two weeks and 71.4% occurred in the 4th week or later. (3) In SPI group, 81 strains of microorganisms were cultured, including 45 strains of gram-negative bacteria (55.6%), 22 strains of gram-positive bacteria (27.2%), and 14 strains of fungi (17.3%). The common gram-negative bacteria were Escherichia coli, and the common gram-positive bacteria were Staphylococci and Enterococci. The fungi included Monilia and Yeastoid fungus. Further study revealed that 35 strains of all the microorganisms were intestinal bacteria (43.2%). CONCLUSIONS: Continuous hypoalbuminemia, prolonged time of central venous catheter and usage of hormone were independent risk factors of SPI. The main type of infection was pancreatic abscess. Gram-negative bacteria, were the common bacteria causing secondary pancreatic infection.en_HK
dc.languageengen_HK
dc.relation.ispartofZhonghua wai ke za zhi [Chinese journal of surgery]en_HK
dc.subjectHe, F.Q.en_HK
dc.subjectDepartment Of Integrated Traditional Chinese And Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China., © Medline® Is The Source For The Citation And Abstract Of This Record.en_HK
dc.titleRisk factors and infection characteristics of secondary pancreatic infection in severe acute pancreatitisen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid18683766-
dc.identifier.scopuseid_2-s2.0-64849094627en_HK
dc.identifier.volume46en_HK
dc.identifier.issue4en_HK
dc.identifier.spage283en_HK
dc.identifier.epage285en_HK

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