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Article: Studies on photolysis kinetics of combretastatin A4 phosphate solution

TitleStudies on photolysis kinetics of combretastatin A4 phosphate solution
Authors
KeywordsCombretastatin A4 Phosphate
Inclusion Complex
Photolysis
Issue Date2007
Citation
Chinese Pharmaceutical Journal, 2007, v. 42 n. 7, p. 516-518+519 How to Cite?
AbstractOBJECTIVE: To study photolysis kinetics of combretastatin A4 phosphate solution. METHODS: CA4P solution was exposed to different light. Samples were determined by HPLC. RESULTS: The photolysis kinetics of CA4P solution at different concentration under the same light was different. The photolysis kinetics of CA4P solution at the same concentration under different light was different. Under mercury lamp, photolysis rate was increased with pH increase; under daylight lamp, photolysis rate was decreased with pH increase. The photolysis rate constant of CA4P in water was smaller than that in methanol, respectively (k = 0.002 7 h-1 and k = 0.005 8 h-1). The effect of β-CD,HP-β-CD,Tween 80 on the photolysis rate constant of CA4P was different, the sequence was as follows :kblank (1 × 10-6L·mol-1·h-1) > k HP-β-CD (7 × 10-7L·mol -1·h-1) = kTween 80 (7 × 10 -7L·mol-1·h-1) > k β-CD (6 × 10-7L·mol -1·h-1). CONCLUSION: Light source, concentration, pH and solvent show important influence on photolysis kinetics of CA4P. β-CD, HP-β-CD and Tween 80 to some degree inhibits photolysis process of CA4P.
Persistent Identifierhttp://hdl.handle.net/10722/92258
ISSN
2015 SCImago Journal Rankings: 0.143
References

 

DC FieldValueLanguage
dc.contributor.authorMo, Yen_HK
dc.contributor.authorHe, Y-Jen_HK
dc.contributor.authorYan, G-Qen_HK
dc.contributor.authorLin, L-Yen_HK
dc.contributor.authorChen, Yen_HK
dc.date.accessioned2010-09-17T10:40:44Z-
dc.date.available2010-09-17T10:40:44Z-
dc.date.issued2007en_HK
dc.identifier.citationChinese Pharmaceutical Journal, 2007, v. 42 n. 7, p. 516-518+519en_HK
dc.identifier.issn1001-2494en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92258-
dc.description.abstractOBJECTIVE: To study photolysis kinetics of combretastatin A4 phosphate solution. METHODS: CA4P solution was exposed to different light. Samples were determined by HPLC. RESULTS: The photolysis kinetics of CA4P solution at different concentration under the same light was different. The photolysis kinetics of CA4P solution at the same concentration under different light was different. Under mercury lamp, photolysis rate was increased with pH increase; under daylight lamp, photolysis rate was decreased with pH increase. The photolysis rate constant of CA4P in water was smaller than that in methanol, respectively (k = 0.002 7 h-1 and k = 0.005 8 h-1). The effect of β-CD,HP-β-CD,Tween 80 on the photolysis rate constant of CA4P was different, the sequence was as follows :kblank (1 × 10-6L·mol-1·h-1) > k HP-β-CD (7 × 10-7L·mol -1·h-1) = kTween 80 (7 × 10 -7L·mol-1·h-1) > k β-CD (6 × 10-7L·mol -1·h-1). CONCLUSION: Light source, concentration, pH and solvent show important influence on photolysis kinetics of CA4P. β-CD, HP-β-CD and Tween 80 to some degree inhibits photolysis process of CA4P.en_HK
dc.languageengen_HK
dc.relation.ispartofChinese Pharmaceutical Journalen_HK
dc.subjectCombretastatin A4 Phosphateen_HK
dc.subjectInclusion Complexen_HK
dc.subjectPhotolysisen_HK
dc.titleStudies on photolysis kinetics of combretastatin A4 phosphate solutionen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-54549086721en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54549086721&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue7en_HK
dc.identifier.spage516en_HK
dc.identifier.epage518+519en_HK

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