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Article: The nuclear localization of NFκB and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinoma

TitleThe nuclear localization of NFκB and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinoma
Authors
KeywordsCarcinoma
HPV16 E7
Laryngeal squamous cell
NFκB
p53
Issue Date2003
PublisherHistochemical Society. The Journal's web site is located at http://intl.jhc.org
Citation
Journal Of Histochemistry And Cytochemistry, 2003, v. 51 n. 4, p. 533-539 How to Cite?
AbstractThe interaction between the HPV (human papilloma virus) 16 E7 and other cell growth factors, such as p53 and NFκB in laryngeal cancer is not clearly understood. The aim of this study was to examine the expression of these three proteins in tumor and nontumor laryngeal tissues from patients with laryngeal squamous cell carcinoma. These three proteins were dominantly expressed in the nucleus and their levels were higher in the tumor tissue than in the non-tumor tissue, although the comparison between the tumor and non-tumor tissues of p53 staining did not reach significance. The intensity of the nuclear stain of E7 and p53 was stronger than that of p65, a subunit of NFκB. Correlation analysis revealed that there was a positive relationship between the level of HPV16 E7 and the expression of p65. The correlation between E7 and p53 was also significant, although to a lesser degree. The finding of nuclear localization of p65 suggests that NFκB is constantly activated in the laryngeal cancer cells, whereas the sequestration of p53 in the nucleus may represent a mutated form of p53, which is probably inactivated by HPV16 oncoproteins. In conclusion, this study suggests that the nuclear localization of NFκB and p53 may play a role in the development of human laryngeal squamous cell carcinoma infected with HPV16.
Persistent Identifierhttp://hdl.handle.net/10722/92247
ISSN
2015 Impact Factor: 1.953
2015 SCImago Journal Rankings: 1.187
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDu, Jen_HK
dc.contributor.authorChen, GGen_HK
dc.contributor.authorVlantis, ACen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorVan Hasselt, ACen_HK
dc.date.accessioned2010-09-17T10:40:25Z-
dc.date.available2010-09-17T10:40:25Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Histochemistry And Cytochemistry, 2003, v. 51 n. 4, p. 533-539en_HK
dc.identifier.issn0022-1554en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92247-
dc.description.abstractThe interaction between the HPV (human papilloma virus) 16 E7 and other cell growth factors, such as p53 and NFκB in laryngeal cancer is not clearly understood. The aim of this study was to examine the expression of these three proteins in tumor and nontumor laryngeal tissues from patients with laryngeal squamous cell carcinoma. These three proteins were dominantly expressed in the nucleus and their levels were higher in the tumor tissue than in the non-tumor tissue, although the comparison between the tumor and non-tumor tissues of p53 staining did not reach significance. The intensity of the nuclear stain of E7 and p53 was stronger than that of p65, a subunit of NFκB. Correlation analysis revealed that there was a positive relationship between the level of HPV16 E7 and the expression of p65. The correlation between E7 and p53 was also significant, although to a lesser degree. The finding of nuclear localization of p65 suggests that NFκB is constantly activated in the laryngeal cancer cells, whereas the sequestration of p53 in the nucleus may represent a mutated form of p53, which is probably inactivated by HPV16 oncoproteins. In conclusion, this study suggests that the nuclear localization of NFκB and p53 may play a role in the development of human laryngeal squamous cell carcinoma infected with HPV16.en_HK
dc.languageengen_HK
dc.publisherHistochemical Society. The Journal's web site is located at http://intl.jhc.orgen_HK
dc.relation.ispartofJournal of Histochemistry and Cytochemistryen_HK
dc.subjectCarcinomaen_HK
dc.subjectHPV16 E7en_HK
dc.subjectLaryngeal squamous cellen_HK
dc.subjectNFκBen_HK
dc.subjectp53en_HK
dc.titleThe nuclear localization of NFκB and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12642632-
dc.identifier.scopuseid_2-s2.0-0037388183en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037388183&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue4en_HK
dc.identifier.spage533en_HK
dc.identifier.epage539en_HK
dc.identifier.isiWOS:000182001600015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDu, J=36837684600en_HK
dc.identifier.scopusauthoridChen, GG=35291566400en_HK
dc.identifier.scopusauthoridVlantis, AC=35585515400en_HK
dc.identifier.scopusauthoridXu, H=36160491400en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridVan Hasselt, AC=6603932076en_HK

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