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Article: Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases

TitleAdult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherSpringer Japan KK
Citation
International Journal of Hematology, 2009, v. 89 n. 4, p. 431-437 How to Cite?
Abstract
Acute lymphoblastic leukemia (ALL) accounts for 20-30% of adult leukemia in the West. However, detailed studies of B-cell-specific ALL in adult Asian populations are lacking. We diagnosed and characterized 137 consecutive cases of precursor B lymphoblastic leukemia (precursor B-cell ALL) presented to our laboratory in Shanghai using the WHO 2001 classification system. Patient clinical, phenotypic and cytogenetic characteristics were correlated with outcome. In contrast to Western studies, females (71) outnumbered males (66) partly due to an increased prevalence of the CD10- pro B-cell phenotype. Females with a CD10- pro B-cell phenotype exhibited significantly better overall survival than males. The most common cytogenetic abnormality was the Philadelphia chromosome (PH/BCR/ABL) which was found in approximately 37% of the cases. Cases of precursor B cell ALL lacking the PH/BCR/ABL genotype exhibited a pronounced age-dependent, gender prevalence with a modal age in the sixth decade for females compared to the second decade for males. These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance. © 2009 The Japanese Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/92262
ISSN
2013 Impact Factor: 1.679
2013 SCImago Journal Rankings: 0.815
ISI Accession Number ID
Funding AgencyGrant Number
Shanghai Health Study
Benzene Research Health Consortium
Funding Information:

We would like to extend our appreciation to Ann Louden for manuscript and clerical assistance and Anh Le, Qian Chen and Allan Holsomback for database management. We would also like to thank the participating hospitals including Huashan Hospital, Xinhua Hospital, Long March Hospital, Huang Pu Central District Hospital, Renji Hospital, Ruijin Hospital, Huadong Hospital, Jin An Central Hospital, No. 1 People's Hospital, No. 5 People's Hospital, No. 6 People's Hospital, No. 9 People's Hospital, Yang Pu Central Hospital, Zha Bei Central Hospital, Shu Guang Hospital, Chang Ning Central Hospital, Tong Ji Hospital, Shong Jin Central Hospital, Zhong Shan Hospital, Railway Hospital, Rong Hua Hospital, Changhai Hospital, Occupational Disease Hospital, Jiading Central Hospital, 455 Hospital, Shidong Hospital, No. 1 Baoshan Hospital, and Putuo Central Hospital. This work was conducted as part of the Shanghai Health Study and was funded by the Benzene Research Health Consortium consisting of British Petroleum, Amoco, Chevron Texaco, ExxonMobil, Conoco Philips and Shell Chemical Companies.

References

 

Author Affiliations
  1. Fudan University Shanghai Medical College
  2. University of Cincinnati College of Medicine
  3. Huashan Hospital
  4. University of Colorado Health Sciences Center
  5. Cinpathogen, Inc.
DC FieldValueLanguage
dc.contributor.authorBao, Len_HK
dc.contributor.authorGross, SAen_HK
dc.contributor.authorRyder, Jen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorJi, Men_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorZhu, Sen_HK
dc.contributor.authorIrons, RDen_HK
dc.date.accessioned2010-09-17T10:40:51Z-
dc.date.available2010-09-17T10:40:51Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal of Hematology, 2009, v. 89 n. 4, p. 431-437en_HK
dc.identifier.issn0925-5710en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92262-
dc.description.abstractAcute lymphoblastic leukemia (ALL) accounts for 20-30% of adult leukemia in the West. However, detailed studies of B-cell-specific ALL in adult Asian populations are lacking. We diagnosed and characterized 137 consecutive cases of precursor B lymphoblastic leukemia (precursor B-cell ALL) presented to our laboratory in Shanghai using the WHO 2001 classification system. Patient clinical, phenotypic and cytogenetic characteristics were correlated with outcome. In contrast to Western studies, females (71) outnumbered males (66) partly due to an increased prevalence of the CD10- pro B-cell phenotype. Females with a CD10- pro B-cell phenotype exhibited significantly better overall survival than males. The most common cytogenetic abnormality was the Philadelphia chromosome (PH/BCR/ABL) which was found in approximately 37% of the cases. Cases of precursor B cell ALL lacking the PH/BCR/ABL genotype exhibited a pronounced age-dependent, gender prevalence with a modal age in the sixth decade for females compared to the second decade for males. These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance. © 2009 The Japanese Society of Hematology.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan KKen_HK
dc.relation.ispartofInternational Journal of Hematologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleAdult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive casesen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12185-009-0283-8en_HK
dc.identifier.scopuseid_2-s2.0-67449136035en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67449136035&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue4en_HK
dc.identifier.spage431en_HK
dc.identifier.epage437en_HK
dc.identifier.isiWOS:000265574500004-
dc.identifier.citeulike4264150-

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