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Article: Aidi Injection as an adjunct therapy for non-small cell lung cancer: A systematic review

TitleAidi Injection as an adjunct therapy for non-small cell lung cancer: A systematic review
Authors
KeywordsAidi Injection
Non-Small Cell Lung Cancer
Randomized Controlled Trials
Systematic Review
Issue Date2009
Citation
Journal of Chinese Integrative Medicine, 2009, v. 7 n. 4, p. 315-324 How to Cite?
AbstractObjective: To assess methodological quality of clinical studies using Aidi Injection as an adjunct therapy for non-small cell lung cancer (NSCLC) and to evaluate the effects of Aidi Injection. Methods: PubMed (1980-2008), Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2008), EMBASE (1984-2008), CancerLit (1996-2003), CBMdisc (1980-2008), CNKI database (1980-2008), Wanfang database (1980-2008), and Chongqing VIP database (1980-2008) were searched. The authors also hand-searched Chinese periodicals potentially related to the question. All randomized controlled trials comparing Aidi Injection with other treatment methods of NSCLC were included. Two reviewers selected studies, assessed the quality of studies, and extracted the data independently. The included studies were appraised and analyzed by Cochrane Collaboration Review Manager 5.0. Results: Fourteen randomized controlled trials were included in the meta-analysis, but the quality of reports of the 14 included studies was poor. Aidi Injection combined with cobalt-60 or navelbine and platinol (NP) showed statistically significant differences in improving the response rate as compared with single use of cobalt-60 (P = 0.000 2) or NP (P = 0.04), and the relative risk (RR) and 95% confidence interval (CI) were 1.93[1.36, 2.72] and 1.18[1.00, 1.38], respectively. However, Aidi Injection combined with etoposide and platinol (EP), taxinol and platinol (TP) or gamma knife showed no significant differences as compared with single use of EP (P = 0.60), TP (P = 0.16) or gamma knife (P = 0.34), respectively. The RR and 95% CI of EP, TP and gamma knife were 1. 17[0.65, 2.09], 1.27[0.91, 1.78] and 1.08 [0.92, 1.26] respectively. Six studies indicated that Aidi Injection combined with NP or gamma knife could improve the quality of life. Six studies showed that Aidi Injection combined with NP or TP could improve the bone marrow hematopoietic function. Three studies indicated that Aidi Injection combined with NP could improve the immune function. Three studies showed that the combined therapy could not improve 1-, 2-, and 3-year survival rates. Conclusion: The results of meta-analysis indicate that Aidi Injection may have adjuvant therapeutic effects in treatment of NSCLC patients, but the sample size is too small and with poor quality, and the existence of publication bias is found. The effects of Aidi Injection need to be confirmed by large multicenter randomized controlled trials.
Persistent Identifierhttp://hdl.handle.net/10722/92265
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorMa, W-Hen_HK
dc.contributor.authorDuan, K-Nen_HK
dc.contributor.authorFeng, Men_HK
dc.contributor.authorShe, Ben_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorZhang, R-Men_HK
dc.date.accessioned2010-09-17T10:40:56Z-
dc.date.available2010-09-17T10:40:56Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal of Chinese Integrative Medicine, 2009, v. 7 n. 4, p. 315-324en_HK
dc.identifier.issn1672-1977en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92265-
dc.description.abstractObjective: To assess methodological quality of clinical studies using Aidi Injection as an adjunct therapy for non-small cell lung cancer (NSCLC) and to evaluate the effects of Aidi Injection. Methods: PubMed (1980-2008), Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2008), EMBASE (1984-2008), CancerLit (1996-2003), CBMdisc (1980-2008), CNKI database (1980-2008), Wanfang database (1980-2008), and Chongqing VIP database (1980-2008) were searched. The authors also hand-searched Chinese periodicals potentially related to the question. All randomized controlled trials comparing Aidi Injection with other treatment methods of NSCLC were included. Two reviewers selected studies, assessed the quality of studies, and extracted the data independently. The included studies were appraised and analyzed by Cochrane Collaboration Review Manager 5.0. Results: Fourteen randomized controlled trials were included in the meta-analysis, but the quality of reports of the 14 included studies was poor. Aidi Injection combined with cobalt-60 or navelbine and platinol (NP) showed statistically significant differences in improving the response rate as compared with single use of cobalt-60 (P = 0.000 2) or NP (P = 0.04), and the relative risk (RR) and 95% confidence interval (CI) were 1.93[1.36, 2.72] and 1.18[1.00, 1.38], respectively. However, Aidi Injection combined with etoposide and platinol (EP), taxinol and platinol (TP) or gamma knife showed no significant differences as compared with single use of EP (P = 0.60), TP (P = 0.16) or gamma knife (P = 0.34), respectively. The RR and 95% CI of EP, TP and gamma knife were 1. 17[0.65, 2.09], 1.27[0.91, 1.78] and 1.08 [0.92, 1.26] respectively. Six studies indicated that Aidi Injection combined with NP or gamma knife could improve the quality of life. Six studies showed that Aidi Injection combined with NP or TP could improve the bone marrow hematopoietic function. Three studies indicated that Aidi Injection combined with NP could improve the immune function. Three studies showed that the combined therapy could not improve 1-, 2-, and 3-year survival rates. Conclusion: The results of meta-analysis indicate that Aidi Injection may have adjuvant therapeutic effects in treatment of NSCLC patients, but the sample size is too small and with poor quality, and the existence of publication bias is found. The effects of Aidi Injection need to be confirmed by large multicenter randomized controlled trials.en_HK
dc.languageengen_HK
dc.relation.ispartofJournal of Chinese Integrative Medicineen_HK
dc.subjectAidi Injectionen_HK
dc.subjectNon-Small Cell Lung Canceren_HK
dc.subjectRandomized Controlled Trialsen_HK
dc.subjectSystematic Reviewen_HK
dc.titleAidi Injection as an adjunct therapy for non-small cell lung cancer: A systematic reviewen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3736/jcim20090404en_HK
dc.identifier.scopuseid_2-s2.0-68949213205en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68949213205&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.spage315en_HK
dc.identifier.epage324en_HK

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