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Article: Nasopharyngectomy and surgical margin status: A survival analysis

TitleNasopharyngectomy and surgical margin status: A survival analysis
Authors
KeywordsReferences (26) View In Table Layout
Issue Date2007
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.com
Citation
Archives Of Otolaryngology - Head And Neck Surgery, 2007, v. 133 n. 12, p. 1296-1301 How to Cite?
AbstractObjective: To explore whether the margin status at surgical salvage nasopharyngectomy for local residual or recurrent nasopharyngeal carcinoma affects patient survival. Design: Retrospective case series review. Setting: Academic tertiary referral center. Patients: Seventy-nine consecutive patients with operable local residual or recurrent nasopharyngeal carcinoma after failure of primary treatment with radiotherapy with or without chemotherapy underwent surgical salvage nasopharyngectomy with curative intent between November 28, 1987, and November 17, 2003. Sixty-one patients were men and 18 were women. Their mean age was 48 years (age range, 26-70 years). Intervention: Surgical salvage nasopharyngectomy. Main Outcome Measures: The status of the closest margin at surgery was assessed as clear, close, or positive. Survival time was measured from the date of surgery to the date of the last follow-up, to the date of an event occurrence, or to the date of death. The Kaplan-Meier method was used to estimate the probability of local progression-free survival and overall survival at 5 years. Differences in survival rates between surgical margin statuses were assessed using the log-rank test. Results: Five-year overall survival for patients with clear margins was 77%, for patients with close margins was 46% (P = .05), and for patients with positive margins was 23% (P < .001). Conclusion: Clear surgical margins at the time of surgical salvage nasopharyngectomy for residual or recurrent nasopharyngeal carcinoma positively affect patient survival. ©2007 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/92245
ISSN
2014 Impact Factor: 2.327
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVlantis, ACen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorYu, BKHen_HK
dc.contributor.authorKam, MKMen_HK
dc.contributor.authorTong, MCFen_HK
dc.contributor.authorLo, PSYen_HK
dc.contributor.authorVan Hasselt, CAen_HK
dc.date.accessioned2010-09-17T10:40:21Z-
dc.date.available2010-09-17T10:40:21Z-
dc.date.issued2007en_HK
dc.identifier.citationArchives Of Otolaryngology - Head And Neck Surgery, 2007, v. 133 n. 12, p. 1296-1301en_HK
dc.identifier.issn0886-4470en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92245-
dc.description.abstractObjective: To explore whether the margin status at surgical salvage nasopharyngectomy for local residual or recurrent nasopharyngeal carcinoma affects patient survival. Design: Retrospective case series review. Setting: Academic tertiary referral center. Patients: Seventy-nine consecutive patients with operable local residual or recurrent nasopharyngeal carcinoma after failure of primary treatment with radiotherapy with or without chemotherapy underwent surgical salvage nasopharyngectomy with curative intent between November 28, 1987, and November 17, 2003. Sixty-one patients were men and 18 were women. Their mean age was 48 years (age range, 26-70 years). Intervention: Surgical salvage nasopharyngectomy. Main Outcome Measures: The status of the closest margin at surgery was assessed as clear, close, or positive. Survival time was measured from the date of surgery to the date of the last follow-up, to the date of an event occurrence, or to the date of death. The Kaplan-Meier method was used to estimate the probability of local progression-free survival and overall survival at 5 years. Differences in survival rates between surgical margin statuses were assessed using the log-rank test. Results: Five-year overall survival for patients with clear margins was 77%, for patients with close margins was 46% (P = .05), and for patients with positive margins was 23% (P < .001). Conclusion: Clear surgical margins at the time of surgical salvage nasopharyngectomy for residual or recurrent nasopharyngeal carcinoma positively affect patient survival. ©2007 American Medical Association. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.comen_HK
dc.relation.ispartofArchives of Otolaryngology - Head and Neck Surgeryen_HK
dc.subjectReferences (26) View In Table Layouten_HK
dc.titleNasopharyngectomy and surgical margin status: A survival analysisen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1001/archotol.133.12.1296en_HK
dc.identifier.pmid18086975-
dc.identifier.scopuseid_2-s2.0-37349009755en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37349009755&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1296en_HK
dc.identifier.epage1301en_HK
dc.identifier.isiWOS:000251684900018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridVlantis, AC=35585515400en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridYu, BKH=14621860200en_HK
dc.identifier.scopusauthoridKam, MKM=35332321400en_HK
dc.identifier.scopusauthoridTong, MCF=13310275400en_HK
dc.identifier.scopusauthoridLo, PSY=15044923800en_HK
dc.identifier.scopusauthoridVan Hasselt, CA=7103394173en_HK

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