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Article: Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
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TitleAdult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
 
AuthorsBao, L5 1 2
Gross, SA1 4
Ryder, J4
Wang, X1 3
Ji, M3
Chen, Y1
Yang, Y1
Zhu, S1
Irons, RD5 1 4
 
KeywordsChemicals And Cas Registry Numbers
 
Issue Date2009
 
PublisherSpringer Japan KK
 
CitationInternational Journal of Hematology, 2009, v. 89 n. 4, p. 431-437 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s12185-009-0283-8
 
AbstractAcute lymphoblastic leukemia (ALL) accounts for 20-30% of adult leukemia in the West. However, detailed studies of B-cell-specific ALL in adult Asian populations are lacking. We diagnosed and characterized 137 consecutive cases of precursor B lymphoblastic leukemia (precursor B-cell ALL) presented to our laboratory in Shanghai using the WHO 2001 classification system. Patient clinical, phenotypic and cytogenetic characteristics were correlated with outcome. In contrast to Western studies, females (71) outnumbered males (66) partly due to an increased prevalence of the CD10- pro B-cell phenotype. Females with a CD10- pro B-cell phenotype exhibited significantly better overall survival than males. The most common cytogenetic abnormality was the Philadelphia chromosome (PH/BCR/ABL) which was found in approximately 37% of the cases. Cases of precursor B cell ALL lacking the PH/BCR/ABL genotype exhibited a pronounced age-dependent, gender prevalence with a modal age in the sixth decade for females compared to the second decade for males. These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance. © 2009 The Japanese Society of Hematology.
 
ISSN0925-5710
2013 Impact Factor: 1.679
2013 SCImago Journal Rankings: 0.815
 
DOIhttp://dx.doi.org/10.1007/s12185-009-0283-8
 
ISI Accession Number IDWOS:000265574500004
Funding AgencyGrant Number
Shanghai Health Study
Benzene Research Health Consortium
Funding Information:

We would like to extend our appreciation to Ann Louden for manuscript and clerical assistance and Anh Le, Qian Chen and Allan Holsomback for database management. We would also like to thank the participating hospitals including Huashan Hospital, Xinhua Hospital, Long March Hospital, Huang Pu Central District Hospital, Renji Hospital, Ruijin Hospital, Huadong Hospital, Jin An Central Hospital, No. 1 People's Hospital, No. 5 People's Hospital, No. 6 People's Hospital, No. 9 People's Hospital, Yang Pu Central Hospital, Zha Bei Central Hospital, Shu Guang Hospital, Chang Ning Central Hospital, Tong Ji Hospital, Shong Jin Central Hospital, Zhong Shan Hospital, Railway Hospital, Rong Hua Hospital, Changhai Hospital, Occupational Disease Hospital, Jiading Central Hospital, 455 Hospital, Shidong Hospital, No. 1 Baoshan Hospital, and Putuo Central Hospital. This work was conducted as part of the Shanghai Health Study and was funded by the Benzene Research Health Consortium consisting of British Petroleum, Amoco, Chevron Texaco, ExxonMobil, Conoco Philips and Shell Chemical Companies.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBao, L
 
dc.contributor.authorGross, SA
 
dc.contributor.authorRyder, J
 
dc.contributor.authorWang, X
 
dc.contributor.authorJi, M
 
dc.contributor.authorChen, Y
 
dc.contributor.authorYang, Y
 
dc.contributor.authorZhu, S
 
dc.contributor.authorIrons, RD
 
dc.date.accessioned2010-09-17T10:40:51Z
 
dc.date.available2010-09-17T10:40:51Z
 
dc.date.issued2009
 
dc.description.abstractAcute lymphoblastic leukemia (ALL) accounts for 20-30% of adult leukemia in the West. However, detailed studies of B-cell-specific ALL in adult Asian populations are lacking. We diagnosed and characterized 137 consecutive cases of precursor B lymphoblastic leukemia (precursor B-cell ALL) presented to our laboratory in Shanghai using the WHO 2001 classification system. Patient clinical, phenotypic and cytogenetic characteristics were correlated with outcome. In contrast to Western studies, females (71) outnumbered males (66) partly due to an increased prevalence of the CD10- pro B-cell phenotype. Females with a CD10- pro B-cell phenotype exhibited significantly better overall survival than males. The most common cytogenetic abnormality was the Philadelphia chromosome (PH/BCR/ABL) which was found in approximately 37% of the cases. Cases of precursor B cell ALL lacking the PH/BCR/ABL genotype exhibited a pronounced age-dependent, gender prevalence with a modal age in the sixth decade for females compared to the second decade for males. These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance. © 2009 The Japanese Society of Hematology.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal of Hematology, 2009, v. 89 n. 4, p. 431-437 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s12185-009-0283-8
 
dc.identifier.citeulike4264150
 
dc.identifier.doihttp://dx.doi.org/10.1007/s12185-009-0283-8
 
dc.identifier.epage437
 
dc.identifier.isiWOS:000265574500004
Funding AgencyGrant Number
Shanghai Health Study
Benzene Research Health Consortium
Funding Information:

We would like to extend our appreciation to Ann Louden for manuscript and clerical assistance and Anh Le, Qian Chen and Allan Holsomback for database management. We would also like to thank the participating hospitals including Huashan Hospital, Xinhua Hospital, Long March Hospital, Huang Pu Central District Hospital, Renji Hospital, Ruijin Hospital, Huadong Hospital, Jin An Central Hospital, No. 1 People's Hospital, No. 5 People's Hospital, No. 6 People's Hospital, No. 9 People's Hospital, Yang Pu Central Hospital, Zha Bei Central Hospital, Shu Guang Hospital, Chang Ning Central Hospital, Tong Ji Hospital, Shong Jin Central Hospital, Zhong Shan Hospital, Railway Hospital, Rong Hua Hospital, Changhai Hospital, Occupational Disease Hospital, Jiading Central Hospital, 455 Hospital, Shidong Hospital, No. 1 Baoshan Hospital, and Putuo Central Hospital. This work was conducted as part of the Shanghai Health Study and was funded by the Benzene Research Health Consortium consisting of British Petroleum, Amoco, Chevron Texaco, ExxonMobil, Conoco Philips and Shell Chemical Companies.

 
dc.identifier.issn0925-5710
2013 Impact Factor: 1.679
2013 SCImago Journal Rankings: 0.815
 
dc.identifier.issue4
 
dc.identifier.scopuseid_2-s2.0-67449136035
 
dc.identifier.spage431
 
dc.identifier.urihttp://hdl.handle.net/10722/92262
 
dc.identifier.volume89
 
dc.languageeng
 
dc.publisherSpringer Japan KK
 
dc.relation.ispartofInternational Journal of Hematology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectChemicals And Cas Registry Numbers
 
dc.titleAdult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
 
dc.typeArticle
 
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Author Affiliations
  1. Fudan University Shanghai Medical College
  2. University of Cincinnati College of Medicine
  3. Huashan Hospital
  4. University of Colorado Health Sciences Center
  5. Cinpathogen, Inc.